Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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DNA (cytosine-5)-methyltransferase 1 (DNMT1) (1250/1250 = 100%)† (Homo sapiens (Human)) | BDBM50009672![]() (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DNMT1 | Bioorg Med Chem Lett 19: 2742-6 (2009) Article DOI: 10.1016/j.bmcl.2009.03.132 BindingDB Entry DOI: 10.7270/Q2C53KV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (1250/1250 = 100%)† (Homo sapiens (Human)) | BDBM50009672![]() (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London Curated by ChEMBL | Assay Description Inhibition of full length N-terminal His6-tagged human DNMT1 after 1 hr by fluorescence analysis | J Med Chem 55: 1731-50 (2012) Article DOI: 10.1021/jm2016182 BindingDB Entry DOI: 10.7270/Q22F7PHC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (1250/1250 = 100%)† (Homo sapiens (Human)) | BDBM50009672![]() (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 941 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southampton Curated by ChEMBL | Assay Description Inhibition of human Dnmt1 using oligonucleotide 2 as substrate after 5000 sec by micro plate reader based real-time break-light assay | Bioorg Med Chem Lett 22: 3079-82 (2012) Article DOI: 10.1016/j.bmcl.2012.03.072 BindingDB Entry DOI: 10.7270/Q25Q4X4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (1250/1250 = 100%)† (Homo sapiens (Human)) | BDBM50009672![]() (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells | Bioorg Med Chem Lett 19: 2747-51 (2009) Article DOI: 10.1016/j.bmcl.2009.03.113 BindingDB Entry DOI: 10.7270/Q2W37WC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (1250/1250 = 100%)† (Homo sapiens (Human)) | BDBM50009672![]() (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Salerno Curated by ChEMBL | Assay Description Inhibition of human recombinant DNMT1 expressed in Sf9 cells assessed as incorporation of [3H]S-adenosyl methionine into hemimethylated oligonucleoti... | J Med Chem 54: 7663-77 (2011) Article DOI: 10.1021/jm2010404 BindingDB Entry DOI: 10.7270/Q28S4Q98 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (1250/1250 = 100%)† (Homo sapiens (Human)) | BDBM50009672![]() (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Deutsches Krebsforschungszentrum Curated by ChEMBL | Assay Description Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting | Bioorg Med Chem 18: 822-9 (2010) Article DOI: 10.1016/j.bmc.2009.11.050 BindingDB Entry DOI: 10.7270/Q2CF9Q69 | |||||||||||
More data for this Ligand-Target Pair |