Affinity Data by PDB ID

PDB code 4ZAU

Identical Ligands in BindingDB

Found 72 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of EGFR T790M/deletion (746 to 750 residues) mutant (unknown origin)				Bioorg Med Chem Lett 26: 534-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.078 BindingDB Entry DOI: 10.7270/Q2HH6MZQ
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of EGFR T790M/L858R mutant (unknown origin)				Bioorg Med Chem Lett 26: 534-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.078 BindingDB Entry DOI: 10.7270/Q2HH6MZQ
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin)				Bioorg Med Chem Lett 26: 534-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.078 BindingDB Entry DOI: 10.7270/Q2HH6MZQ
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Reversible inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus...				J Med Chem 60: 2361-2372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01626 BindingDB Entry DOI: 10.7270/Q2FB556R
TU Dortmund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls University T£bingen Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin incubated ...				J Med Chem 60: 5613-5637 (2017) Article DOI: 10.1021/acs.jmedchem.7b00316 BindingDB Entry DOI: 10.7270/Q2V98BCK
Eberhard Karls University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR (unknown origin)				J Med Chem 60: 4636-4656 (2017) BindingDB Entry DOI: 10.7270/Q26T0Q47
Eberhard Karls Universit£t T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assay				Eur J Med Chem 148: 221-237 (2018) BindingDB Entry DOI: 10.7270/Q2H70JF4
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co. Itd. Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...				Bioorg Med Chem Lett 28: 1257-1261 (2018) BindingDB Entry DOI: 10.7270/Q2GB26Q2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...				J Med Chem 60: 7725-7744 (2017) BindingDB Entry DOI: 10.7270/Q28W3GS9
TU Dortmund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
MER intracellular domain/EGFR extracellular domain chimera (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system preincubated for 30 mins followe...				J Med Chem 60: 7725-7744 (2017) BindingDB Entry DOI: 10.7270/Q28W3GS9
TU Dortmund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R mutant (unknown origin)				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M double mutant (unknown origin)				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR L858R mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assay				Eur J Med Chem 148: 221-237 (2018) BindingDB Entry DOI: 10.7270/Q2H70JF4
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay				Bioorg Med Chem 26: 2173-2185 (2018) BindingDB Entry DOI: 10.7270/Q2H41V28
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression...				J Med Chem 60: 2361-2372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01626 BindingDB Entry DOI: 10.7270/Q2FB556R
TU Dortmund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard Karls University T£bingen Curated by ChEMBL					Assay Description Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubat...				J Med Chem 60: 5613-5637 (2017) Article DOI: 10.1021/acs.jmedchem.7b00316 BindingDB Entry DOI: 10.7270/Q2V98BCK
Eberhard Karls University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M double mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay				Bioorg Med Chem 26: 2173-2185 (2018) BindingDB Entry DOI: 10.7270/Q2H41V28
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expressi...				Bioorg Med Chem 26: 1810-1822 (2018) BindingDB Entry DOI: 10.7270/Q2FF3W1G
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
MER intracellular domain/EGFR extracellular domain chimera (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...				J Med Chem 60: 7725-7744 (2017) BindingDB Entry DOI: 10.7270/Q28W3GS9
TU Dortmund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor(L858R, T790M) (325/327 > 99%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. US Patent					Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...				US Patent US9890168 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NPJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expressi...				Bioorg Med Chem 26: 1810-1822 (2018) BindingDB Entry DOI: 10.7270/Q2FF3W1G
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin)				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (EGFR)(T790M/L858R) (325/327 > 99%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. US Patent					Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...				US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR L858R/T790M double mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence a...				Eur J Med Chem 148: 221-237 (2018) BindingDB Entry DOI: 10.7270/Q2H70JF4
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M double mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co. Itd. Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...				Bioorg Med Chem Lett 28: 1257-1261 (2018) BindingDB Entry DOI: 10.7270/Q2GB26Q2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. US Patent					Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine...				US Patent US9890168 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NPJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	25
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. US Patent					Assay Description All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...				US Patent US10085983 (2018) BindingDB Entry DOI: 10.7270/Q28W3GBG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system usi...				Bioorg Med Chem 26: 1810-1822 (2018) BindingDB Entry DOI: 10.7270/Q2FF3W1G
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA				ACS Med Chem Lett 9: 1123-1127 (2018) BindingDB Entry DOI: 10.7270/Q2FR00BQ
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
MER intracellular domain/EGFR extracellular domain chimera (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University-Peking University Joint Center for Life Sciences Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M mutant (unknown origin) using Tyr 4 peptide as substrate in presence of ATP by Z-LYTE kinase assay				Bioorg Med Chem 25: 4553-4559 (2017) BindingDB Entry DOI: 10.7270/Q28K7CKS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
St. John's University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M mutant (unknown origin)				Bioorg Med Chem Lett 27: 4832-4837 (2017) BindingDB Entry DOI: 10.7270/Q22Z183X
St. John's University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA				Bioorg Med Chem 24: 2673-80 (2016) Article DOI: 10.1016/j.bmc.2016.04.032 BindingDB Entry DOI: 10.7270/Q26W9D0T
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as sub...				Eur J Med Chem 152: 298-306 (2018) BindingDB Entry DOI: 10.7270/Q2PC34ZZ
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR deletion/T790M mutant autophosphorylation in human PC9-DRH cells after 2 hrs by sandwich ELISA				J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
St. John's University Curated by ChEMBL					Assay Description Inhibition of EGFR exon 19 deletion mutant (unknown origin)				Bioorg Med Chem Lett 27: 4832-4837 (2017) BindingDB Entry DOI: 10.7270/Q22Z183X
St. John's University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Normal University Curated by ChEMBL					Assay Description Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated fo...				Eur J Med Chem 135: 12-23 (2017) BindingDB Entry DOI: 10.7270/Q28P630H
Nanjing Normal University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs by ELISA				Bioorg Med Chem Lett 26: 1861-8 (2016) Article DOI: 10.1016/j.bmcl.2016.02.067 BindingDB Entry DOI: 10.7270/Q2C24Z9V
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 2 hrs by sandwich ELISA				J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR Del ex19 mutant phosphorylation in human PC9 cells preincubated for 2 hrs by ELISA				Bioorg Med Chem Lett 26: 1861-8 (2016) Article DOI: 10.1016/j.bmcl.2016.02.067 BindingDB Entry DOI: 10.7270/Q2C24Z9V
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using FAM-labell...				Bioorg Med Chem 26: 1810-1822 (2018) BindingDB Entry DOI: 10.7270/Q2FF3W1G
Shenyang Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR deletion mutant autophosphorylation in human HCC827 cells after 2 hrs by sandwich ELISA				J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR L858R mutant autophosphorylation in human H3255 cells after 2 hrs by sandwich ELISA				J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co. Itd. Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISA				Bioorg Med Chem Lett 28: 1257-1261 (2018) BindingDB Entry DOI: 10.7270/Q2GB26Q2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGFR deletion mutant autophosphorylation in human PC9 cells after 2 hrs by sandwich ELISA				J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of wild type EGFR phosphorylation in human HaCaT cells incubated for 3 hrs by ELISA method				J Med Chem 59: 6671-89 (2016) Article DOI: 10.1021/acs.jmedchem.5b01985 BindingDB Entry DOI: 10.7270/Q2RF5X00
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor(L858R, T790M) (325/327 > 99%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals Inc US Patent					Assay Description A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...				US Patent US10227342 (2019) BindingDB Entry DOI: 10.7270/Q21Z46Q0
ARIAD Pharmaceuticals Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (T790M) (326/327 > 99%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals Inc US Patent					Assay Description A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...				US Patent US10227342 (2019) BindingDB Entry DOI: 10.7270/Q21Z46Q0
ARIAD Pharmaceuticals Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals Inc US Patent					Assay Description A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...				US Patent US10227342 (2019) BindingDB Entry DOI: 10.7270/Q21Z46Q0
ARIAD Pharmaceuticals Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR L858R/T790M/C797S mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence as...				Eur J Med Chem 148: 221-237 (2018) BindingDB Entry DOI: 10.7270/Q2H70JF4
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay				Bioorg Med Chem 26: 3619-3633 (2018) BindingDB Entry DOI: 10.7270/Q2Z3224Q
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Xi'an Jiaotong University Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence ...				Bioorg Med Chem 26: 2173-2185 (2018) BindingDB Entry DOI: 10.7270/Q2H41V28
Xi'an Jiaotong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Haiyan Pharmaceutical Technology Co. Itd. Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISA				Bioorg Med Chem Lett 28: 1257-1261 (2018) BindingDB Entry DOI: 10.7270/Q2GB26Q2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of EGF-stimulated wild type EGFR autophosphorylation expressed in human A549 cells by sandwich ELISA				J Med Chem 59: 2005-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01633 BindingDB Entry DOI: 10.7270/Q2KS6TDD
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Tsinghua University-Peking University Joint Center for Life Sciences Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR (unknown origin) using Tyr 4 peptide as substrate in presence of ATP by Z-LYTE kinase assay				Bioorg Med Chem 25: 4553-4559 (2017) BindingDB Entry DOI: 10.7270/Q28K7CKS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr)...				ACS Med Chem Lett 9: 1123-1127 (2018) BindingDB Entry DOI: 10.7270/Q2FR00BQ
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Guangzhou Institutes of Biomedicine and Health Curated by ChEMBL					Assay Description Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA				Eur J Med Chem 126: 1107-1117 (2017) Article DOI: 10.1016/j.ejmech.2016.12.006 BindingDB Entry DOI: 10.7270/Q2F47RD5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged wild type EGFR expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as substrate after 1 h...				Eur J Med Chem 152: 298-306 (2018) BindingDB Entry DOI: 10.7270/Q2PC34ZZ
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals Inc US Patent					Assay Description A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...				US Patent US10227342 (2019) BindingDB Entry DOI: 10.7270/Q21Z46Q0
ARIAD Pharmaceuticals Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	409	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA				Bioorg Med Chem 24: 2673-80 (2016) Article DOI: 10.1016/j.bmc.2016.04.032 BindingDB Entry DOI: 10.7270/Q26W9D0T
Fudan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Inhibition of EGF-stimulated wild type EGFR phosphorylation in human LoVo cells incubated for 2 hrs followed by EGF stimulation for 10 mins by ELISA				J Med Chem 60: 839-885 (2017) Article DOI: 10.1021/acs.jmedchem.6b00788 BindingDB Entry DOI: 10.7270/Q2JW8H9T
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Inhibition of wild type EGFR phosphorylation in human LoVo cells preincubated for 2 hrs followed by EGF stimulation measured after 30 mins by ELISA				Bioorg Med Chem Lett 26: 1861-8 (2016) Article DOI: 10.1016/j.bmcl.2016.02.067 BindingDB Entry DOI: 10.7270/Q2C24Z9V
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	494	n/a	n/a	n/a	n/a	n/a	n/a
St. John's University Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR (unknown origin)				Bioorg Med Chem Lett 27: 4832-4837 (2017) BindingDB Entry DOI: 10.7270/Q22Z183X
St. John's University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals Inc US Patent					Assay Description A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...				US Patent US10227342 (2019) BindingDB Entry DOI: 10.7270/Q21Z46Q0
ARIAD Pharmaceuticals Inc US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assay				J Med Chem 57: 8249-67 (2014) Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assay				J Med Chem 57: 8249-67 (2014) Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	4.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assay				J Med Chem 57: 8249-67 (2014) Article DOI: 10.1021/jm500973a BindingDB Entry DOI: 10.7270/Q2ZS2Z4C
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	n/a	n/a	667	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR in human A431 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assay				J Med Chem 60: 2361-2372 (2017) Article DOI: 10.1021/acs.jmedchem.6b01626 BindingDB Entry DOI: 10.7270/Q2FB556R
TU Dortmund University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (327/327 = 100%)^† (Homo sapiens (Human))	BDBM50029668 (AZD-9291 \| OSIMERTINIB \| Osimertinib \| US10085983,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
High Magnetic Field Laboratory Curated by ChEMBL					Assay Description Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysis				J Med Chem 60: 2944-2962 (2017) BindingDB Entry DOI: 10.7270/Q2WQ0680
High Magnetic Field Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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Search BindingMOAD for More Affinity Data:

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output