Affinity Data by PDB ID

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PDB code 5ENK

Identical Ligands in BindingDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Beta-secretase 1 (441/441 = 100%)^† (Homo sapiens (Human))	BDBM50088174 (CHEMBL3427251) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of BACE1 in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta 40 or amyloid beta 42 production incuba...				ACS Med Chem Lett 7: 271-6 (2016) Article DOI: 10.1021/acsmedchemlett.5b00432 BindingDB Entry DOI: 10.7270/Q2NS0WTZ
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-secretase 1 (441/441 = 100%)^† (Homo sapiens (Human))	BDBM50088174 (CHEMBL3427251) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Inhibition of BACE1 in human H4 cells stably transfected with APP751 containing Swedish mutation assessed as reduction in Abeta (1 to 40) and Abeta (...				ACS Med Chem Lett 6: 237-8 (2015) Article DOI: 10.1021/acsmedchemlett.5b00003 BindingDB Entry DOI: 10.7270/Q2JW8GMF
Temple University School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output