BindingDB logo
myBDB logout

PubMed code 10229625

Compile data set for download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076389
PNG
((1S,2S)-2-[(R)-Amino-carboxy-(9-methyl-9H-xanthen-...)
Show SMILES CC1c2ccccc2Oc2cccc(c12)[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c1-10-11-5-2-3-7-15(11)26-16-8-4-6-13(17(10)16)20(21,19(24)25)14-9-12(14)18(22)23/h2-8,10,12,14H,9,21H2,1H3,(H,22,23)(H,24,25)/t10?,12-,14-,20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50049748
PNG
((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50069111
PNG
((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Show SMILES N[C@@H](C[C@H](CC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H21NO4/c20-17(19(23)24)12-15(18(21)22)11-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,20H2,(H,21,22)(H,23,24)/t15-,17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human Metabotropic glutamate receptor 2


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076393
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-phenyl-c...)
Show SMILES N[C@@H]([C@@H]1[C@H]([C@@H]1c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.90E+3n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50053585
PNG
((S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(O)c1
Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15)/t7-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076392
PNG
((1S,2S)-2-((S)-1-Amino-1-carboxy-ethyl)-cyclopropa...)
Show SMILES C[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-7(8,6(11)12)4-2-3(4)5(9)10/h3-4H,2,8H2,1H3,(H,9,10)(H,11,12)/t3-,4-,7-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.70E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076395
PNG
((1R,2S,4R)-4-Amino-cyclopentane-1,2,4-tricarboxyli...)
Show SMILES N[C@@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.80E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076390
PNG
((S)-2-Amino-4-carboxy-pentanedioic acid | CHEMBL38...)
Show SMILES N[C@@H](CC(C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO6/c7-3(6(12)13)1-2(4(8)9)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)(H,12,13)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.02E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50076395
PNG
((1R,2S,4R)-4-Amino-cyclopentane-1,2,4-tricarboxyli...)
Show SMILES N[C@@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.15E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50076394
PNG
(2-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic aci...)
Show SMILES NC1(CC2CCC1C2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-9(8(13)14)3-4-1-2-5(9)6(4)7(11)12/h4-6H,1-3,10H2,(H,11,12)(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.00E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50034503
PNG
((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 3.89E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.58E+5n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2 (mGluR2)


(Homo sapiens (Human))
BDBM50076391
PNG
(7-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic aci...)
Show SMILES NC1(C2CCC1C(C2)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-9(8(13)14)4-1-2-6(9)5(3-4)7(11)12/h4-6H,1-3,10H2,(H,11,12)(H,13,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50076391
PNG
(7-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic aci...)
Show SMILES NC1(C2CCC1C(C2)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c10-9(8(13)14)4-1-2-6(9)5(3-4)7(11)12/h4-6H,1-3,10H2,(H,11,12)(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%