Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5G0O
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM190665(US10759791, Compound 14g | nNOS inhibitor, 3)
Affinity DataKi:  42.6nM ΔG°:  -43.8kJ/molepH: 7.4 T: 37°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM190665(US10759791, Compound 14g | nNOS inhibitor, 3)
Affinity DataKi:  43nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain(Rat)
University of California Irvine

LigandPNGBDBM190665(US10759791, Compound 14g | nNOS inhibitor, 3)
Affinity DataKi:  43nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM190665(US10759791, Compound 14g | nNOS inhibitor, 3)
Affinity DataKi:  736nM ΔG°:  -36.4kJ/molepH: 7.4 T: 37°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, brain [D597N](Rat)
University of California Irvine

LigandPNGBDBM190665(US10759791, Compound 14g | nNOS inhibitor, 3)
Affinity DataKi:  748nM ΔG°:  -36.4kJ/molepH: 7.4 T: 37°CAssay Description:The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)