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Report error Found 3 Enz. Inhib. hit(s) for PDB: 6INK
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525175(CHEMBL4520636)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525167(CHEMBL4556365)
Affinity DataIC50:  510nMAssay Description:Inhibition of recombinant human PDE4D catalytic domain using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50525175(CHEMBL4520636)
Affinity DataIC50:  2.73E+3nMAssay Description:Inhibition of PDE4 in human PBMC assessed as reduction in LPS-stimulated TNFalpha production preincubated for 1 hr followed by LPS stimulation and me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)