Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 3 Enz. Inhib. hit(s) for PDB: 5QCW
TargetBeta-secretase 1 [1-453](Human)
Novartis

LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50:  590nMpH: 4.5 T: 22°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetBeta-secretase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)