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Found 105 Enz. Inhib. hit(s) for PDB: 2W3A
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  0.00600nMAssay Description:Binding affinity to DHFR (unknown origin) by NMR analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  10nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  195nMAssay Description:Inhibition of human dihydrofolate reductase (DHFR) enzymeMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.38E+3nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3.09E+3nMpH: 7.2Assay Description:Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3.09E+3nMAssay Description:Inhibition of dihydrofolate reductase from bovine liverMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  3.09E+3nMpH: 7.2Assay Description:Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.91E+4nMAssay Description:Inhibition of human DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in p...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.91E+4nMAssay Description:Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spect...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  4.58E+4nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in NADPH oxidation using dihydrofolate as substrate preincubated for 5 mins followed by su...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  4.80E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetB-cell CLL/lymphoma 9 protein(Homo sapiens)TBA
LigandPNGBDBM50408056(CHEMBL5274911)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of Rat liver Dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
In DepthDetails
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM50405623(CHEMBL5287474)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from Neisseria gonorrhoeaeMore data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  27nMAssay Description:Antibacterial activity of the compound against TMP-Resistant Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405216(CHEMBL5290029)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from ratMore data for this Ligand-Target Pair
In DepthDetails
TargetSteryl-sulfatase(Homo sapiens (Human))TBA
LigandPNGBDBM10020((2-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  46nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  75nMAssay Description:Inhibitory activity of the compound against TMP-susceptible DHFR from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  123nMAssay Description:Inhibition of DHFR using dihydrofolate as substrate following 3 mins substrate preincubation measured after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  144nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  144nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from rat liver.More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Mycobacterium aviumMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  300nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determined; Range : 260-350More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50405895(CHEMBL5279971)
Affinity DataIC50:  465nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase at 10e8 MMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM459441(US10752635, Example 3, Peak 1 | US11492354, Exampl...)
Affinity DataIC50:  530nMAssay Description:Inhibitory activity against Dihydrofolate reductase obtained from rat liver; Range 260-370More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  900nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  900nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by workers at Hoffman-LaRoche)More data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))TBA
LigandPNGBDBM50054132(2-[6-(4-Chloro-phenyl)-5-oxo-6,7-dihydro-5H-pyrrol...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of rat liver Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails
TargetNADP-dependent malic enzyme(Homo sapiens (Human))TBA
LigandPNGBDBM50405825(CHEMBL5286488)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase in rat liverMore data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporium parvum of bovine originMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondiiMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.80E+3nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined; Range : 2400-3300More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  3.40E+3nMAssay Description:Compound was evaluated as inhibitor of human Dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetB-cell CLL/lymphoma 9 protein(Homo sapiens)TBA
LigandPNGBDBM50409771(CHEMBL5272391)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Cryptosporium parvum of human originMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50405627(CHEMBL5281537)
Affinity DataIC50:  6.08E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) enzyme from rat liverMore data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis cariniiMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.30E+4nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 10000-16000More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.90E+4nMAssay Description:Tested for inhibition of TMP-Resistant Dihydrofolate reductase from Staphylococcus aureus 157/4696.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.45E+4nMAssay Description:Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  3.22E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory concentration against rat liver (RL) dihydrofolate reductases (DHFR)More data for this Ligand-Target Pair
TargetB-cell CLL/lymphoma 9 protein(Homo sapiens)TBA
LigandPNGBDBM50410185(CHEMBL5278414)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Neisseria gonorrhoeae Dihydrofolate reductase(DHFR)More data for this Ligand-Target Pair
In DepthDetails
TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DHFR assessed as NADPH consumption for conversion of dihydrofolic acid to tetrahydrofolic acid after 6 mins every 5 sec by UV-Vis...More data for this Ligand-Target Pair
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