Affinity Data by PDB ID

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PDB code 5CFW

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain-containing protein 4 (126/127 > 99%)^† (Homo sapiens (Human))	BDBM188516 (BDOIA383) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The assay used a Cy5 dye-labeled BRD inhibitor PFI-411FP. The synthesis of the probe and the procedure for the assay was reported recently (Hett et a...				Chem Biol 22: 1588-96 (2015) Article DOI: 10.1016/j.chembiol.2015.10.013 BindingDB Entry DOI: 10.7270/Q2V69HC0
Pfizer					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain-containing protein 4 (126/127 > 99%)^† (Homo sapiens (Human))	BDBM188516 (BDOIA383) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of BRD4 (unknown origin) by fluorescence polarization assay				J Med Chem 60: 5349-5363 (2017) Article DOI: 10.1021/acs.jmedchem.6b01839 BindingDB Entry DOI: 10.7270/Q2B85BCF
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain-containing protein 4 (126/127 > 99%)^† (Homo sapiens (Human))	BDBM188516 (BDOIA383) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).				Chem Biol 22: 1588-96 (2015) Article DOI: 10.1016/j.chembiol.2015.10.013 BindingDB Entry DOI: 10.7270/Q2V69HC0
Pfizer					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output