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Found
1
Enz. Inhib. hit(s) for PDB:
7NA1
Target
E3 ubiquitin-protein ligase Mdm2 [17-125]
(Human)
Merck Sharp & Dohme
US Patent
Ligand
BDBM215010
(8-(1-benzo- thiophen-5-yl)- 7-(4-chloro- benzyl)-6...)
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Affinity Data
IC50: 259nM
T: 25°C
Assay Description:
An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...
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US Patent
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