Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 5 Enz. Inhib. hit(s) for PDB: 7Z1G
TargetGlycogen synthase kinase-3 beta(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human C-terminal his tagged GSK3beta (26 to 383 residues) expressed in Escherichia coli using GYSI(YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE) as pe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGlycogen synthase kinase-3 beta(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  4.62E+3nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGlycogen synthase kinase-3 beta(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataKd:  214nMAssay Description:Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGlycogen synthase kinase-3 beta(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to human C-terminal his tagged GSK3beta (26 to 383 residues) expressed in Escherichia coli assessed as apparent dissociation constan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGlycogen synthase kinase-3 beta(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataKd:  38nMAssay Description:Binding affinity to human C-terminal his tagged GSK3beta (26 to 383 residues) expressed in Escherichia coli at 12.5 uM by radiometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)