Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
gamma-Aminobutyric Acid Type B Receptor (411/425 = 97%)† (Rattus norvegicus (rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 220 | -37.6 | n/a | n/a | 750 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (412/412 = 100%)† (Homo sapiens (Human)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Displacement of [3H]CGP54626 from GABA-B receptor (unknown origin) by radioligand binding assay | J Med Chem 58: 6336-47 (2015) Article DOI: 10.1021/jm5018913 BindingDB Entry DOI: 10.7270/Q2T155F6 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (412/412 = 100%)† (Homo sapiens (Human)) | BDBM50032964![]() ((R)-4-Amino-3-(4-chloro-phenyl)-butyric acid | 4-A...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy AG Curated by ChEMBL | Assay Description Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum | J Med Chem 38: 3297-312 (1995) Article DOI: 10.1021/jm00017a015 BindingDB Entry DOI: 10.7270/Q2N58KDP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro displacement of [3H]-GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes | Bioorg Med Chem Lett 3: 515-518 (1993) Article DOI: 10.1016/S0960-894X(01)81218-X BindingDB Entry DOI: 10.7270/Q2BR8S4N | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM50032964![]() ((R)-4-Amino-3-(4-chloro-phenyl)-butyric acid | 4-A...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy AG Curated by ChEMBL | Assay Description Inhibition of [3H]-CGP-27,492 binding to Gamma-aminobutyric acid type B receptor of rat cortex | J Med Chem 38: 3297-312 (1995) Article DOI: 10.1021/jm00017a015 BindingDB Entry DOI: 10.7270/Q2N58KDP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (412/412 = 100%)† (Homo sapiens (Human)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy AG Curated by ChEMBL | Assay Description Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum | J Med Chem 38: 3297-312 (1995) Article DOI: 10.1021/jm00017a015 BindingDB Entry DOI: 10.7270/Q2N58KDP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]-baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranes | J Med Chem 28: 1440-6 (1985) Article DOI: 10.1021/jm00148a012 BindingDB Entry DOI: 10.7270/Q2TD9WC9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy AG Curated by ChEMBL | Assay Description Inhibition of [3H]-CGP-27,492 binding to Gamma-aminobutyric acid type B receptor of rat cortex | J Med Chem 38: 3297-312 (1995) Article DOI: 10.1021/jm00017a015 BindingDB Entry DOI: 10.7270/Q2N58KDP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM50032964![]() ((R)-4-Amino-3-(4-chloro-phenyl)-butyric acid | 4-A...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Displacement of [3H]-GABA from Gamma-aminobutyric acid type B receptor | J Med Chem 42: 2053-9 (1999) Article DOI: 10.1021/jm990076+ BindingDB Entry DOI: 10.7270/Q2WW7GV9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacie Chimique, Facult� de Pharmacie, Lille, France. Curated by ChEMBL | Assay Description Inhibition of [3H]baclofen binding to rat gamma-aminobutyric acid type B receptor. | J Med Chem 34: 2557-60 (1991) Article DOI: 10.1021/jm00112a033 BindingDB Entry DOI: 10.7270/Q2GQ6ZC0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor of rat brain membranes | J Med Chem 30: 743-6 (1987) Article DOI: 10.1021/jm00387a031 BindingDB Entry DOI: 10.7270/Q22V2GPC | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against Gamma-aminobutyric acid type B receptor in rat brain synaptosomes after 30 minutes | Bioorg Med Chem Lett 6: 1709-1714 (1996) Article DOI: 10.1016/0960-894X(96)00307-1 BindingDB Entry DOI: 10.7270/Q22J6CCH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacie Chimique, Facult� de Pharmacie, Lille, France. Curated by ChEMBL | Assay Description Inhibition of [3H]baclofen binding to rat gamma-aminobutyric acid type B receptor. | J Med Chem 34: 2557-60 (1991) Article DOI: 10.1021/jm00112a033 BindingDB Entry DOI: 10.7270/Q2GQ6ZC0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (411/425 = 97%)† (Rattus norvegicus (Rat)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Neurochimie du CNRS Curated by ChEMBL | Assay Description Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor | J Med Chem 34: 1307-13 (1991) Article DOI: 10.1021/jm00108a011 BindingDB Entry DOI: 10.7270/Q27D2VRW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (412/412 = 100%)† (Homo sapiens (Human)) | BDBM50032964![]() ((R)-4-Amino-3-(4-chloro-phenyl)-butyric acid | 4-A...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hr... | J Med Chem 56: 2456-65 (2013) Article DOI: 10.1021/jm301805e BindingDB Entry DOI: 10.7270/Q25T3MTS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
GABA-B receptor 1/2 (412/412 = 100%)† (Homo sapiens (Human)) | BDBM24182![]() (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hr... | J Med Chem 56: 2456-65 (2013) Article DOI: 10.1021/jm301805e BindingDB Entry DOI: 10.7270/Q25T3MTS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |