Affinity Data by PDB ID

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PDB code 6NAO

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclic GMP-AMP synthase (362/362 = 100%)^† (Homo sapiens)	BDBM50250108 (CHEMBL4096573) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...				PLoS ONE 12: 1-16 (2017) Article DOI: 10.1371/journal.pone.0184843
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclic GMP-AMP synthase (362/362 = 100%)^† (Homo sapiens)	BDBM50250108 (CHEMBL4096573) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...				PLoS ONE 12: 1-16 (2017) Article DOI: 10.1371/journal.pone.0184843
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclic GMP-AMP synthase (362/362 = 100%)^† (Homo sapiens)	BDBM50250108 (CHEMBL4096573) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assay				PLoS ONE 12: 1-16 (2017) Article DOI: 10.1371/journal.pone.0184843
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output