Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl Curated by ChEMBL | Assay Description Inhibition of recombinant ALK (unknown origin) | J Med Chem 59: 3392-408 (2016) Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl Curated by ChEMBL | Assay Description Inhibition of recombinant ALK (unknown origin) in presence of gamma33-ATP | J Med Chem 59: 3392-408 (2016) Article DOI: 10.1021/acs.jmedchem.6b00064 BindingDB Entry DOI: 10.7270/Q27M09TG | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of ALK (unknown origin) by radiometric assay | Eur J Med Chem 143: 182-199 (2018) BindingDB Entry DOI: 10.7270/Q2B56N9M | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Nerviano Medical Sciences srl US Patent | Assay Description BioKinase buffer was composed of 50 mM HEPES pH 7.5 containing 1 mM MnCl2, 5 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSA. 3x KB is buffer ... | US Patent US9255087 (2016) BindingDB Entry DOI: 10.7270/Q20G3J06 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Nerviano Medical Sciences srl US Patent | Assay Description ALK enzyme needs pre-activation in order to linearize reaction kinetics.i. Kinase Buffer (KB) for ALK.Kinase buffer was composed of 50 mM HEPES pH 7.... | US Patent US10081622 (2018) BindingDB Entry DOI: 10.7270/Q2833V2H | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl US Patent | Assay Description Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 containing 1 mM MnCl2, mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL ... | US Patent US9616059 (2017) BindingDB Entry DOI: 10.7270/Q2TT4T0S | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (314/314 = 100%)† (Homo sapiens (Human)) | BDBM158154![]() (US10081622, Compound 11 | US10370379, Entrectinib ...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Nerviano Medical Sciences srl US Patent | Assay Description ALK enzyme needs pre-activation in order to linearize reaction kinetics.Kinase Buffer (KB) for ALKKinase buffer was composed of 50 mM HEPES pH 7.5 co... | US Patent US9029356 (2015) BindingDB Entry DOI: 10.7270/Q29C6W5G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |