Affinity Data by PDB ID

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PDB code 4RVR

Identical Ligands in BindingDB

Found 5 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain adjacent to zinc finger domain protein 2B (115/115 = 100%)^† (Homo sapiens (Human))	BDBM50148270 (CHEMBL3739699) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
University of Z£rich Curated by ChEMBL					Assay Description Competitive binding affinity to His-tagged BRAZ2B (unknown origin) expressed in Escherichia coli BL21(DE3) cells by AlphaScreen assay in presence of ...				J Med Chem 59: 3087-97 (2016) Article DOI: 10.1021/acs.jmedchem.5b01757 BindingDB Entry DOI: 10.7270/Q2MP556R
University of Z£rich Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B (115/115 = 100%)^† (Homo sapiens (Human))	BDBM50148270 (CHEMBL3739699) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...				J Med Chem 59: 1410-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b00209 BindingDB Entry DOI: 10.7270/Q2PK0J09
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B (115/115 = 100%)^† (Homo sapiens (Human))	BDBM50148270 (CHEMBL3739699) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to BAZ2B in human HUT78 cell extract by chemoproteomic competition binding assay				J Med Chem 59: 1410-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b00209 BindingDB Entry DOI: 10.7270/Q2PK0J09
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B (115/115 = 100%)^† (Homo sapiens (Human))	BDBM50148270 (CHEMBL3739699) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli by isothermal titration calorimetric analysis				J Med Chem 59: 1410-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b00209 BindingDB Entry DOI: 10.7270/Q2PK0J09
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain adjacent to zinc finger domain protein 2B (115/115 = 100%)^† (Homo sapiens (Human))	BDBM50148270 (CHEMBL3739699) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to biotinylated C-terminal Avi/His-TEV-tagged BAZ2B (unknown origin) expressed in Escherichia coli by Biolayer Interferometric analy...				J Med Chem 59: 1410-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b00209 BindingDB Entry DOI: 10.7270/Q2PK0J09
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output