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Report error Found 19 Enz. Inhib. hit(s) for PDB: 7XVY
TargetEstrogen receptor beta(Rat)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50364075(CHEMBL1950809)
Affinity DataKi:  1.82nMAssay Description:Displacement of [3H]E2 from rat ERbeta1 after 90 minsMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  0.660nMAssay Description:Agonist activity at human ER-beta transfected in HEC-1 cells assessed as transcriptional activation incubated for 24 hrs by dual luciferase reporter ...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50364075(CHEMBL1950809)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at human ERbeta expressed in U2OS cells coexpressing pCMX-hSRC3 assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50364075(CHEMBL1950809)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at human ERbeta expressed in HEC-1 cells coexpressing beta-gal assessed as luciferase activity after 24 hrs by reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50364075(CHEMBL1950809)
Affinity DataEC50:  32.3nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  16.7nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled ERbeta ligand binding domain expressed in Escherichia coli BL21 cells assessed as recruitmen...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50364075(CHEMBL1950809)
Affinity DataEC50:  0.760nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  0.710nMAssay Description:Agonist activity at human N-His6-tagged terbium-labelled NRID-SRC3 of ERbeta ligand binding domain expressed in Escherichia coli BL21 cells after 1 h...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  20nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  7.20E+5nMAssay Description:Activation of human ERbeta assessed as induction of transcriptional activation incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  8.90E+5nMAssay Description:Activation of human ERbeta assessed as induction of transcriptional activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  1.90nMAssay Description:Binding affinity to human GST-tagged estrogen receptor beta ligand binding domain after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at estrogen receptor beta (unknown origin) after 22 hrs by cell-based luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at estrogen receptor beta (unknown origin) assessed as inhibition of estradiol-induced response after 22 hrs by cell-based lucife...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  0.820nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  6nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor BetaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  0.850nMAssay Description:Agonist activity at ERbeta expressed in human HEC1 cells assessed as transcriptional potency after 24 hrs by luciferase-beta galactosidase reporter g...More data for this Ligand-Target Pair