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Found 33 Enz. Inhib. hit(s) with all data for entry = 50009387
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082920(6-Carbazol-9-ylmethyl-pteridine-2,4-diamine | CHEM...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082920(6-Carbazol-9-ylmethyl-pteridine-2,4-diamine | CHEM...)
Affinity DataIC50:  55nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082920(6-Carbazol-9-ylmethyl-pteridine-2,4-diamine | CHEM...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity of the compound against DHFR(Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50:  910nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity of the compound against DHFR(Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibitory activity of the compound against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibitory activity of the compound against DHFR(Dihydrofolate reductase) from Rat liver .More data for this Ligand-Target Pair