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PubMed code 10360749

Compile data set for download or QSAR
Found 97 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50031392
PNG
((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-h...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C34H57N11O8/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40)/t21-,22-,23-,24-,25-,26-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077725
PNG
(5-[(E)-3-(4-Fluoro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(F)cc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46FN11O5/c37-25-16-13-22(14-17-25)15-18-29(49)45-36-46-31(47-48-36)34(53)44-28(21-24-10-5-2-6-11-24)33(52)42-26(12-7-19-41-35(39)40)32(51)43-27(30(38)50)20-23-8-3-1-4-9-23/h1,3-4,8-9,13-18,24,26-28H,2,5-7,10-12,19-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077730
PNG
(CHEMBL284498 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H42N8O4/c31-26(39)24(17-20-9-3-1-4-10-20)37-28(41)23(14-8-16-35-30(32)33)36-29(42)25(18-21-11-5-2-6-12-21)38-27(40)22-13-7-15-34-19-22/h1,3-4,7,9-10,13,15,19,21,23-25H,2,5-6,8,11-12,14,16-18H2,(H2,31,39)(H,36,42)(H,37,41)(H,38,40)(H4,32,33,35)/t23-,24-,25-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077723
PNG
(5-[(E)-3-(4-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(Cl)cc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46ClN11O5/c37-25-16-13-22(14-17-25)15-18-29(49)45-36-46-31(47-48-36)34(53)44-28(21-24-10-5-2-6-11-24)33(52)42-26(12-7-19-41-35(39)40)32(51)43-27(30(38)50)20-23-8-3-1-4-9-23/h1,3-4,8-9,13-18,24,26-28H,2,5-7,10-12,19-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077741
PNG
(5-[(E)-3-(2-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccccc2Cl)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46ClN11O5/c37-25-15-8-7-14-24(25)17-18-29(49)45-36-46-31(47-48-36)34(53)44-28(21-23-12-5-2-6-13-23)33(52)42-26(16-9-19-41-35(39)40)32(51)43-27(30(38)50)20-22-10-3-1-4-11-22/h1,3-4,7-8,10-11,14-15,17-18,23,26-28H,2,5-6,9,12-13,16,19-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077751
PNG
(5-[(E)-3-(2-Nitro-phenyl)-acryloylamino]-1H-[1,2,4...)
Show SMILES NC([NH-])=[NH+]CCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccccc2[N+]([O-])=O)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46N12O7/c37-30(50)26(20-22-10-3-1-4-11-22)42-32(51)25(15-9-19-40-35(38)39)41-33(52)27(21-23-12-5-2-6-13-23)43-34(53)31-45-36(47-46-31)44-29(49)18-17-24-14-7-8-16-28(24)48(54)55/h1,3-4,7-8,10-11,14,16-18,23,25-27H,2,5-6,9,12-13,15,19-21H2,(H11,37,38,39,40,41,42,43,44,45,46,47,49,50,51,52,53)/t25-,26-,27-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077747
PNG
(4-Oxo-4H-chromene-2-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(=O)c2ccccc2o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H43N7O6/c35-30(43)25(18-21-10-3-1-4-11-21)40-31(44)24(15-9-17-38-34(36)37)39-32(45)26(19-22-12-5-2-6-13-22)41-33(46)29-20-27(42)23-14-7-8-16-28(23)47-29/h1,3-4,7-8,10-11,14,16,20,22,24-26H,2,5-6,9,12-13,15,17-19H2,(H2,35,43)(H,39,45)(H,40,44)(H,41,46)(H4,36,37,38)/t24-,25-,26-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077726
PNG
(5-Bromo-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cncc(Br)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H41BrN8O4/c31-22-16-21(17-35-18-22)27(41)39-25(15-20-10-5-2-6-11-20)29(43)37-23(12-7-13-36-30(33)34)28(42)38-24(26(32)40)14-19-8-3-1-4-9-19/h1,3-4,8-9,16-18,20,23-25H,2,5-7,10-15H2,(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,36)/t23-,24-,25-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077748
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H41N11O4/c28-21(39)19(14-16-8-3-1-4-9-16)34-23(40)18(12-7-13-32-26(29)30)33-24(41)20(15-17-10-5-2-6-11-17)35-25(42)22-36-27(31)38-37-22/h1,3-4,8-9,17-20H,2,5-7,10-15H2,(H2,28,39)(H,33,41)(H,34,40)(H,35,42)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077764
PNG
(3-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccc(N)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C31H44N8O4/c32-23-14-7-13-22(19-23)28(41)39-26(18-21-11-5-2-6-12-21)30(43)37-24(15-8-16-36-31(34)35)29(42)38-25(27(33)40)17-20-9-3-1-4-10-20/h1,3-4,7,9-10,13-14,19,21,24-26H,2,5-6,8,11-12,15-18,32H2,(H2,33,40)(H,37,43)(H,38,42)(H,39,41)(H4,34,35,36)/t24-,25-,26-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077746
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O
Show InChI InChI=1S/C27H47N11O4/c28-21(39)19(14-16-8-3-1-4-9-16)34-23(40)18(12-7-13-32-26(29)30)33-24(41)20(15-17-10-5-2-6-11-17)35-25(42)22-36-27(31)38-37-22/h16-20H,1-15H2,(H2,28,39)(H,33,41)(H,34,40)(H,35,42)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077750
PNG
(6-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(N)nc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H43N9O4/c31-25-14-13-21(18-36-25)27(41)39-24(17-20-10-5-2-6-11-20)29(43)37-22(12-7-15-35-30(33)34)28(42)38-23(26(32)40)16-19-8-3-1-4-9-19/h1,3-4,8-9,13-14,18,20,22-24H,2,5-7,10-12,15-17H2,(H2,31,36)(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,35)/t22-,23-,24-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077744
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H35N11O4/c28-21(39)19(14-16-8-3-1-4-9-16)34-23(40)18(12-7-13-32-26(29)30)33-24(41)20(15-17-10-5-2-6-11-17)35-25(42)22-36-27(31)38-37-22/h1-6,8-11,18-20H,7,12-15H2,(H2,28,39)(H,33,41)(H,34,40)(H,35,42)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077749
PNG
(5-((Z)-2-Fluoro-3-phenyl-acryloylamino)-1H-[1,2,4]...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C(F)=Cc2ccccc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46FN11O5/c37-25(19-22-11-4-1-5-12-22)31(50)46-36-45-30(47-48-36)34(53)44-28(21-24-15-8-3-9-16-24)33(52)42-26(17-10-18-41-35(39)40)32(51)43-27(29(38)49)20-23-13-6-2-7-14-23/h1-2,4-7,11-14,19,24,26-28H,3,8-10,15-18,20-21H2,(H2,38,49)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,50)/t26-,27-,28-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077733
PNG
(Benzo[b]thiophene-2-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N7O4S/c34-29(41)25(18-21-10-3-1-4-11-21)39-30(42)24(15-9-17-37-33(35)36)38-31(43)26(19-22-12-5-2-6-13-22)40-32(44)28-20-23-14-7-8-16-27(23)45-28/h1,3-4,7-8,10-11,14,16,20,22,24-26H,2,5-6,9,12-13,15,17-19H2,(H2,34,41)(H,38,43)(H,39,42)(H,40,44)(H4,35,36,37)/t24-,25-,26-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077742
PNG
(2-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccnc1N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H43N9O4/c31-25-21(13-7-15-35-25)27(41)39-24(18-20-11-5-2-6-12-20)29(43)37-22(14-8-16-36-30(33)34)28(42)38-23(26(32)40)17-19-9-3-1-4-10-19/h1,3-4,7,9-10,13,15,20,22-24H,2,5-6,8,11-12,14,16-18H2,(H2,31,35)(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,36)/t22-,23-,24-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077736
PNG
(CHEMBL33945 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-p...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(Cl)nc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H41ClN8O4/c31-25-14-13-21(18-36-25)27(41)39-24(17-20-10-5-2-6-11-20)29(43)37-22(12-7-15-35-30(33)34)28(42)38-23(26(32)40)16-19-8-3-1-4-9-19/h1,3-4,8-9,13-14,18,20,22-24H,2,5-7,10-12,15-17H2,(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,35)/t22-,23-,24-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077728
PNG
(Biphenylene-2-carboxylic acid {(S)-1-[(S)-1-((S)-1...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc2-c3ccccc3-c2c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H45N7O4/c38-33(45)31(20-23-10-3-1-4-11-23)43-35(47)30(16-9-19-41-37(39)40)42-36(48)32(21-24-12-5-2-6-13-24)44-34(46)25-17-18-28-26-14-7-8-15-27(26)29(28)22-25/h1,3-4,7-8,10-11,14-15,17-18,22,24,30-32H,2,5-6,9,12-13,16,19-21H2,(H2,38,45)(H,42,48)(H,43,47)(H,44,46)(H4,39,40,41)/t30-,31-,32-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077753
PNG
(CHEMBL287270 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cnc(Cl)c(Cl)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H40Cl2N8O4/c31-21-16-20(17-37-25(21)32)27(42)40-24(15-19-10-5-2-6-11-19)29(44)38-22(12-7-13-36-30(34)35)28(43)39-23(26(33)41)14-18-8-3-1-4-9-18/h1,3-4,8-9,16-17,19,22-24H,2,5-7,10-15H2,(H2,33,41)(H,38,44)(H,39,43)(H,40,42)(H4,34,35,36)/t22-,23-,24-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077737
PNG
(4-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(N)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C31H44N8O4/c32-23-15-13-22(14-16-23)28(41)39-26(19-21-10-5-2-6-11-21)30(43)37-24(12-7-17-36-31(34)35)29(42)38-25(27(33)40)18-20-8-3-1-4-9-20/h1,3-4,8-9,13-16,21,24-26H,2,5-7,10-12,17-19,32H2,(H2,33,40)(H,37,43)(H,38,42)(H,39,41)(H4,34,35,36)/t24-,25-,26-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077762
PNG
(Benzofuran-2-carboxylic acid {(S)-1-[(S)-1-((S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N7O5/c34-29(41)25(18-21-10-3-1-4-11-21)39-30(42)24(15-9-17-37-33(35)36)38-31(43)26(19-22-12-5-2-6-13-22)40-32(44)28-20-23-14-7-8-16-27(23)45-28/h1,3-4,7-8,10-11,14,16,20,22,24-26H,2,5-6,9,12-13,15,17-19H2,(H2,34,41)(H,38,43)(H,39,42)(H,40,44)(H4,35,36,37)/t24-,25-,26-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077743
PNG
(CHEMBL33532 | Quinoxaline-2-carboxylic acid {(S)-1...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N9O4/c34-29(43)26(18-21-10-3-1-4-11-21)41-30(44)25(16-9-17-37-33(35)36)40-31(45)27(19-22-12-5-2-6-13-22)42-32(46)28-20-38-23-14-7-8-15-24(23)39-28/h1,3-4,7-8,10-11,14-15,20,22,25-27H,2,5-6,9,12-13,16-19H2,(H2,34,43)(H,40,45)(H,41,44)(H,42,46)(H4,35,36,37)/t25-,26-,27-/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077758
PNG
(5-((E)-2,3-Diphenyl-acryloylamino)-1H-[1,2,4]triaz...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C(=Cc2ccccc2)c2ccccc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H51N11O5/c43-35(54)33(25-28-16-7-2-8-17-28)48-38(56)32(22-13-23-46-41(44)45)47-39(57)34(26-29-18-9-3-10-19-29)49-40(58)36-50-42(53-52-36)51-37(55)31(30-20-11-4-12-21-30)24-27-14-5-1-6-15-27/h1-2,4-8,11-12,14-17,20-21,24,29,32-34H,3,9-10,13,18-19,22-23,25-26H2,(H2,43,54)(H,47,57)(H,48,56)(H,49,58)(H4,44,45,46)(H2,50,51,52,53,55)/t32-,33-,34-/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077734
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1cccs1)C(N)=O
Show InChI InChI=1S/C25H39N11O4S/c26-19(37)17(13-15-8-5-11-41-15)32-21(38)16(9-4-10-30-24(27)28)31-22(39)18(12-14-6-2-1-3-7-14)33-23(40)20-34-25(29)36-35-20/h5,8,11,14,16-18H,1-4,6-7,9-10,12-13H2,(H2,26,37)(H,31,39)(H,32,38)(H,33,40)(H4,27,28,30)(H3,29,34,35,36)/t16-,17-,18-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077771
PNG
(5-[(E)-3-(4-Methoxy-phenyl)-acryloylamino]-1H-[1,2...)
Show SMILES COc1ccc(C=CC(=O)Nc2nnc([nH]2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C37H49N11O6/c1-54-26-17-14-23(15-18-26)16-19-30(49)45-37-46-32(47-48-37)35(53)44-29(22-25-11-6-3-7-12-25)34(52)42-27(13-8-20-41-36(39)40)33(51)43-28(31(38)50)21-24-9-4-2-5-10-24/h2,4-5,9-10,14-19,25,27-29H,3,6-8,11-13,20-22H2,1H3,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t27-,28-,29-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077722
PNG
(1H-Benzoimidazole-5-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc2nc[nH]c2c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H37N9O4/c33-28(42)26(16-20-8-3-1-4-9-20)40-30(44)24(12-7-15-36-32(34)35)39-31(45)27(17-21-10-5-2-6-11-21)41-29(43)22-13-14-23-25(18-22)38-19-37-23/h1-6,8-11,13-14,18-19,24,26-27H,7,12,15-17H2,(H2,33,42)(H,37,38)(H,39,45)(H,40,44)(H,41,43)(H4,34,35,36)/t24-,26-,27-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077752
PNG
(5-((E)-2-Methyl-3-phenyl-acryloylamino)-1H-[1,2,4]...)
Show SMILES CC(=Cc1ccccc1)C(=O)Nc1nnc([nH]1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H49N11O5/c1-23(20-24-12-5-2-6-13-24)32(50)46-37-45-31(47-48-37)35(53)44-29(22-26-16-9-4-10-17-26)34(52)42-27(18-11-19-41-36(39)40)33(51)43-28(30(38)49)21-25-14-7-3-8-15-25/h2-3,5-8,12-15,20,26-29H,4,9-11,16-19,21-22H2,1H3,(H2,38,49)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,50)/t27-,28-,29-/m0/s1
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n/an/a 4.20E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077729
PNG
(CHEMBL33394 | Pyridine-2-carboxylic acid {(S)-1-[(...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H42N8O4/c31-26(39)24(18-20-10-3-1-4-11-20)37-28(41)23(15-9-17-35-30(32)33)36-29(42)25(19-21-12-5-2-6-13-21)38-27(40)22-14-7-8-16-34-22/h1,3-4,7-8,10-11,14,16,21,23-25H,2,5-6,9,12-13,15,17-19H2,(H2,31,39)(H,36,42)(H,37,41)(H,38,40)(H4,32,33,35)/t23-,24-,25-/m0/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077763
PNG
(5-((E)-3-Thiophen-2-yl-acryloylamino)-1H-[1,2,4]tr...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccs2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H45N11O5S/c35-28(47)25(19-21-9-3-1-4-10-21)40-30(48)24(14-7-17-38-33(36)37)39-31(49)26(20-22-11-5-2-6-12-22)41-32(50)29-43-34(45-44-29)42-27(46)16-15-23-13-8-18-51-23/h1,3-4,8-10,13,15-16,18,22,24-26H,2,5-7,11-12,14,17,19-20H2,(H2,35,47)(H,39,49)(H,40,48)(H,41,50)(H4,36,37,38)(H2,42,43,44,45,46)/t24-,25-,26-/m0/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077765
PNG
((S)-2-{(S)-3-Cyclohexyl-2-[(E)-(3-phenyl-acryloyl)...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)C=Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H45N7O4/c34-30(42)27(21-24-13-6-2-7-14-24)40-31(43)26(17-10-20-37-33(35)36)39-32(44)28(22-25-15-8-3-9-16-25)38-29(41)19-18-23-11-4-1-5-12-23/h1-2,4-7,11-14,18-19,25-28H,3,8-10,15-17,20-22H2,(H2,34,42)(H,38,41)(H,39,44)(H,40,43)(H4,35,36,37)/t26-,27-,28-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077755
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H41N9O4/c28-14-8-7-13-19(24(38)32-20(22(29)37)15-17-9-3-1-4-10-17)31-25(39)21(16-18-11-5-2-6-12-18)33-26(40)23-34-27(30)36-35-23/h1,3-4,9-10,18-21H,2,5-8,11-16,28H2,(H2,29,37)(H,31,39)(H,32,38)(H,33,40)(H3,30,34,35,36)/t19-,20-,21-/m0/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077754
PNG
((S)-2-[(S)-3-Cyclohexyl-2-((E)-3-pyridin-3-yl-acry...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)C=Cc1cccnc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H44N8O4/c33-29(42)26(19-22-9-3-1-4-10-22)40-30(43)25(14-8-18-37-32(34)35)39-31(44)27(20-23-11-5-2-6-12-23)38-28(41)16-15-24-13-7-17-36-21-24/h1,3-4,7,9-10,13,15-17,21,23,25-27H,2,5-6,8,11-12,14,18-20H2,(H2,33,42)(H,38,41)(H,39,44)(H,40,43)(H4,34,35,37)/t25-,26-,27-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077718
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C27H41N11O5/c28-21(40)19(13-16-8-10-17(39)11-9-16)34-23(41)18(7-4-12-32-26(29)30)33-24(42)20(14-15-5-2-1-3-6-15)35-25(43)22-36-27(31)38-37-22/h8-11,15,18-20,39H,1-7,12-14H2,(H2,28,40)(H,33,42)(H,34,41)(H,35,43)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077724
PNG
(5-[(E)-(3-Phenyl-acryloyl)amino]-1H-[1,2,4]triazol...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccccc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H47N11O5/c37-30(49)27(21-24-13-6-2-7-14-24)42-32(50)26(17-10-20-40-35(38)39)41-33(51)28(22-25-15-8-3-9-16-25)43-34(52)31-45-36(47-46-31)44-29(48)19-18-23-11-4-1-5-12-23/h1-2,4-7,11-14,18-19,25-28H,3,8-10,15-17,20-22H2,(H2,37,49)(H,41,51)(H,42,50)(H,43,52)(H4,38,39,40)(H2,44,45,46,47,48)/t26-,27-,28-/m0/s1
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n/an/a 6.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077727
PNG
(CHEMBL33781 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-p...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccncc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H42N8O4/c31-26(39)24(18-20-8-3-1-4-9-20)37-28(41)23(12-7-15-35-30(32)33)36-29(42)25(19-21-10-5-2-6-11-21)38-27(40)22-13-16-34-17-14-22/h1,3-4,8-9,13-14,16-17,21,23-25H,2,5-7,10-12,15,18-19H2,(H2,31,39)(H,36,42)(H,37,41)(H,38,40)(H4,32,33,35)/t23-,24-,25-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077720
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@H](C(N)=O)c1ccccc1
Show InChI InChI=1S/C26H39N11O4/c27-20(38)19(16-10-5-2-6-11-16)34-22(39)17(12-7-13-31-25(28)29)32-23(40)18(14-15-8-3-1-4-9-15)33-24(41)21-35-26(30)37-36-21/h2,5-6,10-11,15,17-19H,1,3-4,7-9,12-14H2,(H2,27,38)(H,32,40)(H,33,41)(H,34,39)(H4,28,29,31)(H3,30,35,36,37)/t17-,18-,19-/m0/s1
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The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077760
PNG
(CHEMBL281443 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccnc1Cl)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H41ClN8O4/c31-25-21(13-7-15-35-25)27(41)39-24(18-20-11-5-2-6-12-20)29(43)37-22(14-8-16-36-30(33)34)28(42)38-23(26(32)40)17-19-9-3-1-4-10-19/h1,3-4,7,9-10,13,15,20,22-24H,2,5-6,8,11-12,14,16-18H2,(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,36)/t22-,23-,24-/m0/s1
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n/an/a 7.60E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077740
PNG
(5-[(E)-3-(3-Nitro-phenyl)-acryloylamino]-1H-[1,2,4...)
Show SMILES NC([NH-])=[NH+]CCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccc(c2)[N+]([O-])=O)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46N12O7/c37-30(50)27(20-22-9-3-1-4-10-22)42-32(51)26(15-8-18-40-35(38)39)41-33(52)28(21-23-11-5-2-6-12-23)43-34(53)31-45-36(47-46-31)44-29(49)17-16-24-13-7-14-25(19-24)48(54)55/h1,3-4,7,9-10,13-14,16-17,19,23,26-28H,2,5-6,8,11-12,15,18,20-21H2,(H11,37,38,39,40,41,42,43,44,45,46,47,49,50,51,52,53)/t26-,27-,28-/m0/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077756
PNG
(3-Amino-pyrazine-2-carboxylic acid {(S)-1-[(S)-1-(...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nccnc1N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H42N10O4/c30-24-23(34-14-15-35-24)28(43)39-22(17-19-10-5-2-6-11-19)27(42)37-20(12-7-13-36-29(32)33)26(41)38-21(25(31)40)16-18-8-3-1-4-9-18/h1,3-4,8-9,14-15,19-22H,2,5-7,10-13,16-17H2,(H2,30,35)(H2,31,40)(H,37,42)(H,38,41)(H,39,43)(H4,32,33,36)/t20-,21-,22-/m0/s1
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n/an/a 8.50E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077767
PNG
((S)-2-[(S)-2-(3-Amino-propionylamino)-3-cyclohexyl...)
Show SMILES NCCC(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H44N8O4/c28-14-13-23(36)33-22(17-19-10-5-2-6-11-19)26(39)34-20(12-7-15-32-27(30)31)25(38)35-21(24(29)37)16-18-8-3-1-4-9-18/h1,3-4,8-9,19-22H,2,5-7,10-17,28H2,(H2,29,37)(H,33,36)(H,34,39)(H,35,38)(H4,30,31,32)/t20-,21-,22-/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077732
PNG
(CHEMBL285018 | [1,2,3]Thiadiazole-4-carboxylic aci...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1csnn1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H39N9O4S/c28-23(37)20(14-17-8-3-1-4-9-17)33-24(38)19(12-7-13-31-27(29)30)32-25(39)21(15-18-10-5-2-6-11-18)34-26(40)22-16-41-36-35-22/h1,3-4,8-9,16,18-21H,2,5-7,10-15H2,(H2,28,37)(H,32,39)(H,33,38)(H,34,40)(H4,29,30,31)/t19-,20-,21-/m0/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077731
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](CCc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H43N11O4/c29-22(40)19(14-13-17-8-3-1-4-9-17)34-24(41)20(12-7-15-33-27(30)31)35-25(42)21(16-18-10-5-2-6-11-18)36-26(43)23-37-28(32)39-38-23/h1,3-4,8-9,18-21H,2,5-7,10-16H2,(H2,29,40)(H,34,41)(H,35,42)(H,36,43)(H4,30,31,33)(H3,32,37,38,39)/t19-,20-,21-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077735
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(N)=O
Show InChI InChI=1S/C21H37N11O4/c1-11(15(22)33)27-17(34)13(8-5-9-26-20(23)24)28-18(35)14(10-12-6-3-2-4-7-12)29-19(36)16-30-21(25)32-31-16/h11-14H,2-10H2,1H3,(H2,22,33)(H,27,34)(H,28,35)(H,29,36)(H4,23,24,26)(H3,25,30,31,32)/t11-,13-,14-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077745
PNG
(1H-Pyrrole-2-carboxylic acid {(S)-1-[(S)-1-((S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H42N8O4/c30-25(38)23(17-19-9-3-1-4-10-19)36-27(40)22(14-8-16-34-29(31)32)35-28(41)24(18-20-11-5-2-6-12-20)37-26(39)21-13-7-15-33-21/h1,3-4,7,9-10,13,15,20,22-24,33H,2,5-6,8,11-12,14,16-18H2,(H2,30,38)(H,35,41)(H,36,40)(H,37,39)(H4,31,32,34)/t22-,23-,24-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077769
PNG
(Biphenyl-4-carboxylic acid {(S)-1-[(S)-1-((S)-1-ca...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H47N7O4/c38-33(45)31(23-25-11-4-1-5-12-25)43-35(47)30(17-10-22-41-37(39)40)42-36(48)32(24-26-13-6-2-7-14-26)44-34(46)29-20-18-28(19-21-29)27-15-8-3-9-16-27/h1,3-5,8-9,11-12,15-16,18-21,26,30-32H,2,6-7,10,13-14,17,22-24H2,(H2,38,45)(H,42,48)(H,43,47)(H,44,46)(H4,39,40,41)/t30-,31-,32-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077759
PNG
(5-[(E)-3-(3-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccc(Cl)c2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46ClN11O5/c37-25-14-7-13-24(19-25)16-17-29(49)45-36-46-31(47-48-36)34(53)44-28(21-23-11-5-2-6-12-23)33(52)42-26(15-8-18-41-35(39)40)32(51)43-27(30(38)50)20-22-9-3-1-4-10-22/h1,3-4,7,9-10,13-14,16-17,19,23,26-28H,2,5-6,8,11-12,15,18,20-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077738
PNG
(5-((E)-3-Naphthalen-1-yl-acryloylamino)-1H-[1,2,4]...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccc3ccccc23)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C40H49N11O5/c41-34(53)31(23-25-11-3-1-4-12-25)46-36(54)30(19-10-22-44-39(42)43)45-37(55)32(24-26-13-5-2-6-14-26)47-38(56)35-49-40(51-50-35)48-33(52)21-20-28-17-9-16-27-15-7-8-18-29(27)28/h1,3-4,7-9,11-12,15-18,20-21,26,30-32H,2,5-6,10,13-14,19,22-24H2,(H2,41,53)(H,45,55)(H,46,54)(H,47,56)(H4,42,43,44)(H2,48,49,50,51,52)/t30-,31-,32-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077719
PNG
(Benzo[1,4]dioxine-2-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)C1=COc2ccccc2O1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N7O6/c34-29(41)24(18-21-10-3-1-4-11-21)39-30(42)23(14-9-17-37-33(35)36)38-31(43)25(19-22-12-5-2-6-13-22)40-32(44)28-20-45-26-15-7-8-16-27(26)46-28/h1,3-4,7-8,10-11,15-16,20,22-25H,2,5-6,9,12-14,17-19H2,(H2,34,41)(H,38,43)(H,39,42)(H,40,44)(H4,35,36,37)/t23-,24-,25-/m0/s1
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The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077766
PNG
(2-Oxo-2,3-dihydro-pyridine-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc[nH]c1=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H42N8O5/c31-25(39)23(17-19-9-3-1-4-10-19)37-28(42)22(14-8-16-35-30(32)33)36-29(43)24(18-20-11-5-2-6-12-20)38-27(41)21-13-7-15-34-26(21)40/h1,3-4,7,9-10,13,15,20,22-24H,2,5-6,8,11-12,14,16-18H2,(H2,31,39)(H,34,40)(H,36,43)(H,37,42)(H,38,41)(H4,32,33,35)/t22-,23-,24-/m0/s1
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The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077768
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES C[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C24H34N8O4/c1-14(21(34)28-17(19(25)33)12-15-8-4-2-5-9-15)27-22(35)18(13-16-10-6-3-7-11-16)29-23(36)20-30-24(26)32-31-20/h2,4-5,8-9,14,16-18H,3,6-7,10-13H2,1H3,(H2,25,33)(H,27,35)(H,28,34)(H,29,36)(H3,26,30,31,32)/t14-,17-,18-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077772
PNG
(CHEMBL285186 | Furan-3-carboxylic acid {(S)-1-[(S)...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccoc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H41N7O5/c30-25(37)23(16-19-8-3-1-4-9-19)35-27(39)22(12-7-14-33-29(31)32)34-28(40)24(17-20-10-5-2-6-11-20)36-26(38)21-13-15-41-18-21/h1,3-4,8-9,13,15,18,20,22-24H,2,5-7,10-12,14,16-17H2,(H2,30,37)(H,34,40)(H,35,39)(H,36,38)(H4,31,32,33)/t22-,23-,24-/m0/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077739
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C24H39N13O4/c25-18(38)16(10-14-11-29-12-31-14)33-20(39)15(7-4-8-30-23(26)27)32-21(40)17(9-13-5-2-1-3-6-13)34-22(41)19-35-24(28)37-36-19/h11-13,15-17H,1-10H2,(H2,25,38)(H,29,31)(H,32,40)(H,33,39)(H,34,41)(H4,26,27,30)(H3,28,35,36,37)/t15-,16-,17-/m0/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077721
PNG
(5-[(E)-3-(4-Trifluoromethyl-phenyl)-acryloylamino]...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(cc2)C(F)(F)F)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H46F3N11O5/c38-37(39,40)25-16-13-22(14-17-25)15-18-29(52)48-36-49-31(50-51-36)34(56)47-28(21-24-10-5-2-6-11-24)33(55)45-26(12-7-19-44-35(42)43)32(54)46-27(30(41)53)20-23-8-3-1-4-9-23/h1,3-4,8-9,13-18,24,26-28H,2,5-7,10-12,19-21H2,(H2,41,53)(H,45,55)(H,46,54)(H,47,56)(H4,42,43,44)(H2,48,49,50,51,52)/t26-,27-,28-/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077761
PNG
(5-[(E)-3-(4-Cyano-phenyl)-acryloylamino]-1H-[1,2,4...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(cc2)C#N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H46N12O5/c38-22-26-15-13-23(14-16-26)17-18-30(50)46-37-47-32(48-49-37)35(54)45-29(21-25-10-5-2-6-11-25)34(53)43-27(12-7-19-42-36(40)41)33(52)44-28(31(39)51)20-24-8-3-1-4-9-24/h1,3-4,8-9,13-18,25,27-29H,2,5-7,10-12,19-21H2,(H2,39,51)(H,43,53)(H,44,52)(H,45,54)(H4,40,41,42)(H2,46,47,48,49,50)/t27-,28-,29-/m0/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077773
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES C[C@H](NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C21H31N11O4/c1-11(27-19(36)16-30-21(25)32-31-16)17(34)28-13(8-5-9-26-20(23)24)18(35)29-14(15(22)33)10-12-6-3-2-4-7-12/h2-4,6-7,11,13-14H,5,8-10H2,1H3,(H2,22,33)(H,27,36)(H,28,34)(H,29,35)(H4,23,24,26)(H3,25,30,31,32)/t11-,13-,14-/m0/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077757
PNG
(1H-Indole-2-carboxylic acid {(S)-1-[(S)-1-((S)-1-c...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H44N8O4/c34-29(42)26(18-21-10-3-1-4-11-21)40-30(43)25(16-9-17-37-33(35)36)39-31(44)27(19-22-12-5-2-6-13-22)41-32(45)28-20-23-14-7-8-15-24(23)38-28/h1,3-4,7-8,10-11,14-15,20,22,25-27,38H,2,5-6,9,12-13,16-19H2,(H2,34,42)(H,39,44)(H,40,43)(H,41,45)(H4,35,36,37)/t25-,26-,27-/m0/s1
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n/an/a 5.60E+4n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077770
PNG
(5-((E)-3-1H-Indol-3-yl-acryloylamino)-1H-[1,2,4]tr...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2c[nH]c3ccccc23)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C38H48N12O5/c39-32(52)29(20-23-10-3-1-4-11-23)45-34(53)28(16-9-19-42-37(40)41)44-35(54)30(21-24-12-5-2-6-13-24)46-36(55)33-48-38(50-49-33)47-31(51)18-17-25-22-43-27-15-8-7-14-26(25)27/h1,3-4,7-8,10-11,14-15,17-18,22,24,28-30,43H,2,5-6,9,12-13,16,19-21H2,(H2,39,52)(H,44,54)(H,45,53)(H,46,55)(H4,40,41,42)(H2,47,48,49,50,51)/t28-,29-,30-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077741
PNG
(5-[(E)-3-(2-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccccc2Cl)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46ClN11O5/c37-25-15-8-7-14-24(25)17-18-29(49)45-36-46-31(47-48-36)34(53)44-28(21-23-12-5-2-6-13-23)33(52)42-26(16-9-19-41-35(39)40)32(51)43-27(30(38)50)20-22-10-3-1-4-11-22/h1,3-4,7-8,10-11,14-15,17-18,23,26-28H,2,5-6,9,12-13,16,19-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077743
PNG
(CHEMBL33532 | Quinoxaline-2-carboxylic acid {(S)-1...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N9O4/c34-29(43)26(18-21-10-3-1-4-11-21)41-30(44)25(16-9-17-37-33(35)36)40-31(45)27(19-22-12-5-2-6-13-22)42-32(46)28-20-38-23-14-7-8-15-24(23)39-28/h1,3-4,7-8,10-11,14-15,20,22,25-27H,2,5-6,9,12-13,16-19H2,(H2,34,43)(H,40,45)(H,41,44)(H,42,46)(H4,35,36,37)/t25-,26-,27-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077724
PNG
(5-[(E)-(3-Phenyl-acryloyl)amino]-1H-[1,2,4]triazol...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccccc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H47N11O5/c37-30(49)27(21-24-13-6-2-7-14-24)42-32(50)26(17-10-20-40-35(38)39)41-33(51)28(22-25-15-8-3-9-16-25)43-34(52)31-45-36(47-46-31)44-29(48)19-18-23-11-4-1-5-12-23/h1-2,4-7,11-14,18-19,25-28H,3,8-10,15-17,20-22H2,(H2,37,49)(H,41,51)(H,42,50)(H,43,52)(H4,38,39,40)(H2,44,45,46,47,48)/t26-,27-,28-/m0/s1
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n/an/an/an/a 2.10E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077759
PNG
(5-[(E)-3-(3-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccc(Cl)c2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46ClN11O5/c37-25-14-7-13-24(19-25)16-17-29(49)45-36-46-31(47-48-36)34(53)44-28(21-23-11-5-2-6-12-23)33(52)42-26(15-8-18-41-35(39)40)32(51)43-27(30(38)50)20-22-9-3-1-4-10-22/h1,3-4,7,9-10,13-14,16-17,19,23,26-28H,2,5-6,8,11-12,15,18,20-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077725
PNG
(5-[(E)-3-(4-Fluoro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(F)cc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46FN11O5/c37-25-16-13-22(14-17-25)15-18-29(49)45-36-46-31(47-48-36)34(53)44-28(21-24-10-5-2-6-11-24)33(52)42-26(12-7-19-41-35(39)40)32(51)43-27(30(38)50)20-23-8-3-1-4-9-23/h1,3-4,8-9,13-18,24,26-28H,2,5-7,10-12,19-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/an/an/a 7.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077763
PNG
(5-((E)-3-Thiophen-2-yl-acryloylamino)-1H-[1,2,4]tr...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccs2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H45N11O5S/c35-28(47)25(19-21-9-3-1-4-10-21)40-30(48)24(14-7-17-38-33(36)37)39-31(49)26(20-22-11-5-2-6-12-22)41-32(50)29-43-34(45-44-29)42-27(46)16-15-23-13-8-18-51-23/h1,3-4,8-10,13,15-16,18,22,24-26H,2,5-7,11-12,14,17,19-20H2,(H2,35,47)(H,39,49)(H,40,48)(H,41,50)(H4,36,37,38)(H2,42,43,44,45,46)/t24-,25-,26-/m0/s1
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n/an/an/an/a 2.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077734
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1cccs1)C(N)=O
Show InChI InChI=1S/C25H39N11O4S/c26-19(37)17(13-15-8-5-11-41-15)32-21(38)16(9-4-10-30-24(27)28)31-22(39)18(12-14-6-2-1-3-7-14)33-23(40)20-34-25(29)36-35-20/h5,8,11,14,16-18H,1-4,6-7,9-10,12-13H2,(H2,26,37)(H,31,39)(H,32,38)(H,33,40)(H4,27,28,30)(H3,29,34,35,36)/t16-,17-,18-/m0/s1
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n/an/an/an/a 1.05E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077723
PNG
(5-[(E)-3-(4-Chloro-phenyl)-acryloylamino]-1H-[1,2,...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(Cl)cc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46ClN11O5/c37-25-16-13-22(14-17-25)15-18-29(49)45-36-46-31(47-48-36)34(53)44-28(21-24-10-5-2-6-11-24)33(52)42-26(12-7-19-41-35(39)40)32(51)43-27(30(38)50)20-23-8-3-1-4-9-23/h1,3-4,8-9,13-18,24,26-28H,2,5-7,10-12,19-21H2,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t26-,27-,28-/m0/s1
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n/an/an/an/a 5.50E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077728
PNG
(Biphenylene-2-carboxylic acid {(S)-1-[(S)-1-((S)-1...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc2-c3ccccc3-c2c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H45N7O4/c38-33(45)31(20-23-10-3-1-4-11-23)43-35(47)30(16-9-19-41-37(39)40)42-36(48)32(21-24-12-5-2-6-13-24)44-34(46)25-17-18-28-26-14-7-8-15-27(26)29(28)22-25/h1,3-4,7-8,10-11,14-15,17-18,22,24,30-32H,2,5-6,9,12-13,16,19-21H2,(H2,38,45)(H,42,48)(H,43,47)(H,44,46)(H4,39,40,41)/t30-,31-,32-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077718
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C27H41N11O5/c28-21(40)19(13-16-8-10-17(39)11-9-16)34-23(41)18(7-4-12-32-26(29)30)33-24(42)20(14-15-5-2-1-3-6-15)35-25(43)22-36-27(31)38-37-22/h8-11,15,18-20,39H,1-7,12-14H2,(H2,28,40)(H,33,42)(H,34,41)(H,35,43)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/an/an/a 9.70E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077762
PNG
(Benzofuran-2-carboxylic acid {(S)-1-[(S)-1-((S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N7O5/c34-29(41)25(18-21-10-3-1-4-11-21)39-30(42)24(15-9-17-37-33(35)36)38-31(43)26(19-22-12-5-2-6-13-22)40-32(44)28-20-23-14-7-8-16-27(23)45-28/h1,3-4,7-8,10-11,14,16,20,22,24-26H,2,5-6,9,12-13,15,17-19H2,(H2,34,41)(H,38,43)(H,39,42)(H,40,44)(H4,35,36,37)/t24-,25-,26-/m0/s1
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n/an/an/an/a 1.25E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077738
PNG
(5-((E)-3-Naphthalen-1-yl-acryloylamino)-1H-[1,2,4]...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccc3ccccc23)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C40H49N11O5/c41-34(53)31(23-25-11-3-1-4-12-25)46-36(54)30(19-10-22-44-39(42)43)45-37(55)32(24-26-13-5-2-6-14-26)47-38(56)35-49-40(51-50-35)48-33(52)21-20-28-17-9-16-27-15-7-8-18-29(27)28/h1,3-4,7-9,11-12,15-18,20-21,26,30-32H,2,5-6,10,13-14,19,22-24H2,(H2,41,53)(H,45,55)(H,46,54)(H,47,56)(H4,42,43,44)(H2,48,49,50,51,52)/t30-,31-,32-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077752
PNG
(5-((E)-2-Methyl-3-phenyl-acryloylamino)-1H-[1,2,4]...)
Show SMILES CC(=Cc1ccccc1)C(=O)Nc1nnc([nH]1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H49N11O5/c1-23(20-24-12-5-2-6-13-24)32(50)46-37-45-31(47-48-37)35(53)44-29(22-26-16-9-4-10-17-26)34(52)42-27(18-11-19-41-36(39)40)33(51)43-28(30(38)49)21-25-14-7-3-8-15-25/h2-3,5-8,12-15,20,26-29H,4,9-11,16-19,21-22H2,1H3,(H2,38,49)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,50)/t27-,28-,29-/m0/s1
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n/an/an/an/a 760n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077736
PNG
(CHEMBL33945 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-p...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(Cl)nc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H41ClN8O4/c31-25-14-13-21(18-36-25)27(41)39-24(17-20-10-5-2-6-11-20)29(43)37-22(12-7-15-35-30(33)34)28(42)38-23(26(32)40)16-19-8-3-1-4-9-19/h1,3-4,8-9,13-14,18,20,22-24H,2,5-7,10-12,15-17H2,(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,35)/t22-,23-,24-/m0/s1
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n/an/an/an/a 4.60E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077730
PNG
(CHEMBL284498 | N-{(S)-1-[(S)-1-((S)-1-Carbamoyl-2-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H42N8O4/c31-26(39)24(17-20-9-3-1-4-10-20)37-28(41)23(14-8-16-35-30(32)33)36-29(42)25(18-21-11-5-2-6-12-21)38-27(40)22-13-7-15-34-19-22/h1,3-4,7,9-10,13,15,19,21,23-25H,2,5-6,8,11-12,14,16-18H2,(H2,31,39)(H,36,42)(H,37,41)(H,38,40)(H4,32,33,35)/t23-,24-,25-/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50031392
PNG
((S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-h...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C34H57N11O8/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40)/t21-,22-,23-,24-,25-,26-/m0/s1
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n/an/an/an/a 280n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077726
PNG
(5-Bromo-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cncc(Br)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H41BrN8O4/c31-22-16-21(17-35-18-22)27(41)39-25(15-20-10-5-2-6-11-20)29(43)37-23(12-7-13-36-30(33)34)28(42)38-24(26(32)40)14-19-8-3-1-4-9-19/h1,3-4,8-9,16-18,20,23-25H,2,5-7,10-15H2,(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,36)/t23-,24-,25-/m0/s1
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n/an/an/an/a 460n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077771
PNG
(5-[(E)-3-(4-Methoxy-phenyl)-acryloylamino]-1H-[1,2...)
Show SMILES COc1ccc(C=CC(=O)Nc2nnc([nH]2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C37H49N11O6/c1-54-26-17-14-23(15-18-26)16-19-30(49)45-37-46-32(47-48-37)35(53)44-29(22-25-11-6-3-7-12-25)34(52)42-27(13-8-20-41-36(39)40)33(51)43-28(31(38)50)21-24-9-4-2-5-10-24/h2,4-5,9-10,14-19,25,27-29H,3,6-8,11-13,20-22H2,1H3,(H2,38,50)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,49)/t27-,28-,29-/m0/s1
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n/an/an/an/a 5.60E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077744
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H35N11O4/c28-21(39)19(14-16-8-3-1-4-9-16)34-23(40)18(12-7-13-32-26(29)30)33-24(41)20(15-17-10-5-2-6-11-17)35-25(42)22-36-27(31)38-37-22/h1-6,8-11,18-20H,7,12-15H2,(H2,28,39)(H,33,41)(H,34,40)(H,35,42)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077722
PNG
(1H-Benzoimidazole-5-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc2nc[nH]c2c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H37N9O4/c33-28(42)26(16-20-8-3-1-4-9-20)40-30(44)24(12-7-15-36-32(34)35)39-31(45)27(17-21-10-5-2-6-11-21)41-29(43)22-13-14-23-25(18-22)38-19-37-23/h1-6,8-11,13-14,18-19,24,26-27H,7,12,15-17H2,(H2,33,42)(H,37,38)(H,39,45)(H,40,44)(H,41,43)(H4,34,35,36)/t24-,26-,27-/m0/s1
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n/an/an/an/a 4.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077761
PNG
(5-[(E)-3-(4-Cyano-phenyl)-acryloylamino]-1H-[1,2,4...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(cc2)C#N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H46N12O5/c38-22-26-15-13-23(14-16-26)17-18-30(50)46-37-47-32(48-49-37)35(54)45-29(21-25-10-5-2-6-11-25)34(53)43-27(12-7-19-42-36(40)41)33(52)44-28(31(39)51)20-24-8-3-1-4-9-24/h1,3-4,8-9,13-18,25,27-29H,2,5-7,10-12,19-21H2,(H2,39,51)(H,43,53)(H,44,52)(H,45,54)(H4,40,41,42)(H2,46,47,48,49,50)/t27-,28-,29-/m0/s1
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n/an/an/an/a 5.80E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077720
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid ((S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@H](C(N)=O)c1ccccc1
Show InChI InChI=1S/C26H39N11O4/c27-20(38)19(16-10-5-2-6-11-16)34-22(39)17(12-7-13-31-25(28)29)32-23(40)18(14-15-8-3-1-4-9-15)33-24(41)21-35-26(30)37-36-21/h2,5-6,10-11,15,17-19H,1,3-4,7-9,12-14H2,(H2,27,38)(H,32,40)(H,33,41)(H,34,39)(H4,28,29,31)(H3,30,35,36,37)/t17-,18-,19-/m0/s1
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n/an/an/an/a 3.10E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077732
PNG
(CHEMBL285018 | [1,2,3]Thiadiazole-4-carboxylic aci...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1csnn1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H39N9O4S/c28-23(37)20(14-17-8-3-1-4-9-17)33-24(38)19(12-7-13-31-27(29)30)32-25(39)21(15-18-10-5-2-6-11-18)34-26(40)22-16-41-36-35-22/h1,3-4,8-9,16,18-21H,2,5-7,10-15H2,(H2,28,37)(H,32,39)(H,33,38)(H,34,40)(H4,29,30,31)/t19-,20-,21-/m0/s1
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n/an/an/an/a 1.30E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077740
PNG
(5-[(E)-3-(3-Nitro-phenyl)-acryloylamino]-1H-[1,2,4...)
Show SMILES NC([NH-])=[NH+]CCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2cccc(c2)[N+]([O-])=O)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46N12O7/c37-30(50)27(20-22-9-3-1-4-10-22)42-32(51)26(15-8-18-40-35(38)39)41-33(52)28(21-23-11-5-2-6-12-23)43-34(53)31-45-36(47-46-31)44-29(49)17-16-24-13-7-14-25(19-24)48(54)55/h1,3-4,7,9-10,13-14,16-17,19,23,26-28H,2,5-6,8,11-12,15,18,20-21H2,(H11,37,38,39,40,41,42,43,44,45,46,47,49,50,51,52,53)/t26-,27-,28-/m0/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077748
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H41N11O4/c28-21(39)19(14-16-8-3-1-4-9-16)34-23(40)18(12-7-13-32-26(29)30)33-24(41)20(15-17-10-5-2-6-11-17)35-25(42)22-36-27(31)38-37-22/h1,3-4,8-9,17-20H,2,5-7,10-15H2,(H2,28,39)(H,33,41)(H,34,40)(H,35,42)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/an/an/a 760n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077758
PNG
(5-((E)-2,3-Diphenyl-acryloylamino)-1H-[1,2,4]triaz...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C(=Cc2ccccc2)c2ccccc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H51N11O5/c43-35(54)33(25-28-16-7-2-8-17-28)48-38(56)32(22-13-23-46-41(44)45)47-39(57)34(26-29-18-9-3-10-19-29)49-40(58)36-50-42(53-52-36)51-37(55)31(30-20-11-4-12-21-30)24-27-14-5-1-6-15-27/h1-2,4-8,11-12,14-17,20-21,24,29,32-34H,3,9-10,13,18-19,22-23,25-26H2,(H2,43,54)(H,47,57)(H,48,56)(H,49,58)(H4,44,45,46)(H2,50,51,52,53,55)/t32-,33-,34-/m0/s1
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n/an/an/an/a 2.80E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to Thrombin receptor 1 (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077747
PNG
(4-Oxo-4H-chromene-2-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(=O)c2ccccc2o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C34H43N7O6/c35-30(43)25(18-21-10-3-1-4-11-21)40-31(44)24(15-9-17-38-34(36)37)39-32(45)26(19-22-12-5-2-6-13-22)41-33(46)29-20-27(42)23-14-7-8-16-28(23)47-29/h1,3-4,7-8,10-11,14,16,20,22,24-26H,2,5-6,9,12-13,15,17-19H2,(H2,35,43)(H,39,45)(H,40,44)(H,41,46)(H4,36,37,38)/t24-,25-,26-/m0/s1
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n/an/an/an/a 510n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077742
PNG
(2-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccnc1N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H43N9O4/c31-25-21(13-7-15-35-25)27(41)39-24(18-20-11-5-2-6-12-20)29(43)37-22(14-8-16-36-30(33)34)28(42)38-23(26(32)40)17-19-9-3-1-4-10-19/h1,3-4,7,9-10,13,15,20,22-24H,2,5-6,8,11-12,14,16-18H2,(H2,31,35)(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,36)/t22-,23-,24-/m0/s1
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n/an/an/an/a 8.00E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077750
PNG
(6-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccc(N)nc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H43N9O4/c31-25-14-13-21(18-36-25)27(41)39-24(17-20-10-5-2-6-11-20)29(43)37-22(12-7-15-35-30(33)34)28(42)38-23(26(32)40)16-19-8-3-1-4-9-19/h1,3-4,8-9,13-14,18,20,22-24H,2,5-7,10-12,15-17H2,(H2,31,36)(H2,32,40)(H,37,43)(H,38,42)(H,39,41)(H4,33,34,35)/t22-,23-,24-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077756
PNG
(3-Amino-pyrazine-2-carboxylic acid {(S)-1-[(S)-1-(...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nccnc1N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H42N10O4/c30-24-23(34-14-15-35-24)28(43)39-22(17-19-10-5-2-6-11-19)27(42)37-20(12-7-13-36-29(32)33)26(41)38-21(25(31)40)16-18-8-3-1-4-9-18/h1,3-4,8-9,14-15,19-22H,2,5-7,10-13,16-17H2,(H2,30,35)(H2,31,40)(H,37,42)(H,38,41)(H,39,43)(H4,32,33,36)/t20-,21-,22-/m0/s1
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n/an/an/an/a 4.20E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077770
PNG
(5-((E)-3-1H-Indol-3-yl-acryloylamino)-1H-[1,2,4]tr...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2c[nH]c3ccccc23)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C38H48N12O5/c39-32(52)29(20-23-10-3-1-4-11-23)45-34(53)28(16-9-19-42-37(40)41)44-35(54)30(21-24-12-5-2-6-13-24)46-36(55)33-48-38(50-49-33)47-31(51)18-17-25-22-43-27-15-8-7-14-26(25)27/h1,3-4,7-8,10-11,14-15,17-18,22,24,28-30,43H,2,5-6,9,12-13,16,19-21H2,(H2,39,52)(H,44,54)(H,45,53)(H,46,55)(H4,40,41,42)(H2,47,48,49,50,51)/t28-,29-,30-/m0/s1
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n/an/an/an/a 1.40E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077754
PNG
((S)-2-[(S)-3-Cyclohexyl-2-((E)-3-pyridin-3-yl-acry...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)C=Cc1cccnc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C32H44N8O4/c33-29(42)26(19-22-9-3-1-4-10-22)40-30(43)25(14-8-18-37-32(34)35)39-31(44)27(20-23-11-5-2-6-12-23)38-28(41)16-15-24-13-7-17-36-21-24/h1,3-4,7,9-10,13,15-17,21,23,25-27H,2,5-6,8,11-12,14,18-20H2,(H2,33,42)(H,38,41)(H,39,44)(H,40,43)(H4,34,35,37)/t25-,26-,27-/m0/s1
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n/an/an/an/a 2.60E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077755
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C27H41N9O4/c28-14-8-7-13-19(24(38)32-20(22(29)37)15-17-9-3-1-4-10-17)31-25(39)21(16-18-11-5-2-6-12-18)33-26(40)23-34-27(30)36-35-23/h1,3-4,9-10,18-21H,2,5-8,11-16,28H2,(H2,29,37)(H,31,39)(H,32,38)(H,33,40)(H3,30,34,35,36)/t19-,20-,21-/m0/s1
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n/an/an/an/a 3.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077721
PNG
(5-[(E)-3-(4-Trifluoromethyl-phenyl)-acryloylamino]...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccc(cc2)C(F)(F)F)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H46F3N11O5/c38-37(39,40)25-16-13-22(14-17-25)15-18-29(52)48-36-49-31(50-51-36)34(56)47-28(21-24-10-5-2-6-11-24)33(55)45-26(12-7-19-44-35(42)43)32(54)46-27(30(41)53)20-23-8-3-1-4-9-23/h1,3-4,8-9,13-18,24,26-28H,2,5-7,10-12,19-21H2,(H2,41,53)(H,45,55)(H,46,54)(H,47,56)(H4,42,43,44)(H2,48,49,50,51,52)/t26-,27-,28-/m0/s1
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n/an/an/an/a 5.00E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077729
PNG
(CHEMBL33394 | Pyridine-2-carboxylic acid {(S)-1-[(...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H42N8O4/c31-26(39)24(18-20-10-3-1-4-11-20)37-28(41)23(15-9-17-35-30(32)33)36-29(42)25(19-21-12-5-2-6-13-21)38-27(40)22-14-7-8-16-34-22/h1,3-4,7-8,10-11,14,16,21,23-25H,2,5-6,9,12-13,15,17-19H2,(H2,31,39)(H,36,42)(H,37,41)(H,38,40)(H4,32,33,35)/t23-,24-,25-/m0/s1
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n/an/an/an/a 1.40E+4n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077751
PNG
(5-[(E)-3-(2-Nitro-phenyl)-acryloylamino]-1H-[1,2,4...)
Show SMILES NC([NH-])=[NH+]CCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C=Cc2ccccc2[N+]([O-])=O)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46N12O7/c37-30(50)26(20-22-10-3-1-4-11-22)42-32(51)25(15-9-19-40-35(38)39)41-33(52)27(21-23-12-5-2-6-13-23)43-34(53)31-45-36(47-46-31)44-29(49)18-17-24-14-7-8-16-28(24)48(54)55/h1,3-4,7-8,10-11,14,16-18,23,25-27H,2,5-6,9,12-13,15,19-21H2,(H11,37,38,39,40,41,42,43,44,45,46,47,49,50,51,52,53)/t25-,26-,27-/m0/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-S-(p-F-Phe)-Har-L-Har-KY-NH2 binding to thrombin receptor (PAR-1) on membranes from CHRF cells


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077746
PNG
(5-Amino-1H-[1,2,4]triazole-3-carboxylic acid {(S)-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(N)[nH]1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O
Show InChI InChI=1S/C27H47N11O4/c28-21(39)19(14-16-8-3-1-4-9-16)34-23(40)18(12-7-13-32-26(29)30)33-24(41)20(15-17-10-5-2-6-11-17)35-25(42)22-36-27(31)38-37-22/h16-20H,1-15H2,(H2,28,39)(H,33,41)(H,34,40)(H,35,42)(H4,29,30,32)(H3,31,36,37,38)/t18-,19-,20-/m0/s1
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n/an/an/an/a 2.10E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077764
PNG
(3-Amino-N-{(S)-1-[(S)-1-((S)-1-carbamoyl-2-phenyl-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cccc(N)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C31H44N8O4/c32-23-14-7-13-22(19-23)28(41)39-26(18-21-11-5-2-6-12-21)30(43)37-24(15-8-16-36-31(34)35)29(42)38-25(27(33)40)17-20-9-3-1-4-10-20/h1,3-4,7,9-10,13-14,19,21,24-26H,2,5-6,8,11-12,15-18,32H2,(H2,33,40)(H,37,43)(H,38,42)(H,39,41)(H4,34,35,36)/t24-,25-,26-/m0/s1
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n/an/an/an/a 2.90E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1 (PAR1)


(Homo sapiens (Human))
BDBM50077733
PNG
(Benzo[b]thiophene-2-carboxylic acid {(S)-1-[(S)-1-...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C33H43N7O4S/c34-29(41)25(18-21-10-3-1-4-11-21)39-30(42)24(15-9-17-37-33(35)36)38-31(43)26(19-22-12-5-2-6-13-22)40-32(44)28-20-23-14-7-8-16-27(23)45-28/h1,3-4,7-8,10-11,14,16,20,22,24-26H,2,5-6,9,12-13,15,17-19H2,(H2,34,41)(H,38,43)(H,39,42)(H,40,44)(H4,35,36,37)/t24-,25-,26-/m0/s1
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n/an/an/an/a 8.30E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50077749
PNG
(5-((Z)-2-Fluoro-3-phenyl-acryloylamino)-1H-[1,2,4]...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1nnc(NC(=O)C(F)=Cc2ccccc2)[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H46FN11O5/c37-25(19-22-11-4-1-5-12-22)31(50)46-36-45-30(47-48-36)34(53)44-28(21-24-15-8-3-9-16-24)33(52)42-26(17-10-18-41-35(39)40)32(51)43-27(29(38)49)20-23-13-6-2-7-14-23/h1-2,4-7,11-14,19,24,26-28H,3,8-10,15-18,20-21H2,(H2,38,49)(H,42,52)(H,43,51)(H,44,53)(H4,39,40,41)(H2,45,46,47,48,50)/t26-,27-,28-/m0/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activation of human platelet aggregation (gel-filtered platelets) induced by alpha thrombin


Bioorg Med Chem Lett 9: 1423-8 (1999)


Article DOI: 10.1016/s0960-894x(99)00197-3
BindingDB Entry DOI: 10.7270/Q2R78DFP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%