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Report error Found 6 Enz. Inhib. hit(s) for PDB: 4TWN
TargetEphrin type-A receptor 3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: <1.00E+3nMAssay Description:Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEphrin type-A receptor 3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of EPHA3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEphrin type-A receptor 3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  880nMAssay Description:Binding constant for EPHA3 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEphrin type-A receptor 3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  580nMAssay Description:Average Binding Constant for EPHA3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEphrin type-A receptor 3 [1-975](Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  880nMpH: 7.4 T: 25°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssayPDB3D3D Structure (crystal)

TargetEphrin type-A receptor 3(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  880nMAssay Description:Binding constant for EPHA3 kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)