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Report error Found 12 Enz. Inhib. hit(s) for PDB: 5ZRF
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human DNA topoisomerase 2beta after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedDrugBank
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human topoisomerase-2B after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedDrugBank
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentrationMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  3.80E+4nMAssay Description:In vitro activity against mammalian topoisomerase II measured as ATP-dependent unknotting of P4 DNA compared to enzyme and DNA controlMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  5.04E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  5.60E+4nMAssay Description:Concentration of compound at which inhibitory activity detected against DNA topoisomerase IIMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  810nMAssay Description:Tested for inhibitory activity against Topoisomerase II isolated from HeLa cells by using SDS-K+ precipitation methodMore data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  810nMAssay Description:Inhibitory activity against HeLa cell Topoisomerase IIMore data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  810nMAssay Description:Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation methodMore data for this Ligand-Target Pair
In DepthDetails
ArticlePDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  810nMAssay Description:Inhibitory activity in a cell-free assay of DNA cleavage mediated by purified HeLa cell topoisomerase II.More data for this Ligand-Target Pair
In DepthDetails
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-beta(Human)
Port Said University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50: >7.00E+4nMAssay Description:Inhibition of calf thymus DNA/ethidium bromide complex formation.More data for this Ligand-Target Pair
In DepthDetails
ArticleDrugBank
PDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataEC50:  810nMAssay Description:Tested for inhibition of topoisomerase II isolated from HeLa cells by DNA-cleavage assayMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)