Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclic GMP-AMP synthase (362/362 = 100%)† (Homo sapiens) | BDBM50250108![]() (CHEMBL4096573) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assay | PLoS ONE 12: 1-16 (2017) Article DOI: 10.1371/journal.pone.0184843 BindingDB Entry DOI: 10.7270/Q2WQ067J | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cyclic GMP-AMP synthase (362/362 = 100%)† (Homo sapiens) | BDBM50250108![]() (CHEMBL4096573) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc... | PLoS ONE 12: 1-16 (2017) Article DOI: 10.1371/journal.pone.0184843 BindingDB Entry DOI: 10.7270/Q2WQ067J | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cyclic GMP-AMP synthase (362/362 = 100%)† (Homo sapiens) | BDBM50250108![]() (CHEMBL4096573) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc... | PLoS ONE 12: 1-16 (2017) Article DOI: 10.1371/journal.pone.0184843 BindingDB Entry DOI: 10.7270/Q2WQ067J | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |