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Report error Found 41 Enz. Inhib. hit(s) for PDB: 6PZ1
TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  70nMAssay Description:Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  150nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  150nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  150nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  200nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  210nMAssay Description:The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  210nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  210nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  216nMAssay Description:Inhibition of recombinant human His-tagged IDO1 (Ala2 to Gly403 residues) expressed in Escherichia coli using tryptophan as substrate preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  370nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 1 hr by absorbance b...More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human recombinant IDO1 assessed as reduction in kynurenine production incubated fro 15 mins using L-Trp substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of recombinant human full length IDO1 by mass spectrometry based enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  410nMAssay Description:Inhibition of recombinant full-length human IDO1 by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human THP1 cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human THP1 cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  1.80E+3nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of IDO1 in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine production after 24 hrs by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine production after 24 hrs by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to ferrous form of human recombinant IDO-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to ferrous form of human recombinant IDO-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataKd:  2.23E+4nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  150nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygen and presence of tryptophanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM310195((-)-(R)-3-(5-fluoro-1H- indol-3-yl)pyrrolidine- 2,...)
Affinity DataKd:  160nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIndoleamine 2,3-dioxygenase 1(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataKd:  320nMAssay Description:Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)