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PubMed code 10411485

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079090
PNG
(CHEMBL90435 | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro...)
Show SMILES OC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H33Br2ClN4O4/c30-21-12-20-2-1-19-13-22(32)14-23(31)26(19)27(28(20)33-15-21)18-5-9-35(10-6-18)24(37)11-17-3-7-36(8-4-17)29(40)34-16-25(38)39/h12-15,17-18,27H,1-11,16H2,(H,34,40)(H,38,39)/t27-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079085
PNG
(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES OC(=O)c1cncc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C33H33Br2ClN4O4/c34-25-13-22-2-1-21-14-26(36)15-27(35)29(21)30(31(22)38-18-25)20-5-9-39(10-6-20)28(41)11-19-3-7-40(8-4-19)32(42)23-12-24(33(43)44)17-37-16-23/h12-20,30H,1-11H2,(H,43,44)/t30-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079075
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES NC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H34Br2ClN5O3/c30-21-12-20-2-1-19-13-22(32)14-23(31)26(19)27(28(20)34-15-21)18-5-9-36(10-6-18)25(39)11-17-3-7-37(8-4-17)29(40)35-16-24(33)38/h12-15,17-18,27H,1-11,16H2,(H2,33,38)(H,35,40)/t27-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079079
PNG
(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)C(=O)Cn3cncn3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C30H33Br2ClN6O2/c31-23-12-22-2-1-21-13-24(33)14-25(32)28(21)29(30(22)35-15-23)20-5-9-37(10-6-20)26(40)11-19-3-7-38(8-4-19)27(41)16-39-18-34-17-36-39/h12-15,17-20,29H,1-11,16H2/t29-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM14459
PNG
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079074
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H33Br2ClN4O2/c1-32-28(37)35-8-4-17(5-9-35)12-24(36)34-10-6-18(7-11-34)26-25-19(14-22(31)15-23(25)30)2-3-20-13-21(29)16-33-27(20)26/h13-18,26H,2-12H2,1H3,(H,32,37)/t26-/m1/s1
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n/an/a 1.90n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079089
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES CS(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C27H32Br2ClN3O3S/c1-37(35,36)33-10-4-17(5-11-33)12-24(34)32-8-6-18(7-9-32)26-25-19(14-22(30)15-23(25)29)2-3-20-13-21(28)16-31-27(20)26/h13-18,26H,2-12H2,1H3/t26-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079084
PNG
(CHEMBL432573 | [(4-{2-[4-((R)-3,10-Dibromo-8-chlor...)
Show SMILES CCOC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C31H37Br2ClN4O4/c1-2-42-27(40)18-36-31(41)38-9-5-19(6-10-38)13-26(39)37-11-7-20(8-12-37)29-28-21(15-24(34)16-25(28)33)3-4-22-14-23(32)17-35-30(22)29/h14-17,19-20,29H,2-13,18H2,1H3,(H,36,41)/t29-/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079091
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES NC(=O)CN1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H33Br2ClN4O2/c29-21-12-20-2-1-19-13-22(31)14-23(30)26(19)27(28(20)33-15-21)18-5-9-35(10-6-18)25(37)11-17-3-7-34(8-4-17)16-24(32)36/h12-15,17-18,27H,1-11,16H2,(H2,32,36)/t27-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079083
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES [O-][n+]1cccc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C32H33Br2ClN4O3/c33-25-15-23-4-3-22-16-26(35)17-27(34)29(22)30(31(23)36-18-25)21-7-12-37(13-8-21)28(40)14-20-5-10-38(11-6-20)32(41)24-2-1-9-39(42)19-24/h1-2,9,15-21,30H,3-8,10-14H2/t30-/m1/s1
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Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Hras Farnesyl protein transferase(FPT)


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079073
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES CN(C)C(=O)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C30H35Br2ClN4O3/c1-35(2)29(39)30(40)37-9-5-18(6-10-37)13-25(38)36-11-7-19(8-12-36)27-26-20(15-23(33)16-24(26)32)3-4-21-14-22(31)17-34-28(21)27/h14-19,27H,3-13H2,1-2H3/t27-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079076
PNG
(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES NC(=O)c1cncc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C33H34Br2ClN5O3/c34-25-13-22-2-1-21-14-26(36)15-27(35)29(21)30(31(22)39-18-25)20-5-9-40(10-6-20)28(42)11-19-3-7-41(8-4-19)33(44)24-12-23(32(37)43)16-38-17-24/h12-20,30H,1-11H2,(H2,37,43)/t30-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079070
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES [O-][n+]1ccc(cc1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C32H33Br2ClN4O3/c33-25-16-24-2-1-23-17-26(35)18-27(34)29(23)30(31(24)36-19-25)21-5-11-37(12-6-21)28(40)15-20-3-9-38(10-4-20)32(41)22-7-13-39(42)14-8-22/h7-8,13-14,16-21,30H,1-6,9-12,15H2/t30-/m1/s1
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n/an/a 2.5n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Hras Farnesyl protein transferase(FPT)


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079086
PNG
(3-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)C(=O)CC#N)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C29H31Br2ClN4O2/c30-22-14-21-2-1-20-15-23(32)16-24(31)27(20)28(29(21)34-17-22)19-6-11-36(12-7-19)26(38)13-18-4-9-35(10-5-18)25(37)3-8-33/h14-19,28H,1-7,9-13H2/t28-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Hras Farnesyl protein transferase(FPT)


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079077
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES NC(=O)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H31Br2ClN4O3/c29-20-12-19-2-1-18-13-21(31)14-22(30)24(18)25(26(19)33-15-20)17-5-9-34(10-6-17)23(36)11-16-3-7-35(8-4-16)28(38)27(32)37/h12-17,25H,1-11H2,(H2,32,37)/t25-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079072
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES NS(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C26H31Br2ClN4O3S/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)31-15-20)17-5-7-32(8-6-17)23(34)11-16-3-9-33(10-4-16)37(30,35)36/h12-17,25H,1-11H2,(H2,30,35,36)/t25-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079081
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES CCN(CC)C(=O)CN1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C32H41Br2ClN4O2/c1-3-38(4-2)29(41)20-37-11-7-21(8-12-37)15-28(40)39-13-9-22(10-14-39)31-30-23(17-26(35)18-27(30)34)5-6-24-16-25(33)19-36-32(24)31/h16-19,21-22,31H,3-15,20H2,1-2H3/t31-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079088
PNG
(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)C(=O)Cn3cccc3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H35Br2ClN4O2/c33-25-16-24-4-3-23-17-26(35)18-27(34)30(23)31(32(24)36-19-25)22-7-13-38(14-8-22)28(40)15-21-5-11-39(12-6-21)29(41)20-37-9-1-2-10-37/h1-2,9-10,16-19,21-22,31H,3-8,11-15,20H2/t31-/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079092
PNG
((S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Show SMILES C[C@H](N)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H35Br2ClN4O2/c1-17(33)29(38)36-8-4-18(5-9-36)12-25(37)35-10-6-19(7-11-35)27-26-20(14-23(32)15-24(26)31)2-3-21-13-22(30)16-34-28(21)27/h13-19,27H,2-12,33H2,1H3/t17-,27+/m0/s1
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n/an/a 5.20n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079080
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC(=O)N4CCOCC4)CC3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H39Br2ClN4O3/c33-25-16-24-2-1-23-17-26(35)18-27(34)30(23)31(32(24)36-19-25)22-5-9-38(10-6-22)28(40)15-21-3-7-37(8-4-21)20-29(41)39-11-13-42-14-12-39/h16-19,21-22,31H,1-15,20H2/t31-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079087
PNG
(2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,...)
Show SMILES NCC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H33Br2ClN4O2/c29-21-12-20-2-1-19-13-22(31)14-23(30)26(19)27(28(20)33-16-21)18-5-9-34(10-6-18)24(36)11-17-3-7-35(8-4-17)25(37)15-32/h12-14,16-18,27H,1-11,15,32H2/t27-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079091
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES NC(=O)CN1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H33Br2ClN4O2/c29-21-12-20-2-1-19-13-22(31)14-23(30)26(19)27(28(20)33-15-21)18-5-9-35(10-6-18)25(37)11-17-3-7-34(8-4-17)16-24(32)36/h12-15,17-18,27H,1-11,16H2,(H2,32,36)/t27-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079083
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES [O-][n+]1cccc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C32H33Br2ClN4O3/c33-25-15-23-4-3-22-16-26(35)17-27(34)29(22)30(31(23)36-18-25)21-7-12-37(13-8-21)28(40)14-20-5-10-38(11-6-20)32(41)24-2-1-9-39(42)19-24/h1-2,9,15-21,30H,3-8,10-14H2/t30-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079071
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES CN(C)S(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H35Br2ClN4O3S/c1-33(2)39(37,38)35-11-5-18(6-12-35)13-25(36)34-9-7-19(8-10-34)27-26-20(15-23(31)16-24(26)30)3-4-21-14-22(29)17-32-28(21)27/h14-19,27H,3-13H2,1-2H3/t27-/m1/s1
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n/an/a 7.80n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079078
PNG
((R)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Show SMILES C[C@@H](N)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H35Br2ClN4O2/c1-17(33)29(38)36-8-4-18(5-9-36)12-25(37)35-10-6-19(7-11-35)27-26-20(14-23(32)15-24(26)31)2-3-21-13-22(30)16-34-28(21)27/h13-19,27H,2-12,33H2,1H3/t17-,27-/m1/s1
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n/an/a 7.90n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079074
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H33Br2ClN4O2/c1-32-28(37)35-8-4-17(5-9-35)12-24(36)34-10-6-18(7-11-34)26-25-19(14-22(31)15-23(25)30)2-3-20-13-21(29)16-33-27(20)26/h13-18,26H,2-12H2,1H3,(H,32,37)/t26-/m1/s1
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n/an/a 8.5n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079071
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES CN(C)S(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H35Br2ClN4O3S/c1-33(2)39(37,38)35-11-5-18(6-12-35)13-25(36)34-9-7-19(8-10-34)27-26-20(15-23(31)16-24(26)30)3-4-21-14-22(29)17-32-28(21)27/h14-19,27H,3-13H2,1-2H3/t27-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079088
PNG
(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)C(=O)Cn3cccc3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H35Br2ClN4O2/c33-25-16-24-4-3-23-17-26(35)18-27(34)30(23)31(32(24)36-19-25)22-7-13-38(14-8-22)28(40)15-21-5-11-39(12-6-21)29(41)20-37-9-1-2-10-37/h1-2,9-10,16-19,21-22,31H,3-8,11-15,20H2/t31-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM14459
PNG
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079070
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES [O-][n+]1ccc(cc1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C32H33Br2ClN4O3/c33-25-16-24-2-1-23-17-26(35)18-27(34)29(23)30(31(24)36-19-25)21-5-11-37(12-6-21)28(40)15-20-3-9-38(10-4-20)32(41)22-7-13-39(42)14-8-22/h7-8,13-14,16-21,30H,1-6,9-12,15H2/t30-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079073
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES CN(C)C(=O)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C30H35Br2ClN4O3/c1-35(2)29(39)30(40)37-9-5-18(6-10-37)13-25(38)36-11-7-19(8-12-36)27-26-20(15-23(33)16-24(26)32)3-4-21-14-22(31)17-34-28(21)27/h14-19,27H,3-13H2,1-2H3/t27-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079082
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)S(=O)(=O)Cc3ccccc3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C33H36Br2ClN3O3S/c34-27-17-26-7-6-25-18-28(36)19-29(35)31(25)32(33(26)37-20-27)24-10-12-38(13-11-24)30(40)16-22-8-14-39(15-9-22)43(41,42)21-23-4-2-1-3-5-23/h1-5,17-20,22,24,32H,6-16,21H2/t32-/m1/s1
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n/an/a 17.1n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079076
PNG
(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES NC(=O)c1cncc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C33H34Br2ClN5O3/c34-25-13-22-2-1-21-14-26(36)15-27(35)29(21)30(31(22)39-18-25)20-5-9-40(10-6-20)28(42)11-19-3-7-41(8-4-19)33(44)24-12-23(32(37)43)16-38-17-24/h12-20,30H,1-11H2,(H2,37,43)/t30-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079084
PNG
(CHEMBL432573 | [(4-{2-[4-((R)-3,10-Dibromo-8-chlor...)
Show SMILES CCOC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C31H37Br2ClN4O4/c1-2-42-27(40)18-36-31(41)38-9-5-19(6-10-38)13-26(39)37-11-7-20(8-12-37)29-28-21(15-24(34)16-25(28)33)3-4-22-14-23(32)17-35-30(22)29/h14-17,19-20,29H,2-13,18H2,1H3,(H,36,41)/t29-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079075
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES NC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H34Br2ClN5O3/c30-21-12-20-2-1-19-13-22(32)14-23(31)26(19)27(28(20)34-15-21)18-5-9-36(10-6-18)25(39)11-17-3-7-37(8-4-17)29(40)35-16-24(33)38/h12-15,17-18,27H,1-11,16H2,(H2,33,38)(H,35,40)/t27-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079080
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC(=O)N4CCOCC4)CC3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H39Br2ClN4O3/c33-25-16-24-2-1-23-17-26(35)18-27(34)30(23)31(32(24)36-19-25)22-5-9-38(10-6-22)28(40)15-21-3-7-37(8-4-21)20-29(41)39-11-13-42-14-12-39/h16-19,21-22,31H,1-15,20H2/t31-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079087
PNG
(2-[1-(2-Amino-acetyl)-piperidin-4-yl]-1-[4-((R)-3,...)
Show SMILES NCC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C28H33Br2ClN4O2/c29-21-12-20-2-1-19-13-22(31)14-23(30)26(19)27(28(20)33-16-21)18-5-9-34(10-6-18)24(36)11-17-3-7-35(8-4-17)25(37)15-32/h12-14,16-18,27H,1-11,15,32H2/t27-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079089
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES CS(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C27H32Br2ClN3O3S/c1-37(35,36)33-10-4-17(5-11-33)12-24(34)32-8-6-18(7-9-32)26-25-19(14-22(30)15-23(25)29)2-3-20-13-21(28)16-31-27(20)26/h13-18,26H,2-12H2,1H3/t26-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079072
PNG
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)
Show SMILES NS(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C26H31Br2ClN4O3S/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)31-15-20)17-5-7-32(8-6-17)23(34)11-16-3-9-33(10-4-16)37(30,35)36/h12-17,25H,1-11H2,(H2,30,35,36)/t25-/m1/s1
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n/an/a 35n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079078
PNG
((R)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Show SMILES C[C@@H](N)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H35Br2ClN4O2/c1-17(33)29(38)36-8-4-18(5-9-36)12-25(37)35-10-6-19(7-11-35)27-26-20(14-23(32)15-24(26)31)2-3-21-13-22(30)16-34-28(21)27/h13-19,27H,2-12,33H2,1H3/t17-,27-/m1/s1
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n/an/a 39n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079081
PNG
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES CCN(CC)C(=O)CN1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C32H41Br2ClN4O2/c1-3-38(4-2)29(41)20-37-11-7-21(8-12-37)15-28(40)39-13-9-22(10-14-39)31-30-23(17-26(35)18-27(30)34)5-6-24-16-25(33)19-36-32(24)31/h16-19,21-22,31H,3-15,20H2,1-2H3/t31-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079093
PNG
(2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,1...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)S(=O)(=O)c3ccccc3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C32H34Br2ClN3O3S/c33-25-17-24-7-6-23-18-26(35)19-28(34)30(23)31(32(24)36-20-25)22-10-12-37(13-11-22)29(39)16-21-8-14-38(15-9-21)42(40,41)27-4-2-1-3-5-27/h1-5,17-22,31H,6-16H2/t31-/m1/s1
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n/an/a 76.1n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT).


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079092
PNG
((S)-2-Amino-1-(4-{2-[4-((R)-3,10-dibromo-8-chloro-...)
Show SMILES C[C@H](N)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H35Br2ClN4O2/c1-17(33)29(38)36-8-4-18(5-9-36)12-25(37)35-10-6-19(7-11-35)27-26-20(14-23(32)15-24(26)31)2-3-21-13-22(30)16-34-28(21)27/h13-19,27H,2-12,33H2,1H3/t17-,27+/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079082
PNG
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)
Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)S(=O)(=O)Cc3ccccc3)c3ncc(Br)cc3CCc2c1
Show InChI InChI=1S/C33H36Br2ClN3O3S/c34-27-17-26-7-6-25-18-28(36)19-29(35)31(25)32(33(26)37-20-27)24-10-12-38(13-11-24)30(40)16-22-8-14-39(15-9-22)43(41,42)21-23-4-2-1-3-5-23/h1-5,17-20,22,24,32H,6-16,21H2/t32-/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079090
PNG
(CHEMBL90435 | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro...)
Show SMILES OC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C29H33Br2ClN4O4/c30-21-12-20-2-1-19-13-22(32)14-23(31)26(19)27(28(20)33-15-21)18-5-9-35(10-6-18)24(37)11-17-3-7-36(8-4-17)29(40)34-16-25(38)39/h12-15,17-18,27H,1-11,16H2,(H,34,40)(H,38,39)/t27-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (human))
BDBM50079085
PNG
(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)
Show SMILES OC(=O)c1cncc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1
Show InChI InChI=1S/C33H33Br2ClN4O4/c34-25-13-22-2-1-21-14-26(36)15-27(35)29(21)30(31(22)38-18-25)20-5-9-39(10-6-20)28(41)11-19-3-7-40(8-4-19)32(42)23-12-24(33(43)44)17-37-16-23/h12-20,30H,1-11H2,(H,43,44)/t30-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.


J Med Chem 42: 2651-61 (1999)


Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%