Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cysteinyl leukotriene receptor 1 (196/225 = 87%)† (GUINEA PIG) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Compound was evaluated in vitro for the binding of Cysteinyl leukotriene receptor 1 to guinea pig lung membranes | Bioorg Med Chem Lett 9: 2773-8 (1999) Article DOI: 10.1016/s0960-894x(99)00461-8 BindingDB Entry DOI: 10.7270/Q2MP52G3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor 1 (196/225 = 87%)† (GUINEA PIG) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes | Bioorg Med Chem Lett 8: 3577-82 (1999) Article DOI: 10.1016/s0960-894x(98)00654-4 BindingDB Entry DOI: 10.7270/Q2833R5M | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor (89/89 = 100%)† (Homo sapiens (Human)) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes | Bioorg Med Chem Lett 8: 1791-6 (1998) Article DOI: 10.1016/s0960-894x(98)00273-x BindingDB Entry DOI: 10.7270/Q2N3004B | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor 1 (196/225 = 87%)† (GUINEA PIG) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.0440 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth... | J Med Chem 60: 5235-5266 (2017) Article DOI: 10.1021/acs.jmedchem.6b01287 BindingDB Entry DOI: 10.7270/Q2T43WDQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor (89/89 = 100%)† (Homo sapiens (Human)) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.0440 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileum | J Med Chem 31: 84-91 (1988) Article DOI: 10.1021/jm00396a013 BindingDB Entry DOI: 10.7270/Q20K2BSP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor (89/89 = 100%)† (Homo sapiens (Human)) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University Curated by ChEMBL | Assay Description Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L... | Bioorg Med Chem 18: 5519-27 (2010) Article DOI: 10.1016/j.bmc.2010.06.047 BindingDB Entry DOI: 10.7270/Q26D5TZ0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor 1 (196/225 = 87%)† (GUINEA PIG) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Curated by ChEMBL | Assay Description Binding affinity of the compound towards Cysteinyl leukotriene D4 receptor (cysLT1) was measured by the displacement of [3H]-LTD4 radioligand | J Med Chem 41: 1439-45 (1998) Article DOI: 10.1021/jm970180w BindingDB Entry DOI: 10.7270/Q2WH2P4P | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor (89/89 = 100%)† (Homo sapiens (Human)) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Setsunan University Curated by ChEMBL | Assay Description Antagonist activity at human CysLT1 | J Med Chem 58: 6093-113 (2015) Article DOI: 10.1021/acs.jmedchem.5b00741 BindingDB Entry DOI: 10.7270/Q2QJ7K27 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor (89/89 = 100%)† (Homo sapiens (Human)) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometry | J Med Chem 60: 5235-5266 (2017) Article DOI: 10.1021/acs.jmedchem.6b01287 BindingDB Entry DOI: 10.7270/Q2T43WDQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor (89/89 = 100%)† (Homo sapiens (Human)) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica Curated by ChEMBL | Assay Description Antagonist activity against CysLT1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pr... | ACS Med Chem Lett 7: 335-9 (2016) Article DOI: 10.1021/acsmedchemlett.5b00482 BindingDB Entry DOI: 10.7270/Q27D2X19 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cysteinyl leukotriene receptor 1 (196/225 = 87%)† (GUINEA PIG) | BDBM50023198![]() (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article | n/a | n/a | n/a | 0.000214 | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Dissociation constant for CysLT1 receptor was determined by the displacement of [3H]LTD4 from guinea pig lung membranes | Bioorg Med Chem Lett 7: 1331-1336 (1997) Article DOI: 10.1016/S0960-894X(97)00219-9 BindingDB Entry DOI: 10.7270/Q2JD4WTR | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |