Affinity Data by PDB ID

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PDB code 5ACW

Identical Ligands in BindingDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metallo-beta-lactamase VIM-2 (VIM-2) (266/266 = 100%)^† (Pseudomonas aeruginosa (g-Proteobacteria))	BDBM50129035 (CHEMBL1778133) Show SMILES Cn1c(S)nnc1C(F)(F)F Show InChI	PDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.32E+5	n/a	n/a	n/a	n/a	n/a	n/a
UiT The Arctic University of Norway Curated by ChEMBL					Assay Description Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate prei...				J Med Chem 58: 8671-82 (2015) Article DOI: 10.1021/acs.jmedchem.5b01289 BindingDB Entry DOI: 10.7270/Q2959KCH
UiT The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metallo-beta-lactamase VIM-2 (VIM-2) (266/266 = 100%)^† (Pseudomonas aeruginosa (g-Proteobacteria))	BDBM50129035 (CHEMBL1778133) Show SMILES Cn1c(S)nnc1C(F)(F)F Show InChI	PDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.45E+5	n/a	n/a	n/a	n/a	n/a
UiT The Arctic University of Norway Curated by ChEMBL					Assay Description Binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR ...				J Med Chem 58: 8671-82 (2015) Article DOI: 10.1021/acs.jmedchem.5b01289 BindingDB Entry DOI: 10.7270/Q2959KCH
UiT The Arctic University of Norway Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output