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Report error Found 4 Enz. Inhib. hit(s) for PDB: 6H8P
TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM4A expressed in Escherichia coli pre-incubated for 4 hrs before substrate addition and measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of recombinant His-tagged JMJD2A expressed in Escherichia coli Rosetta 2 (DE3) pLysS cells by formaldehyde dehydrogenase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of KDM4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)