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Report error Found 4 Enz. Inhib. hit(s) for PDB: 5OVE
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50:  263nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50:  304nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetSon of sevenless homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human His-tagged SOS1 by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657340(6,7-dimethoxy-N-[(1R)-1-(1-naphthyl)ethyl]quinazol...)
Affinity DataIC50:  693nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails US Patent
PDB3D3D Structure (crystal)