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Report error Found 10 Enz. Inhib. hit(s) for PDB: 4UH1
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nM ΔG°:  -46.1kJ/molepH: 7.4 T: 37°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli by oxyhemoglobin NO assayMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  17nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  59nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  59nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  59nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Human)
Northwestern University

US Patent
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  59nMAssay Description:Inhibition of human recombinant nNOS expressed in Escherichia coli by oxyhemoglobin NO assayMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  117nM ΔG°:  -41.2kJ/molepH: 7.4 T: 37°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  139nM ΔG°:  -40.7kJ/molepH: 7.4 T: 37°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)