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Report error Found 4 Enz. Inhib. hit(s) for PDB: 6O9O
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50509592(CHEMBL4460946)
Affinity DataKi:  6nMAssay Description:Uncompetitive inhibition of SMYD3 (unknown origin) assessed as inhibitory constant incubated for 60 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50509592(CHEMBL4460946)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant N-terminal FLAG/His-tagged SMYD3 (unknown origin) expressed in baculovirus infected insect cells using 3H-SAM as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50509592(CHEMBL4460946)
Affinity DataIC50:  67nMAssay Description:Inhibition of SMYD3 (unknown origin) assessed as reduction in histone H4 methylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50509592(CHEMBL4460946)
Affinity DataEC50:  39nMAssay Description:Inhibition of recombinant SMYD3 (unknown origin) transfected in human HEK293 cells assessed as reduction in MEKK2 methylation incubated for 24 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)