Affinity Data by PDB ID

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PDB code 4ZXY

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Coagulation factor III/Factor VIIa (fVIIa) (55/55 = 100%)^† (Homo sapiens (Human))	BDBM50098591 (CHEMBL3594305) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human recombinant TF/F7a complex using S2288 as substrate preincubated for 15 mins followed by protein addition measured for 60 mins				J Med Chem 58: 6225-36 (2015) Article DOI: 10.1021/acs.jmedchem.5b00788 BindingDB Entry DOI: 10.7270/Q2DN46TN
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Coagulation factor III/Factor VIIa (fVIIa) (55/55 = 100%)^† (Homo sapiens (Human))	BDBM50098591 (CHEMBL3594305) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of human Tissue factor/factor 7a				J Med Chem 59: 4007-18 (2016) Article DOI: 10.1021/acs.jmedchem.6b00244 BindingDB Entry DOI: 10.7270/Q2B56MNP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Coagulation factor III/Factor VIIa (fVIIa) (55/55 = 100%)^† (Homo sapiens (Human))	BDBM50098592 (CHEMBL3594304) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human recombinant TF/F7a complex using S2288 as substrate preincubated for 15 mins followed by protein addition measured for 60 mins				J Med Chem 58: 6225-36 (2015) Article DOI: 10.1021/acs.jmedchem.5b00788 BindingDB Entry DOI: 10.7270/Q2DN46TN
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output