Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (126/127 > 99%)† (Homo sapiens (Human)) | BDBM188516![]() (BDOIA383) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc | Assay Description The assay used a Cy5 dye-labeled BRD inhibitor PFI-411FP. The synthesis of the probe and the procedure for the assay was reported recently (Hett et a... | Chem Biol 22: 1588-96 (2015) Article DOI: 10.1016/j.chembiol.2015.10.013 BindingDB Entry DOI: 10.7270/Q2V69HC0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (126/127 > 99%)† (Homo sapiens (Human)) | BDBM188516![]() (BDOIA383) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of BRD4 (unknown origin) by fluorescence polarization assay | J Med Chem 60: 5349-5363 (2017) Article DOI: 10.1021/acs.jmedchem.6b01839 BindingDB Entry DOI: 10.7270/Q2B85BCF | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (126/127 > 99%)† (Homo sapiens (Human)) | BDBM188516![]() (BDOIA383) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc | Assay Description Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015). | Chem Biol 22: 1588-96 (2015) Article DOI: 10.1016/j.chembiol.2015.10.013 BindingDB Entry DOI: 10.7270/Q2V69HC0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |