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Report error Found 4 Enz. Inhib. hit(s) for PDB: 5MLS
TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50307858((S)-1-((R)-2-amino-3-phenylpropanoyl)-N-(3-chlorob...)
Affinity DataKi:  90nMAssay Description:Inhibition of human alpha-thrombin using tPa (CH3SO2-D-Cha-Gly-Arg-pNA.AcOH) as chromogenic substrate by kinetic photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50307858((S)-1-((R)-2-amino-3-phenylpropanoyl)-N-(3-chlorob...)
Affinity DataKi:  180nMAssay Description:Binding affinity to human thrombin by standard kinetic photometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50133531((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  250nMAssay Description:Inhibitory potency against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProthrombin(Human)
The State University of New York

Curated by ChEMBL
LigandPNGBDBM50133531((S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  250nMAssay Description:Inhibitory constant evaluated against thrombin (Factor IIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)