Affinity Data by PDB ID

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PDB code 4QOC

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
MDM2 and p53 (95/95 = 100%)^† (Homo sapiens (Human))	BDBM50448945 (CHEMBL3125521 \| US9296736, 381 \| US9593129, Exampl...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	25
Amgen Inc US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
Amgen Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) (95/95 = 100%)^† (Homo sapiens (Human))	BDBM50448945 (CHEMBL3125521 \| US9296736, 381 \| US9593129, Exampl...) Show SMILES Show InChI	PDB GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9593129 (2017) BindingDB Entry DOI: 10.7270/Q20P1232
Amgen Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (95/95 = 100%)^† (Homo sapiens (Human))	BDBM50448945 (CHEMBL3125521 \| US9296736, 381 \| US9593129, Exampl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay				J Med Chem 57: 1454-72 (2014) Article DOI: 10.1021/jm401753e BindingDB Entry DOI: 10.7270/Q24M960Z
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output