BindingDB PrimarySearch

Report error Found 29 Enz. Inhib. hit(s) for PDB: 5J89

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 15nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) preincubated with PD-L1 for 15 mins followed by PD-1 addition measured after 90 mins by TR-FRET...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 17nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin) protein-protein interaction measured after 135 mins by TR-FRET assay relative to controlMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand 1(Human)
Universidade De Lisboa

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interaction measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF binding assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of PD1/PDL1 interaction (unknown origin) after 15 mins by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of Ig-tagged human PD1/His-tagged human PDL1 interaction incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand 1(Human)
Universidade De Lisboa

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of PD1/PD-L1 (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Inhibition of PD-1/PDL-1 (unknown origin) bindingMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand 1(Human)
Universidade De Lisboa

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Binding affinity to PDL1 (unknown origin) assessed as reduction in PDL1/PD1 protein-protein interaction preincubated for 15 mins followed by PD1 addi...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand 1(Human)
Universidade De Lisboa

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 18nMAssay Description:Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 22nMAssay Description:Inhibition of human recombinant PD-1/PDL-1 interaction measured by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 55nMAssay Description:A negative control, a positive control and drug administration groups were set up, with two duplicate wells in each group. For the positive control g...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 61nMAssay Description:Inhibition of PD1/PDL1 (unknown origin) protein-protein interaction measured after 15 mins by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 61nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 61nMAssay Description:Inhibition of PD-1/PDL1 (unknown origin) measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 68nMAssay Description:Inhibition of human PD-1/PD-L1 interaction assessed as disruption of PD-1/PD-L1 complex incubated for 2 hrs by Tag-1 Eu3+ and anti-Tag2-XL665 based H...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 96nMAssay Description:Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 resid...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 124nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in CHO-K1 cells transfected with PD-1-YFP/SHP-2-CFP and measured by FRET assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 175nMAssay Description:Example 39: The experimental method and procedure were carried out in accordance with the kit instructions, which were briefly described as follows: ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

IC50: 191nMAssay Description:Inhibition of PD1 (unknown origin)/PDL1 (unknown origin) protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

EC50: >1.00E+4nMAssay Description:Inhibition of human PD1 stably expressed in human Jurkat T cells co-expressing NFAT-induced luciferase/human PDL1 stably expressed in CHOK1 cells co-...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand 1(Human)
Universidade De Lisboa

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

Kd: 135nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

EC50: >1.00E+4nMAssay Description:Inhibition of human PD-1/PD-L1 interaction in human Jurkat cells expressing PD-1/NFAT/Luc cocultured with CHO-K1 cells expressing PD-L1/aAPC assessed...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand/protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

EC50: 2.76E+3nMAssay Description:Inhibition of PD1/PDL1 interaction in human Jurkat cells co-cultured with human U2OS cells expressing PDL1 assessed as reduction in SHP1 recruitment ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Programmed cell death 1 ligand 1(Human)
Universidade De Lisboa

Curated by ChEMBL

BDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)

Kd: 37nMAssay Description:Binding affinity towards His-tagged recombinant human PD-L1 measured by MST dimerization binding assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 29 hits

Targets 2▿
- Programmed cell death 1 ligand/protein 1 23
- Programmed cell death 1 ligand 1 6
Publications 24▿
- J Med Chem 62: 7250-7263 (2019) 3
- J Med Chem 64: 16020-16045 (2021) 2
- Eur J Med Chem 236: (2022) 2
- Bioorg Med Chem 46: (2021) 2
- J Med Chem 64: 16687-16702 (2021) 1
- J Med Chem 64: 7390-7403 (2021) 1
- Bioorg Med Chem Lett 52: (2021) 1
- Bioorg Med Chem Lett 29: 2464-2467 (2019) 1
- J Med Chem 63: 15389-15398 (2020) 1
- J Med Chem 64: 8391-8409 (2021) 1
- US Patent US20230303494 (2023) 1
- Bioorg Med Chem 33: (2021) 1
- Eur J Med Chem 213: (2021) 1
- Eur J Med Chem 213: (2021) 1
- Bioorg Med Chem 73: (2022) 1
- J Med Chem 62: 1715-1730 (2019) 1
- J Med Chem 63: 15946-15959 (2020) 1
- J Med Chem 61: 10957-10975 (2018) 1
- US Patent US20240043392 (2024) 1
- US Patent US9872852 (2018) 1
- J Med Chem 60: 5857-5867 (2017) 1
- Bioorg Med Chem Lett 30: (2020) 1
- J Med Chem 64: 7646-7666 (2021) 1
- J Med Chem 63: 8338-8358 (2020) 1
Institutions 15▿
- China Pharmaceutical University 6
- Jagiellonian University 4
- Southern Medical University 4
- Univ. Lille 2
- University of Naples Federico II 2
- Zhejiang University 2
- Xi'An Xinton Pharmaceutcal Research 1
- Shenyang Pharmaceutical University 1
- Bristol-Myers Squibb 1
- Academy of Military Medical Sciences 1
- Universidade De Lisboa 1
- Acharya & Bm Reddy College of Pharmacy 1
- Japan Tobacco 1
- Chinese Academy of Medical Sciences & Peking Union Medical College 1
- Shanghai Jiao Tong University 1
Affinity: 15 to 1.0E+4 nM▿
- IC50 24
- Kd 2
- EC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1