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PDB code 4NF5

Compile Data Set for Download or QSAR

Identical Ligands in BindingDB

Found 6 hits Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate [NMDA] receptor subunit epsilon 1/zeta 1

  (138/139 > 99%)
(Rattus norvegicus (Rat)-RAT)
BDBM50004897
PNG
((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...)
Show SMILES NC(CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
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280n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2A expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D

  (151/151 = 100%)
(RAT)
BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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350n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




Br J Pharmacol 95: 932-8 (1988)


Article DOI: 10.1111/j.1476-5381.1988.tb11723.x
BindingDB Entry DOI: 10.7270/Q2Z036NF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D

  (151/151 = 100%)
(RAT)
BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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400n/an/an/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by PDSP Ki Database




Br J Pharmacol 95: 932-8 (1988)


Article DOI: 10.1111/j.1476-5381.1988.tb11723.x
BindingDB Entry DOI: 10.7270/Q2Z036NF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 2/zeta 1

  (151/151 = 100%)
(Rattus norvegicus (Rat)-RAT)
BDBM50004897
PNG
((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...)
Show SMILES NC(CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
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460n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2B expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate [NMDA] receptor subunit epsilon 3/zeta 1

  (151/151 = 100%)
(RAT-Rattus norvegicus (Rat))
BDBM50004897
PNG
((APV)2-Amino-5-phosphono-pentanoic acid | (R)-2-Am...)
Show SMILES NC(CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
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Article
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1.64E+3n/an/an/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibitory constant against (S)-glutamate and glycine evoked currents mediated by N-methyl-D-aspartate glutamate receptor NR1a/NR2C expressed in Xeno...


J Med Chem 48: 2627-37 (2005)


Article DOI: 10.1021/jm0492498
BindingDB Entry DOI: 10.7270/Q2FJ2G89
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor NMDA 1/2D

  (151/151 = 100%)
(RAT)
BDBM81977
PNG
(CAS_79055-68-8 | CB3371309 | D-AP5 | D-APV)
Show SMILES N[C@H](CCCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by PDSP Ki Database




Biochemistry 24: 2401-5 (1985)


Article DOI: 10.1021/bi00331a002
BindingDB Entry DOI: 10.7270/Q2W094FK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)

Search BindingMOAD for More Affinity Data:

* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
Identities from BLAST output