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Report error Found 4 Enz. Inhib. hit(s) for PDB: 7EW0
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM427481(US10544136, Compound 265)
Affinity DataEC50: <0.5nMAssay Description:The method involves contacting the receptor with a suitable concentration of an inventive compound to bring about activation of the receptor. The con...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at S1P1 (unknown origin) expressed in CHO-K1 cells using CC4-AM as substrate assessed as inhibition of forskolin-induced cAMP accumu...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) assessed as reduction in forskolin-induced cAMP accumulation after 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  0.410nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) after 120 mins in presence of [35S]-GTPgammaS by Topcount methodMore data for this Ligand-Target Pair