Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50088174![]() (CHEMBL3427251) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba... | ACS Med Chem Lett 7: 271-6 (2016) Article DOI: 10.1021/acsmedchemlett.5b00432 BindingDB Entry DOI: 10.7270/Q2NS0WTZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (441/441 = 100%)† (Homo sapiens (Human)) | BDBM50088174![]() (CHEMBL3427251) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University School of Pharmacy Curated by ChEMBL | Assay Description Inhibition of BACE1 in human H4 cells stably transfected with APP751 containing Swedish mutation assessed as reduction in Abeta (1 to 40) and Abeta (... | ACS Med Chem Lett 6: 237-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00003 BindingDB Entry DOI: 10.7270/Q2JW8GMF | |||||||||||
More data for this Ligand-Target Pair |