Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 29 Enz. Inhib. hit(s) for PDB: 7DU8
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human wild type RETMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human RET V804L mutantMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human RET V804M mutantMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-3C fused human RET (705 to 1013 residues) expressed in sf9 baculovirus expression system using 5-FAM- peptide as substrate preincub...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  1.98nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6/Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  2.07nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  2.17nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of wild type rearranged during transfection kinase (unknown origin) preincubated for 1 hr followed by addition of development agent incuba...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  5.09nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  14nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  14nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  14nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  14nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  15.1nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  24.1nMMore data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  24.1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  24.1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  24.1nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  29.3nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  34.1nMMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Jiangsu Chia Tai Fenghai Pharmaceutical

US Patent
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  84.2nMMore data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  473nMMore data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  531nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  531nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  531nMMore data for this Ligand-Target Pair
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  531nMAssay Description:RET G810R: The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assay...More data for this Ligand-Target Pair