Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 26 Enz. Inhib. hit(s) for PDB: 8ST4
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  2.66nMMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  6.80nMMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Swiss Federal Institute of Technology Zurich

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rat)
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  39nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rat)
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  41nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  44nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Swiss Federal Institute of Technology Zurich

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  45nMAssay Description:Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  58nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  83nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi:  99nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Swiss Federal Institute of Technology Zurich

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  2.40E+4nMAssay Description:Agonist activity at rat alpha4beta2 expressed in Xenopus oocytes at -60 mV holding potential by electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.90E+4nMAssay Description:Inhibition of [3H]-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Swiss Federal Institute of Technology Zurich

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  8.70E+4nMAssay Description:Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.00E+5nMAssay Description:Agonist activity at alpha4beta2 nAChR low sensitivity formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at alpha4beta2 nAChR high sensitivity formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  7.00E+4nMAssay Description:Agonist activity at human alpha-4-beta-2 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.60E+3nMAssay Description:Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  4.43E+5nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.00E+5nMAssay Description:Agonist activity at human alpha4beta2 nAChR low affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.00E+5nMAssay Description:Agonist activity at human alpha4beta2 nAChR in (alpha4)3(beta2)2 stoichiometry formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  400nMAssay Description:Agonist activity at human alpha4beta2 nAChR high affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holdin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Swiss Federal Institute of Technology Zurich

Curated by ChEMBL
LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  2.70E+5nMAssay Description:Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM10759(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR in (alpha4)2(beta2)3 stoichiometry formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)