Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) for PDB: 4N1T
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152125(CHEMBL3781316)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair