Found 45 Enz. Inhib. hit(s) for PDB: 4MKC TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of ALK (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of EML4-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) T1151 insertion mutant expressed in baculovirus ...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of purified ALK (unknown origin) after 60 mins by ELISA kinase assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1269A mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) S1206Y mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Korea Research Institute Of Chemical Technology
US Patent
Korea Research Institute Of Chemical Technology
US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: <5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type ALK (unknown origin) using TK as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild-type ALK (unknown origin) using peptide as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type ALK (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of wild type ALK (unknown origin) by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) L1196M mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of TEL-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of ALK (unknown origin) transfected in mouse BA/F3 cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1202R mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system after 1 hr by mob...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human N-terminal GST-tagged ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system aft...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of human N-terminal GST-tagged ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system aft...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
University Of Michigan Comprehensive Cancer Center
Curated by ChEMBL
Affinity DataKd: 1.30nMAssay Description:Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
