Affinity DataKi: 3.80nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-betaMore data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-gammaMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Agonistic activity of the compound towards retinoid X receptor-alphaMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of [3H]-9-cis-RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Binding affinity towards Retinoic acid receptor RXR-gamma by displacing 3.4 nM 3[H]-9-cis-RAMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human GST-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of [3H]-9-cis-retinoic acid binding to human retinoid X receptor alpha ligand-binding domain expressed in E. coliMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Binding affinity against retinoic Acid X alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nM EC50: 900nMpH: 8.0 T: 2°CAssay Description:Binding affinity (IC50) was evaluated using scintillation proximity assay with radiolabeled ligand and biotinylated receptor. Because the scintillant...More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Mus musculus)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Inhibition of [3H]-ATRA binding to mouse Retinoic acid receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 70nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
Affinity DataEC50: 59nMpH: 7.5 T: 2°CAssay Description:The assay measures ligand-mediated interaction of the SRC-1 peptide with the FXR ligand binding domain, using biotinylated FXR LBD coupled to allophy...More data for this Ligand-Target Pair
Affinity DataEC50: 65nMAssay Description:The cell-based assay measures the ligand-mediated luminescense resulting from FXR-induced transcription of a luciferase reporter. FXR and the lucifer...More data for this Ligand-Target Pair
Affinity DataKd: 9nMAssay Description:Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Inhibition of [3H]-9-cis-RA binding to mouse Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Binding affinity against retinoic Acid X beta receptors cotransfected into CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Binding affinity against retinoic Acid X gamma receptors cotransfected into CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 219nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Transcriptional activation of Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Effective concentration against Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Binding affinity against retinoic Acid X alpha receptors cotransfected into CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Effective concentration against RXR-alpha receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Dissociation constant for binding to Retinoid X receptor betaMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Transcriptional activation of Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Transcriptional activation of Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 140nMAssay Description:Transcriptional activation of Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Dissociation constant for binding to Retinoid X receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Mus musculus)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataKd: 32nMAssay Description:Dissociation constant for binding to Retinoid X receptor alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at FXR (unknown origin) by coactivator recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 900nMAssay Description:Agonist activity at FXR (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.56E+3nMAssay Description:Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by is...More data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching methodMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformationMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after ...More data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair