Affinity Data by PDB ID

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PDB code 4ONA

Identical Ligands in BindingDB

Found 5 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)^† (Toxoplasma gondii)	BDBM50446179 (CHEMBL3109011 \| US9518026, Example 39 \| US9956214,...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrate				ACS Med Chem Lett 5: 40-44 (2014) Article DOI: 10.1021/ml400315s BindingDB Entry DOI: 10.7270/Q28917BZ
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)^† (Toxoplasma gondii)	BDBM50446179 (CHEMBL3109011 \| US9518026, Example 39 \| US9956214,...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l...				Bioorg Med Chem Lett 26: 5487-5491 (2016) Article DOI: 10.1016/j.bmcl.2016.10.014 BindingDB Entry DOI: 10.7270/Q2J968BR
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)^† (Toxoplasma gondii)	BDBM50446179 (CHEMBL3109011 \| US9518026, Example 39 \| US9956214,...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US9956214 (2018) BindingDB Entry DOI: 10.7270/Q23J3G91
					More data for this Ligand-Target Pair				3D Structure (crystal)
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)^† (Toxoplasma gondii)	BDBM50446179 (CHEMBL3109011 \| US9518026, Example 39 \| US9956214,...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US9956214 (2018) BindingDB Entry DOI: 10.7270/Q23J3G91
					More data for this Ligand-Target Pair				3D Structure (crystal)
Calmodulin-domain protein kinase 1 (CDPK1) (481/484 > 99%)^† (Toxoplasma gondii)	BDBM50446179 (CHEMBL3109011 \| US9518026, Example 39 \| US9956214,...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Through its Center for Commercialization US Patent					Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...				US Patent US9518026 (2016) BindingDB Entry DOI: 10.7270/Q2BV7JN4
					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output