Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (397/397 = 100%)† (Homo sapiens (Human)) | BDBM50015538![]() (CHEMBL3265330) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc Curated by ChEMBL | Assay Description Inhibition of BACE1 (unknown origin) assessed as amyloid beta production wild type APP expressing by cell based assay | Bioorg Med Chem Lett 24: 2477-80 (2014) Article DOI: 10.1016/j.bmcl.2014.04.012 BindingDB Entry DOI: 10.7270/Q22J6DDC | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Beta-secretase 1 (397/397 = 100%)† (Homo sapiens (Human)) | BDBM50015538![]() (CHEMBL3265330) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc Curated by ChEMBL | Assay Description Inhibition of BACE1 (unknown origin) | Bioorg Med Chem Lett 24: 2477-80 (2014) Article DOI: 10.1016/j.bmcl.2014.04.012 BindingDB Entry DOI: 10.7270/Q22J6DDC | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |