Affinity Data by PDB ID

PDB code 6RZ4

Identical Ligands in BindingDB

Found 11 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cysteinyl leukotriene receptor 1 (196/225 = 87%)^† (GUINEA PIG)	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Compound was evaluated in vitro for the binding of Cysteinyl leukotriene receptor 1 to guinea pig lung membranes				Bioorg Med Chem Lett 9: 2773-8 (1999) Article DOI: 10.1016/s0960-894x(99)00461-8 BindingDB Entry DOI: 10.7270/Q2MP52G3
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor 1 (196/225 = 87%)^† (GUINEA PIG)	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes				Bioorg Med Chem Lett 8: 3577-82 (1999) Article DOI: 10.1016/s0960-894x(98)00654-4 BindingDB Entry DOI: 10.7270/Q2833R5M
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor (89/89 = 100%)^† (Homo sapiens (Human))	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Ability to antagonize LTD4 receptors isolated from guinea pig lung membranes				Bioorg Med Chem Lett 8: 1791-6 (1998) Article DOI: 10.1016/s0960-894x(98)00273-x BindingDB Entry DOI: 10.7270/Q2N3004B
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor 1 (196/225 = 87%)^† (GUINEA PIG)	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.0440	n/a	n/a	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting meth...				J Med Chem 60: 5235-5266 (2017) Article DOI: 10.1021/acs.jmedchem.6b01287 BindingDB Entry DOI: 10.7270/Q2T43WDQ
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor (89/89 = 100%)^† (Homo sapiens (Human))	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.0440	n/a	n/a	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileum				J Med Chem 31: 84-91 (1988) Article DOI: 10.1021/jm00396a013 BindingDB Entry DOI: 10.7270/Q20K2BSP
Ono Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor (89/89 = 100%)^† (Homo sapiens (Human))	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...				Bioorg Med Chem 18: 5519-27 (2010) Article DOI: 10.1016/j.bmc.2010.06.047 BindingDB Entry DOI: 10.7270/Q26D5TZ0
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor 1 (196/225 = 87%)^† (GUINEA PIG)	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Binding affinity of the compound towards Cysteinyl leukotriene D4 receptor (cysLT1) was measured by the displacement of [3H]-LTD4 radioligand				J Med Chem 41: 1439-45 (1998) Article DOI: 10.1021/jm970180w BindingDB Entry DOI: 10.7270/Q2WH2P4P
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor (89/89 = 100%)^† (Homo sapiens (Human))	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Setsunan University Curated by ChEMBL					Assay Description Antagonist activity at human CysLT1				J Med Chem 58: 6093-113 (2015) Article DOI: 10.1021/acs.jmedchem.5b00741 BindingDB Entry DOI: 10.7270/Q2QJ7K27
Setsunan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor (89/89 = 100%)^† (Homo sapiens (Human))	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometry				J Med Chem 60: 5235-5266 (2017) Article DOI: 10.1021/acs.jmedchem.6b01287 BindingDB Entry DOI: 10.7270/Q2T43WDQ
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor (89/89 = 100%)^† (Homo sapiens (Human))	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Antagonist activity against CysLT1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of LTD4-induced calcium mobilization pr...				ACS Med Chem Lett 7: 335-9 (2016) Article DOI: 10.1021/acsmedchemlett.5b00482 BindingDB Entry DOI: 10.7270/Q27D2X19
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cysteinyl leukotriene receptor 1 (196/225 = 87%)^† (GUINEA PIG)	BDBM50023198 (8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	n/a	0.000214	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Dissociation constant for CysLT1 receptor was determined by the displacement of [3H]LTD4 from guinea pig lung membranes				Bioorg Med Chem Lett 7: 1331-1336 (1997) Article DOI: 10.1016/S0960-894X(97)00219-9 BindingDB Entry DOI: 10.7270/Q2JD4WTR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

Reorder this table by ec50
Reorder this table by ic50
Reorder this table by Kd
Reorder this table by pH
Reorder this table by T
Reorder this table by ΔH°
Reorder this table by -TΔS°
Change energy units to: kcal/mole

Search BindingMOAD for More Affinity Data:

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output