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Report error Found 5 Enz. Inhib. hit(s) for PDB: 5UT4
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50:  0.480nMAssay Description:Competitive inhibition of JAK2 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of full length JAK2 V617F mutant (unknown origin) by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of full length wild type JAK2 (unknown origin) by JAK radiometric filter binding kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of recombinant GST tagged JAK2 protein after 60 mins using FITC-GGEEEEYFELVKKKK-NH2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315231(4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataKd:  4.20E+4nMAssay Description:Binding affinity to wild type JAK2 JH2 domain (unknown origin) by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)