Affinity DataKi: 600nMAssay Description:Inhibition of human TS by spectrophotometric analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 4.50E+4nMAssay Description:Inhibitory activity against thymidylate synthase in murine tumor cellsMore data for this Ligand-Target Pair
TargetBifunctional purine biosynthesis protein ATIC/Thymidylate synthase/Trifunctional purine biosynthetic protein adenosine-3(Human)
Hebei Medical University
Curated by ChEMBL
Hebei Medical University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of TS/AICARFTase/GARFTase in human KB cells assessed as reduction in cell proliferation in folate free medium after 72 hrs in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory activity against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80E+4nMAssay Description:Inhibition of human TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibitory activity against thymidylate synthase of Streptococcus faeciumMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibitory concentration of the compound against recombinant human TS (Thymidylate synthase).More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibitory concentration of the compound for TS in humanMore data for this Ligand-Target Pair
