Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)† (Toxoplasma gondii) | BDBM50446179![]() (CHEMBL3109011 | US9518026, Example 39 | US9956214,...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrate | ACS Med Chem Lett 5: 40-44 (2014) Article DOI: 10.1021/ml400315s BindingDB Entry DOI: 10.7270/Q28917BZ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)† (Toxoplasma gondii) | BDBM50446179![]() (CHEMBL3109011 | US9518026, Example 39 | US9956214,...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l... | Bioorg Med Chem Lett 26: 5487-5491 (2016) Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)† (Toxoplasma gondii) | BDBM50446179![]() (CHEMBL3109011 | US9518026, Example 39 | US9956214,...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization US Patent | Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... | US Patent US9956214 (2018) BindingDB Entry DOI: 10.7270/Q23J3G91 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)† (Toxoplasma gondii) | BDBM50446179![]() (CHEMBL3109011 | US9518026, Example 39 | US9956214,...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization US Patent | Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... | US Patent US9956214 (2018) BindingDB Entry DOI: 10.7270/Q23J3G91 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)† (Toxoplasma gondii) | BDBM50446179![]() (CHEMBL3109011 | US9518026, Example 39 | US9956214,...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization US Patent | Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... | US Patent US9518026 (2016) BindingDB Entry DOI: 10.7270/Q2BV7JN4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |