Compile Data Set for Download or QSAR
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Found 2 Enz. Inhib. hit(s) for PDB: 4WT2
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM144638(US8952036, Ex. 3)
Affinity DataIC50:  0.600nMAssay Description:Binding affinity to human GST-thrombin-tagged MDM2 ( 1 to 188 aa) assessed as inhibition of interaction with human p53 preincubated with compound for...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM144638(US8952036, Ex. 3)
Affinity DataKd:  0.257nMAssay Description:Binding affinity to human MDM2 by by isothermal titration calorimetryMore data for this Ligand-Target Pair