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Report error Found 9 Enz. Inhib. hit(s) for PDB: 6QXG
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  10nMAssay Description:Apparent Ki value of the compound was measured by competitive inhibition of Thymidylate Synthases from Ehrlich Carcinoma cells of mouseMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  14nMAssay Description:Inhibition of human thymidylate synthase expressed in Escherichia coli incubated for 1 hr by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  20nMAssay Description:Time-independent inhibition of thymidylate synthase from parenteral L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  20nMAssay Description:Apparent Ki value of the compound was measured by competitive inhibition of Thymidylate Synthases from L1210 cells of mouseMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataKi:  30nMAssay Description:Time-independent inhibition of thymidylate synthase from FdUrd-resistant L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataIC50:  8nMAssay Description:Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in permeabilised cells.More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataIC50:  17nMAssay Description:Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in intact cells.More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataIC50:  42nMAssay Description:Inhibition of cellular thymidylate synthase activity of murine leukemia cell line (L1210) in permeabilised cells.More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
TargetThymidylate synthase(Mouse)
Polish Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50022238((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cellular thymidylate synthase activity of mouse fibroblast (L929 TK-) in intact cells.More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)