Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 4 Enz. Inhib. hit(s) for PDB: 8GDS
TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50: <100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50:  340nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM380028(4-{4-[2-(2,3-dihydro- 1H-indol-1-yl)-2- oxoethyl]p...)
Affinity DataIC50:  550nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
PDB3D3D Structure (crystal)