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PubMed code 10509928

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081496
PNG
(5-((S)-1-Azetidin-2-ylmethoxy)-pyrimidine | CHEMBL...)
Show SMILES C(Oc1cncnc1)[C@@H]1CCN1
Show InChI InChI=1S/C8H11N3O/c1-2-11-7(1)5-12-8-3-9-6-10-4-8/h3-4,6-7,11H,1-2,5H2/t7-/m0/s1
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PubMed
0.130n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50049756
PNG
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Show SMILES CN1CCC[C@H]1COc1cccnc1
Show InChI InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1
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PubMed
0.150n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081490
PNG
(5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyrimidine...)
Show SMILES CN1CCC[C@H]1COc1cncnc1
Show InChI InChI=1S/C10H15N3O/c1-13-4-2-3-9(13)7-14-10-5-11-8-12-6-10/h5-6,8-9H,2-4,7H2,1H3/t9-/m0/s1
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2.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081484
PNG
(3-((S)-1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHE...)
Show SMILES CN1CC[C@@H](C1)Oc1cccnc1
Show InChI InChI=1S/C10H14N2O/c1-12-6-4-10(8-12)13-9-3-2-5-11-7-9/h2-3,5,7,10H,4,6,8H2,1H3/t10-/m0/s1
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2.70n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081483
PNG
(3-((R)-1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHE...)
Show SMILES CN1CC[C@H](C1)Oc1cccnc1
Show InChI InChI=1S/C10H14N2O/c1-12-6-4-10(8-12)13-9-3-2-5-11-7-9/h2-3,5,7,10H,4,6,8H2,1H3/t10-/m1/s1
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4.40n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081487
PNG
(5-((S)-1-Methyl-azetidin-2-ylmethoxy)-pyrimidine |...)
Show SMILES CN1CC[C@H]1COc1cncnc1
Show InChI InChI=1S/C9H13N3O/c1-12-3-2-8(12)6-13-9-4-10-7-11-5-9/h4-5,7-8H,2-3,6H2,1H3/t8-/m0/s1
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6.5n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081473
PNG
(5-(1-Methyl-pyrrolidin-3-yloxy)-pyrimidine | CHEMB...)
Show SMILES CN1CCC(C1)Oc1cncnc1
Show InChI InChI=1S/C9H13N3O/c1-12-3-2-8(6-12)13-9-4-10-7-11-5-9/h4-5,7-8H,2-3,6H2,1H3
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12n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081476
PNG
(3-((S)-1-Azetidin-2-ylmethoxy)-6-chloro-pyridazine...)
Show SMILES Clc1ccc(OC[C@@H]2CCN2)nn1
Show InChI InChI=1S/C8H10ClN3O/c9-7-1-2-8(12-11-7)13-5-6-3-4-10-6/h1-2,6,10H,3-5H2/t6-/m0/s1
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15n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081475
PNG
(2-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyrazine |...)
Show SMILES CN1CCC[C@H]1COc1cnccn1
Show InChI InChI=1S/C10H15N3O/c1-13-6-2-3-9(13)8-14-10-7-11-4-5-12-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1
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16n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081478
PNG
(3-((S)-1-Methyl-azetidin-2-ylmethoxy)-pyridazine |...)
Show SMILES CN1CC[C@H]1COc1cccnn1
Show InChI InChI=1S/C9H13N3O/c1-12-6-4-8(12)7-13-9-3-2-5-10-11-9/h2-3,5,8H,4,6-7H2,1H3/t8-/m0/s1
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28n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081497
PNG
(3-Chloro-6-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Show SMILES CN1CCC[C@H]1COc1ccc(Cl)nn1
Show InChI InChI=1S/C10H14ClN3O/c1-14-6-2-3-8(14)7-15-10-5-4-9(11)12-13-10/h4-5,8H,2-3,6-7H2,1H3/t8-/m0/s1
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29n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081479
PNG
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridazine...)
Show SMILES CN1CCC[C@H]1COc1cccnn1
Show InChI InChI=1S/C10H15N3O/c1-13-7-3-4-9(13)8-14-10-5-2-6-11-12-10/h2,5-6,9H,3-4,7-8H2,1H3/t9-/m0/s1
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42n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081477
PNG
(3-Chloro-6-(1-methyl-pyrrolidin-3-yloxy)-pyridazin...)
Show SMILES CN1CCC(C1)Oc1ccc(Cl)nn1
Show InChI InChI=1S/C9H12ClN3O/c1-13-5-4-7(6-13)14-9-3-2-8(10)11-12-9/h2-3,7H,4-6H2,1H3
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46n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081474
PNG
(3-Chloro-6-((S)-1-methyl-azetidin-2-ylmethoxy)-pyr...)
Show SMILES CN1CC[C@H]1COc1ccc(Cl)nn1
Show InChI InChI=1S/C9H12ClN3O/c1-13-5-4-7(13)6-14-9-3-2-8(10)11-12-9/h2-3,7H,4-6H2,1H3/t7-/m0/s1
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64n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081481
PNG
(3-Chloro-6-((R)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)
Show SMILES CN1CCC[C@@H]1COc1ccc(Cl)nn1
Show InChI InChI=1S/C10H14ClN3O/c1-14-6-2-3-8(14)7-15-10-5-4-9(11)12-13-10/h4-5,8H,2-3,6-7H2,1H3/t8-/m1/s1
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85n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081486
PNG
(2-(2-Pyrrolidin-1-yl-ethoxy)-pyridine | CHEMBL9297...)
Show SMILES C(CN1CCCC1)Oc1ccccn1
Show InChI InChI=1S/C11H16N2O/c1-2-6-12-11(5-1)14-10-9-13-7-3-4-8-13/h1-2,5-6H,3-4,7-10H2
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160n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081480
PNG
(3-(2-Pyrrolidin-1-yl-ethoxy)-pyridine | CHEMBL3284...)
Show SMILES C(CN1CCCC1)Oc1cccnc1
Show InChI InChI=1S/C11H16N2O/c1-2-7-13(6-1)8-9-14-11-4-3-5-12-10-11/h3-5,10H,1-2,6-9H2
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240n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081485
PNG
(2-(1-Methyl-pyrrolidin-3-yloxy)-pyrazine | CHEMBL9...)
Show SMILES CN1CCC(C1)Oc1cnccn1
Show InChI InChI=1S/C9H13N3O/c1-12-5-2-8(7-12)13-9-6-10-3-4-11-9/h3-4,6,8H,2,5,7H2,1H3
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359n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081488
PNG
(2-((R)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyrazine |...)
Show SMILES CN1CCC[C@@H]1COc1cnccn1
Show InChI InChI=1S/C10H15N3O/c1-13-6-2-3-9(13)8-14-10-7-11-4-5-12-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m1/s1
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406n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081498
PNG
(2-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Show SMILES CN1CCC[C@H]1COc1ccccn1
Show InChI InChI=1S/C11H16N2O/c1-13-8-4-5-10(13)9-14-11-6-2-3-7-12-11/h2-3,6-7,10H,4-5,8-9H2,1H3/t10-/m0/s1
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495n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081494
PNG
(2-(2-Pyrrolidin-1-yl-ethoxy)-pyrazine | CHEMBL9392...)
Show SMILES C(CN1CCCC1)Oc1cnccn1
Show InChI InChI=1S/C10H15N3O/c1-2-6-13(5-1)7-8-14-10-9-11-3-4-12-10/h3-4,9H,1-2,5-8H2
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560n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081495
PNG
(2-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyrimidine...)
Show SMILES CN1CCC[C@H]1COc1ncccn1
Show InChI InChI=1S/C10H15N3O/c1-13-7-2-4-9(13)8-14-10-11-5-3-6-12-10/h3,5-6,9H,2,4,7-8H2,1H3/t9-/m0/s1
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1.22E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081491
PNG
(3-Chloro-6-(2-pyrrolidin-1-yl-ethoxy)-pyridazine |...)
Show SMILES Clc1ccc(OCCN2CCCC2)nn1
Show InChI InChI=1S/C10H14ClN3O/c11-9-3-4-10(13-12-9)15-8-7-14-5-1-2-6-14/h3-4H,1-2,5-8H2
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1.30E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081489
PNG
(2-(2-Pyrrolidin-1-yl-ethoxy)-pyrimidine | CHEMBL94...)
Show SMILES C(CN1CCCC1)Oc1ncccn1
Show InChI InChI=1S/C10H15N3O/c1-2-7-13(6-1)8-9-14-10-11-4-3-5-12-10/h3-5H,1-2,6-9H2
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1.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081492
PNG
(4-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Show SMILES CN1CCC[C@H]1COc1ccncc1
Show InChI InChI=1S/C11H16N2O/c1-13-8-2-3-10(13)9-14-11-4-6-12-7-5-11/h4-7,10H,2-3,8-9H2,1H3/t10-/m0/s1
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7.91E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha9/alpha10


(Rattus norvegicus)
BDBM50081487
PNG
(5-((S)-1-Methyl-azetidin-2-ylmethoxy)-pyrimidine |...)
Show SMILES CN1CC[C@H]1COc1cncnc1
Show InChI InChI=1S/C9H13N3O/c1-12-3-2-8(12)6-13-9-4-10-7-11-5-9/h4-5,7-8H,2-3,6H2,1H3/t8-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [125I]-alpha-BgT binding to rat brain membran...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha9/alpha10


(Rattus norvegicus)
BDBM50081483
PNG
(3-((R)-1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHE...)
Show SMILES CN1CC[C@H](C1)Oc1cccnc1
Show InChI InChI=1S/C10H14N2O/c1-12-6-4-10(8-12)13-9-3-2-5-11-7-9/h2-3,5,7,10H,4,6,8H2,1H3/t10-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [125I]-alpha-BgT binding to rat brain membran...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha9/alpha10


(Rattus norvegicus)
BDBM50081484
PNG
(3-((S)-1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHE...)
Show SMILES CN1CC[C@@H](C1)Oc1cccnc1
Show InChI InChI=1S/C10H14N2O/c1-12-6-4-10(8-12)13-9-3-2-5-11-7-9/h2-3,5,7,10H,4,6,8H2,1H3/t10-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [125I]-alpha-BgT binding to rat brain membran...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081493
PNG
(2-(1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHEMBL8...)
Show SMILES CN1CCC(C1)Oc1ccccn1
Show InChI InChI=1S/C10H14N2O/c1-12-7-5-9(8-12)13-10-4-2-3-6-11-10/h2-4,6,9H,5,7-8H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Nicotinic acetylcholine receptor alpha9/alpha10


(Rattus norvegicus)
BDBM50081496
PNG
(5-((S)-1-Azetidin-2-ylmethoxy)-pyrimidine | CHEMBL...)
Show SMILES C(Oc1cncnc1)[C@@H]1CCN1
Show InChI InChI=1S/C8H11N3O/c1-2-11-7(1)5-12-8-3-9-6-10-4-8/h3-4,6-7,11H,1-2,5H2/t7-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [125I]-alpha-BgT binding to rat brain membran...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit


(Rattus norvegicus (Rat))
BDBM50081482
PNG
(3-(1-Methyl-pyrrolidin-3-yloxymethyl)-pyridine | C...)
Show SMILES CN1CCC(C1)OCc1cccnc1
Show InChI InChI=1S/C11H16N2O/c1-13-6-4-11(8-13)14-9-10-3-2-5-12-7-10/h2-3,5,7,11H,4,6,8-9H2,1H3
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1.19E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra...


Bioorg Med Chem Lett 9: 2747-52 (1999)


Article DOI: 10.1016/s0960-894x(99)00462-x
BindingDB Entry DOI: 10.7270/Q20Z72HG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%