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PubMed code 10753470

Compile data set for download or QSAR
Found 95 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50027473
PNG
(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Show SMILES CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC
Show InChI InChI=1S/C25H32N2O3/c1-4-23(28)27(22-13-9-6-10-14-22)25(24(29)30-3)16-18-26(19-20(25)2)17-15-21-11-7-5-8-12-21/h5-14,20H,4,15-19H2,1-3H3/t20-,25+/m1/s1
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PubMed
0.140n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087016
PNG
(8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)
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0.520n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing human Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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0.700n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087011
PNG
(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-18-7-5-11-21-20(18)10-6-12-22(21)26-15-13-24(14-16-26)23(28)25-17-27(24)19-8-3-2-4-9-19/h2-5,7-9,11,22H,6,10,12-17H2,1H3,(H,25,28)
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1.40n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing human Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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2.10n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087022
PNG
(8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)19-8-2-1-3-9-19)10-12-24(13-11-22)20-14-17-6-4-5-7-18(17)15-20/h1-9,20H,10-16H2,(H,23,26)
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2.5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing human Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087002
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087004
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES CN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3c(Cl)ccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C24H27Cl2N3O/c1-27-16-29(17-5-3-2-4-6-17)24(23(27)30)11-13-28(14-12-24)18-7-8-19-20(15-18)22(26)10-9-21(19)25/h2-6,9-10,18H,7-8,11-16H2,1H3
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2.60n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087020
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087012
PNG
(8-(5-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-15-19(9-10-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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2.90n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087003
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2
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3.30n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087004
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES CN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3c(Cl)ccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C24H27Cl2N3O/c1-27-16-29(17-5-3-2-4-6-17)24(23(27)30)11-13-28(14-12-24)18-7-8-19-20(15-18)22(26)10-9-21(19)25/h2-6,9-10,18H,7-8,11-16H2,1H3
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3.30n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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3.40n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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5.30n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50027473
PNG
(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Show SMILES CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC
Show InChI InChI=1S/C25H32N2O3/c1-4-23(28)27(22-13-9-6-10-14-22)25(24(29)30-3)16-18-26(19-20(25)2)17-15-21-11-7-5-8-12-21/h5-14,20H,4,15-19H2,1-3H3/t20-,25+/m1/s1
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5.5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087005
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)
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5.60n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087007
PNG
(8-(7-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CCC(Cc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-17-7-9-21(15-18(17)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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5.80n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087020
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087018
PNG
(3-Allyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphtha...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(CC=C)C2=O)c1ccccc1
Show InChI InChI=1S/C26H29Cl2N3O/c1-2-14-30-18-31(19-6-4-3-5-7-19)26(25(30)32)12-15-29(16-13-26)20-8-9-21-22(17-20)24(28)11-10-23(21)27/h2-7,10-11,20H,1,8-9,12-18H2
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5.90n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087016
PNG
(8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)
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5.90n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087013
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-2-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc2C1
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)20-8-2-1-3-9-20)12-14-25(15-13-23)21-11-10-18-6-4-5-7-19(18)16-21/h1-9,21H,10-17H2,(H,24,27)
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6.30n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087018
PNG
(3-Allyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphtha...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(CC=C)C2=O)c1ccccc1
Show InChI InChI=1S/C26H29Cl2N3O/c1-2-14-30-18-31(19-6-4-3-5-7-19)26(25(30)32)12-15-29(16-13-26)20-8-9-21-22(17-20)24(28)11-10-23(21)27/h2-7,10-11,20H,1,8-9,12-18H2
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6.80n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087003
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2
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7.20n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087005
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)
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7.20n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087010
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-9-10-19(15-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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7.30n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087009
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES COCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c1-31-18-28-17-29(20-7-3-2-4-8-20)25(24(28)30)12-14-27(15-13-25)21-11-10-19-6-5-9-23(26)22(19)16-21/h2-9,21H,10-18H2,1H3
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7.5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087019
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m1/s1
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8.40n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087009
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES COCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c1-31-18-28-17-29(20-7-3-2-4-8-20)25(24(28)30)12-14-27(15-13-25)21-11-10-19-6-5-9-23(26)22(19)16-21/h2-9,21H,10-18H2,1H3
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8.5n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087012
PNG
(8-(5-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-15-19(9-10-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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8.90n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087021
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m0/s1
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10n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087007
PNG
(8-(7-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CCC(Cc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-17-7-9-21(15-18(17)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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11n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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11n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087002
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m1/s1
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12n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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13n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087021
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m0/s1
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13n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087006
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2
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15n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087014
PNG
(3-Benzyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphth...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(Cc1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C30H31Cl2N3O/c31-27-13-14-28(32)26-19-24(11-12-25(26)27)33-17-15-30(16-18-33)29(36)34(20-22-7-3-1-4-8-22)21-35(30)23-9-5-2-6-10-23/h1-10,13-14,24H,11-12,15-21H2
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15n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087013
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-2-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc2C1
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)20-8-2-1-3-9-20)12-14-25(15-13-23)21-11-10-18-6-4-5-7-19(18)16-21/h1-9,21H,10-17H2,(H,24,27)
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15n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087003
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2
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16n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087007
PNG
(8-(7-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CCC(Cc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-17-7-9-21(15-18(17)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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16n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087010
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-9-10-19(15-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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17n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087004
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES CN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3c(Cl)ccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C24H27Cl2N3O/c1-27-16-29(17-5-3-2-4-6-17)24(23(27)30)11-13-28(14-12-24)18-7-8-19-20(15-18)22(26)10-9-21(19)25/h2-6,9-10,18H,7-8,11-16H2,1H3
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17n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087021
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m0/s1
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17n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087009
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES COCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c1-31-18-28-17-29(20-7-3-2-4-8-20)25(24(28)30)12-14-27(15-13-25)21-11-10-19-6-5-9-23(26)22(19)16-21/h2-9,21H,10-18H2,1H3
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18n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087014
PNG
(3-Benzyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphth...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(Cc1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C30H31Cl2N3O/c31-27-13-14-28(32)26-19-24(11-12-25(26)27)33-17-15-30(16-18-33)29(36)34(20-22-7-3-1-4-8-22)21-35(30)23-9-5-2-6-10-23/h1-10,13-14,24H,11-12,15-21H2
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19n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087012
PNG
(8-(5-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-15-19(9-10-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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21n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087019
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m1/s1
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21n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50027473
PNG
(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Show SMILES CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC
Show InChI InChI=1S/C25H32N2O3/c1-4-23(28)27(22-13-9-6-10-14-22)25(24(29)30-3)16-18-26(19-20(25)2)17-15-21-11-7-5-8-12-21/h5-14,20H,4,15-19H2,1-3H3/t20-,25+/m1/s1
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24n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087016
PNG
(8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)
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26n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087022
PNG
(8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)19-8-2-1-3-9-19)10-12-24(13-11-22)20-14-17-6-4-5-7-18(17)15-20/h1-9,20H,10-16H2,(H,23,26)
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26n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087018
PNG
(3-Allyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphtha...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(CC=C)C2=O)c1ccccc1
Show InChI InChI=1S/C26H29Cl2N3O/c1-2-14-30-18-31(19-6-4-3-5-7-19)26(25(30)32)12-15-29(16-13-26)20-8-9-21-22(17-20)24(28)11-10-23(21)27/h2-7,10-11,20H,1,8-9,12-18H2
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26n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087006
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2
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29n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087011
PNG
(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-18-7-5-11-21-20(18)10-6-12-22(21)26-15-13-24(14-16-26)23(28)25-17-27(24)19-8-3-2-4-9-19/h2-5,7-9,11,22H,6,10,12-17H2,1H3,(H,25,28)
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32n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087020
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m0/s1
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40n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087011
PNG
(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-18-7-5-11-21-20(18)10-6-12-22(21)26-15-13-24(14-16-26)23(28)25-17-27(24)19-8-3-2-4-9-19/h2-5,7-9,11,22H,6,10,12-17H2,1H3,(H,25,28)
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44n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087005
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)
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44n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087002
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m1/s1
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46n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087019
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m1/s1
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47n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087013
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-2-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc2C1
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)20-8-2-1-3-9-20)12-14-25(15-13-23)21-11-10-18-6-4-5-7-19(18)16-21/h1-9,21H,10-17H2,(H,24,27)
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47n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087010
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-9-10-19(15-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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48n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087014
PNG
(3-Benzyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphth...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(Cc1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C30H31Cl2N3O/c31-27-13-14-28(32)26-19-24(11-12-25(26)27)33-17-15-30(16-18-33)29(36)34(20-22-7-3-1-4-8-22)21-35(30)23-9-5-2-6-10-23/h1-10,13-14,24H,11-12,15-21H2
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52n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087006
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2
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61n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087017
PNG
(8-(6-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CC(CCc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-18-15-21(9-7-17(18)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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77n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor mu 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087014
PNG
(3-Benzyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphth...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CN(Cc1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C30H31Cl2N3O/c31-27-13-14-28(32)26-19-24(11-12-25(26)27)33-17-15-30(16-18-33)29(36)34(20-22-7-3-1-4-8-22)21-35(30)23-9-5-2-6-10-23/h1-10,13-14,24H,11-12,15-21H2
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146n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087017
PNG
(8-(6-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CC(CCc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-18-15-21(9-7-17(18)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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149n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (human))
BDBM50087022
PNG
(8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)19-8-2-1-3-9-19)10-12-24(13-11-22)20-14-17-6-4-5-7-18(17)15-20/h1-9,20H,10-16H2,(H,23,26)
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161n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087017
PNG
(8-(6-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CC(CCc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-18-15-21(9-7-17(18)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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218n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087009
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES COCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c1-31-18-28-17-29(20-7-3-2-4-8-20)25(24(28)30)12-14-27(15-13-25)21-11-10-19-6-5-9-23(26)22(19)16-21/h2-9,21H,10-18H2,1H3
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240n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087016
PNG
(8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)
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250n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087003
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES OCCN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3cccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C25H30ClN3O2/c26-23-8-4-5-19-9-10-21(17-22(19)23)27-13-11-25(12-14-27)24(31)28(15-16-30)18-29(25)20-6-2-1-3-7-20/h1-8,21,30H,9-18H2
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285n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087004
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES CN1CN(c2ccccc2)C2(CCN(CC2)C2CCc3c(Cl)ccc(Cl)c3C2)C1=O
Show InChI InChI=1S/C24H27Cl2N3O/c1-27-16-29(17-5-3-2-4-6-17)24(23(27)30)11-13-28(14-12-24)18-7-8-19-20(15-18)22(26)10-9-21(19)25/h2-6,9-10,18H,7-8,11-16H2,1H3
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313n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087020
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m0/s1
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415n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087012
PNG
(8-(5-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-15-19(9-10-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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450n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087011
PNG
(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-18-7-5-11-21-20(18)10-6-12-22(21)26-15-13-24(14-16-26)23(28)25-17-27(24)19-8-3-2-4-9-19/h2-5,7-9,11,22H,6,10,12-17H2,1H3,(H,25,28)
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460n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087007
PNG
(8-(7-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CCC(Cc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-17-7-9-21(15-18(17)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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480n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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480n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087006
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CN(CC(=O)c1ccccc1)C2=O)c1ccccc1
Show InChI InChI=1S/C31H32ClN3O2/c32-28-13-7-10-23-14-15-26(20-27(23)28)33-18-16-31(17-19-33)30(37)34(21-29(36)24-8-3-1-4-9-24)22-35(31)25-11-5-2-6-12-25/h1-13,26H,14-22H2
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510n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087002
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)/t21-/m1/s1
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530n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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540n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087019
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2C[C@@H](CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)/t17-/m1/s1
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587n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087013
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-2-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc2C1
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)20-8-2-1-3-9-20)12-14-25(15-13-23)21-11-10-18-6-4-5-7-19(18)16-21/h1-9,21H,10-17H2,(H,24,27)
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620n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087005
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)
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680n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087022
PNG
(8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)19-8-2-1-3-9-19)10-12-24(13-11-22)20-14-17-6-4-5-7-18(17)15-20/h1-9,20H,10-16H2,(H,23,26)
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710n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087010
PNG
(8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1cccc2CCC(Cc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-21-8-4-5-17-9-10-19(15-20(17)21)26-13-11-23(12-14-26)22(28)25-16-27(23)18-6-2-1-3-7-18/h1-8,19H,9-16H2,(H,25,28)
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1.41E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (human))
BDBM50087017
PNG
(8-(6-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-...)
Show SMILES Clc1ccc2CC(CCc2c1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H26ClN3O/c24-19-8-6-18-15-21(9-7-17(18)14-19)26-12-10-23(11-13-26)22(28)25-16-27(23)20-4-2-1-3-5-20/h1-6,8,14,21H,7,9-13,15-16H2,(H,25,28)
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1.80E+3n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing human Opioid receptor delta 1


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087011
PNG
(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-18-7-5-11-21-20(18)10-6-12-22(21)26-15-13-24(14-16-26)23(28)25-17-27(24)19-8-3-2-4-9-19/h2-5,7-9,11,22H,6,10,12-17H2,1H3,(H,25,28)
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n/an/an/an/a 510n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087016
PNG
(8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)
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n/an/an/an/a 2.50E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration of the required to stimulate binding of GTPgammaS to mu1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087015
PNG
(1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCCc2ccccc12
Show InChI InChI=1S/C23H27N3O/c27-22-23(26(17-24-22)19-9-2-1-3-10-19)13-15-25(16-14-23)21-12-6-8-18-7-4-5-11-20(18)21/h1-5,7,9-11,21H,6,8,12-17H2,(H,24,27)
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n/an/an/an/a 87n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087008
PNG
(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)18-7-2-1-3-8-18)12-14-24(15-13-22)20-11-10-17-6-4-5-9-19(17)20/h1-9,20H,10-16H2,(H,23,26)
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n/an/an/an/a 7.90E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087016
PNG
(8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C25H25N3O/c29-24-25(28(17-26-24)20-9-2-1-3-10-20)12-14-27(15-13-25)22-16-19-8-4-6-18-7-5-11-21(22)23(18)19/h1-11,22H,12-17H2,(H,26,29)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087005
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)
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n/an/an/an/a 310n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration of the required to stimulate binding of GTPgammaS to human mu1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087005
PNG
(8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES Clc1ccc(Cl)c2CC(CCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C23H25Cl2N3O/c24-20-8-9-21(25)19-14-17(6-7-18(19)20)27-12-10-23(11-13-27)22(29)26-15-28(23)16-4-2-1-3-5-16/h1-5,8-9,17H,6-7,10-15H2,(H,26,29)
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n/an/an/an/a 1.50E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to human ORL1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (human))
BDBM50087011
PNG
(8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-...)
Show SMILES Cc1cccc2C(CCCc12)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-18-7-5-11-21-20(18)10-6-12-22(21)26-15-13-24(14-16-26)23(28)25-17-27(24)19-8-3-2-4-9-19/h2-5,7-9,11,22H,6,10,12-17H2,1H3,(H,25,28)
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n/an/an/an/a 3.70E+3n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to mu1 receptor was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50004178
PNG
(Nociceptin | Nociceptin/orphanin FQ | ORPHANIN FQ)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
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PubMed
n/an/an/an/a 63n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM50087022
PNG
(8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Show SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1Cc2ccccc2C1
Show InChI InChI=1S/C22H25N3O/c26-21-22(25(16-23-21)19-8-2-1-3-9-19)10-12-24(13-11-22)20-14-17-6-4-5-7-18(17)15-20/h1-9,20H,10-16H2,(H,23,26)
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Article
PubMed
n/an/an/an/a 500n/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assay


J Med Chem 43: 1329-38 (2001)


Article DOI: 10.1021/jm991129q
BindingDB Entry DOI: 10.7270/Q2ZG6SZG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%