Affinity Data by PDB ID

Search and Browse
- Target
- Compound
- Special tools
- Citation
- Special Data Sets
  - Host Guest Systems
  - Prot-Lig Validation Sets
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Enter Data

PDB code 4NF5

Identical Ligands in BindingDB

Found 6 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1 (138/139 > 99%)^† (Rattus norvegicus (Rat)-RAT)	BDBM50004897 ((APV)2-Amino-5-phosphono-pentanoic acid \| (R)-2-Am...) Show SMILES NC(CCCP(O)(O)=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D (151/151 = 100%)^† (RAT)	BDBM81977 (CAS_79055-68-8 \| CB3371309 \| D-AP5 \| D-APV) Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by PDSP K_i Database									Br J Pharmacol 95: 932-8 (1988) Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF
CIBA-GEIGY Corporation Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D (151/151 = 100%)^† (RAT)	BDBM81977 (CAS_79055-68-8 \| CB3371309 \| D-AP5 \| D-APV) Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by PDSP K_i Database									Br J Pharmacol 95: 932-8 (1988) Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF
CIBA-GEIGY Corporation Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1 (151/151 = 100%)^† (Rattus norvegicus (Rat)-RAT)	BDBM50004897 ((APV)2-Amino-5-phosphono-pentanoic acid \| (R)-2-Am...) Show SMILES NC(CCCP(O)(O)=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2B expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1 (151/151 = 100%)^† (RAT-Rattus norvegicus (Rat))	BDBM50004897 ((APV)2-Amino-5-phosphono-pentanoic acid \| (R)-2-Am...) Show SMILES NC(CCCP(O)(O)=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...				J Med Chem 48: 2627-37 (2005) Article DOI: 10.1021/jm0492498 BindingDB Entry DOI: 10.7270/Q2FJ2G89
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D (151/151 = 100%)^† (RAT)	BDBM81977 (CAS_79055-68-8 \| CB3371309 \| D-AP5 \| D-APV) Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by PDSP K_i Database									Biochemistry 24: 2401-5 (1985) Article DOI: 10.1021/bi00331a002 BindingDB Entry DOI: 10.7270/Q2W094FK
University of Minnesota Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)

Reorder this table by ec50
Reorder this table by ic50
Reorder this table by Kd
Reorder this table by pH
Reorder this table by T
Reorder this table by ΔH°
Reorder this table by -TΔS°
Change energy units to: kcal/mole

Search BindingMOAD for More Affinity Data:

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output