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PubMed code 11311060

Compile data set for download or QSAR
Found 12 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucagon receptor


(Rattus norvegicus)
BDBM50098571
PNG
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)
Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098563
PNG
(CHEMBL413890 | Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C148H221N41O47S/c1-70(2)54-95(131(221)171-94(49-53-237-11)130(220)179-102(61-111(154)202)140(230)188-117(74(8)194)120(155)210)174-135(225)101(60-81-64-162-86-29-19-18-28-84(81)86)178-128(218)92(43-47-110(153)201)172-144(234)116(72(5)6)187-138(228)99(56-77-24-14-12-15-25-77)177-136(226)103(62-114(206)207)180-127(217)91(42-46-109(152)200)165-121(211)73(7)164-124(214)88(31-22-51-160-147(156)157)167-125(215)89(32-23-52-161-148(158)159)169-142(232)106(68-192)184-137(227)104(63-115(208)209)181-132(222)96(55-71(3)4)173-133(223)97(58-79-33-37-82(197)38-34-79)175-126(216)87(30-20-21-50-149)168-141(231)105(67-191)183-134(224)98(59-80-35-39-83(198)40-36-80)176-129(219)93(44-48-113(204)205)170-143(233)107(69-193)185-146(236)119(76(10)196)189-139(229)100(57-78-26-16-13-17-27-78)182-145(235)118(75(9)195)186-112(203)65-163-123(213)90(41-45-108(151)199)166-122(212)85(150)66-190/h12-19,24-29,33-40,64,70-76,85,87-107,116-119,162,190-198H,20-23,30-32,41-63,65-69,149-150H2,1-11H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,202)(H2,155,210)(H,163,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,231)(H,169,232)(H,170,233)(H,171,221)(H,172,234)(H,173,223)(H,174,225)(H,175,216)(H,176,219)(H,177,226)(H,178,218)(H,179,220)(H,180,217)(H,181,222)(H,182,235)(H,183,224)(H,184,227)(H,185,236)(H,186,203)(H,187,228)(H,188,230)(H,189,229)(H,204,205)(H,206,207)(H,208,209)(H4,156,157,160)(H4,158,159,161)/t73-,74+,75+,76+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.75n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098573
PNG
(CHEMBL267876 | N-trinitrophenyl-His-Ser-Gln-Gly-Th...)
Show InChI InChI=1S/C160H229N49O54S/c1-74(2)52-99(139(239)186-98(47-51-264-11)138(238)194-107(62-120(164)222)150(250)205-126(78(8)214)130(165)230)189-143(243)105(58-85-66-176-91-29-19-18-28-90(85)91)193-137(237)97(43-46-119(163)221)187-155(255)125(76(5)6)204-148(248)103(54-81-24-14-12-15-25-81)192-145(245)108(63-122(224)225)195-136(236)96(42-45-118(162)220)181-131(231)77(7)179-133(233)93(31-22-49-174-159(168)169)182-134(234)94(32-23-50-175-160(170)171)184-152(252)112(70-211)201-147(247)110(65-124(228)229)196-140(240)100(53-75(3)4)188-141(241)101(56-83-33-37-88(217)38-34-83)190-135(235)92(30-20-21-48-173-158(166)167)183-151(251)111(69-210)199-142(242)102(57-84-35-39-89(218)40-36-84)191-146(246)109(64-123(226)227)197-154(254)114(72-213)202-157(257)128(80(10)216)206-149(249)104(55-82-26-16-13-17-27-82)198-156(256)127(79(9)215)203-121(223)68-177-132(232)95(41-44-117(161)219)185-153(253)113(71-212)200-144(244)106(59-86-67-172-73-178-86)180-129-115(208(260)261)60-87(207(258)259)61-116(129)209(262)263/h12-19,24-29,33-40,60-61,66-67,73-80,92-114,125-128,176,180,210-218H,20-23,30-32,41-59,62-65,68-72H2,1-11H3,(H2,161,219)(H2,162,220)(H2,163,221)(H2,164,222)(H2,165,230)(H,172,178)(H,177,232)(H,179,233)(H,181,231)(H,182,234)(H,183,251)(H,184,252)(H,185,253)(H,186,239)(H,187,255)(H,188,241)(H,189,243)(H,190,235)(H,191,246)(H,192,245)(H,193,237)(H,194,238)(H,195,236)(H,196,240)(H,197,254)(H,198,256)(H,199,242)(H,200,244)(H,201,247)(H,202,257)(H,203,223)(H,204,248)(H,205,250)(H,206,249)(H,224,225)(H,226,227)(H,228,229)(H4,166,167,173)(H4,168,169,174)(H4,170,171,175)/t77-,78+,79+,80+,92+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,125-,126-,127-,128-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 15n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon (inactive up to 100 microM)


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098566
PNG
(CHEMBL413208 | phenylbutyryl-Tyr-Ser-Lys-Tyr-Leu-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C123H180N32O33S/c1-63(2)51-83(110(177)142-82(46-50-189-9)109(176)149-89(57-96(127)163)118(185)155-101(67(8)158)102(128)169)145-114(181)88(56-72-60-135-76-29-17-16-28-75(72)76)148-108(175)81(43-45-95(126)162)143-121(188)100(65(5)6)154-117(184)87(53-69-25-14-11-15-26-69)147-115(182)90(58-98(165)166)150-107(174)80(42-44-94(125)161)138-103(170)66(7)136-104(171)78(31-21-48-133-122(129)130)139-105(172)79(32-22-49-134-123(131)132)141-120(187)93(62-157)153-116(183)91(59-99(167)168)151-111(178)84(52-64(3)4)144-113(180)86(55-71-36-40-74(160)41-37-71)146-106(173)77(30-18-19-47-124)140-119(186)92(61-156)152-112(179)85(54-70-34-38-73(159)39-35-70)137-97(164)33-20-27-68-23-12-10-13-24-68/h10-17,23-26,28-29,34-41,60,63-67,77-93,100-101,135,156-160H,18-22,27,30-33,42-59,61-62,124H2,1-9H3,(H2,125,161)(H2,126,162)(H2,127,163)(H2,128,169)(H,136,171)(H,137,164)(H,138,170)(H,139,172)(H,140,186)(H,141,187)(H,142,177)(H,143,188)(H,144,180)(H,145,181)(H,146,173)(H,147,182)(H,148,175)(H,149,176)(H,150,174)(H,151,178)(H,152,179)(H,153,183)(H,154,184)(H,155,185)(H,165,166)(H,167,168)(H4,129,130,133)(H4,131,132,134)/t66-,67+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,100-,101-/m0/s1
PDB

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UniProtKB/SwissProt

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PubMed
n/an/a 21.2n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098572
PNG
(Ac-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C135H198N36O41S/c1-65(2)50-87(118(197)154-86(45-49-213-11)117(196)162-94(57-103(139)182)128(207)170-108(69(8)175)110(140)189)157-122(201)93(56-76-61-147-80-29-19-18-28-79(76)80)161-116(195)85(42-44-102(138)181)155-132(211)107(67(5)6)169-127(206)92(53-73-26-16-13-17-27-73)160-123(202)95(58-104(183)184)163-115(194)84(41-43-101(137)180)150-111(190)68(7)148-112(191)82(31-22-47-145-134(141)142)151-113(192)83(32-23-48-146-135(143)144)153-130(209)99(63-173)167-125(204)97(60-106(187)188)164-119(198)88(51-66(3)4)156-120(199)90(54-74-33-37-77(178)38-34-74)158-114(193)81(30-20-21-46-136)152-129(208)98(62-172)166-121(200)91(55-75-35-39-78(179)40-36-75)159-124(203)96(59-105(185)186)165-131(210)100(64-174)168-133(212)109(70(9)176)171-126(205)89(149-71(10)177)52-72-24-14-12-15-25-72/h12-19,24-29,33-40,61,65-70,81-100,107-109,147,172-176,178-179H,20-23,30-32,41-60,62-64,136H2,1-11H3,(H2,137,180)(H2,138,181)(H2,139,182)(H2,140,189)(H,148,191)(H,149,177)(H,150,190)(H,151,192)(H,152,208)(H,153,209)(H,154,197)(H,155,211)(H,156,199)(H,157,201)(H,158,193)(H,159,203)(H,160,202)(H,161,195)(H,162,196)(H,163,194)(H,164,198)(H,165,210)(H,166,200)(H,167,204)(H,168,212)(H,169,206)(H,170,207)(H,171,205)(H,183,184)(H,185,186)(H,187,188)(H4,141,142,145)(H4,143,144,146)/t68-,69+,70+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-/m0/s1
PDB

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UniProtKB/SwissProt

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PubMed
n/an/a 31n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098570
PNG
(CHEMBL438045 | Ser-Gln-Gly-Thr-Thr-Ser-Glu-Tyr-Ser...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C139H212N40O46S/c1-64(2)49-88(123(211)162-87(44-48-226-11)122(210)170-94(55-103(145)192)131(219)178-109(68(8)184)112(146)200)165-127(215)93(54-74-58-153-79-24-16-15-23-77(74)79)169-120(208)85(38-42-102(144)191)163-135(223)108(66(5)6)177-130(218)92(51-71-21-13-12-14-22-71)168-128(216)95(56-106(196)197)171-119(207)84(37-41-101(143)190)156-113(201)67(7)155-116(204)81(26-19-46-151-138(147)148)158-117(205)82(27-20-47-152-139(149)150)160-133(221)98(62-182)174-129(217)96(57-107(198)199)172-124(212)89(50-65(3)4)164-125(213)90(52-72-28-32-75(187)33-29-72)166-118(206)80(25-17-18-45-140)159-132(220)97(61-181)173-126(214)91(53-73-30-34-76(188)35-31-73)167-121(209)86(39-43-105(194)195)161-134(222)99(63-183)175-136(224)111(70(10)186)179-137(225)110(69(9)185)176-104(193)59-154-115(203)83(36-40-100(142)189)157-114(202)78(141)60-180/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,153,180-188H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,192)(H2,146,200)(H,154,203)(H,155,204)(H,156,201)(H,157,202)(H,158,205)(H,159,220)(H,160,221)(H,161,222)(H,162,211)(H,163,223)(H,164,213)(H,165,215)(H,166,206)(H,167,209)(H,168,216)(H,169,208)(H,170,210)(H,171,207)(H,172,212)(H,173,214)(H,174,217)(H,175,224)(H,176,193)(H,177,218)(H,178,219)(H,179,225)(H,194,195)(H,196,197)(H,198,199)(H4,147,148,151)(H4,149,150,152)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m0/s1
PDB

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Article
PubMed
n/an/a 48n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Compound was evaluated for its ability to displace radiolabelled glucagon


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098565
PNG
(Ac-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C115H172N32O33S/c1-56(2)44-76(102(169)134-75(39-43-181-10)101(168)141-82(50-89(119)156)110(177)147-93(60(8)150)94(120)161)137-106(173)81(49-65-53-127-69-23-15-14-22-68(65)69)140-100(167)74(36-38-88(118)155)135-113(180)92(58(5)6)146-109(176)80(46-62-20-12-11-13-21-62)139-107(174)83(51-90(157)158)142-99(166)73(35-37-87(117)154)130-95(162)59(7)128-96(163)71(25-18-41-125-114(121)122)131-97(164)72(26-19-42-126-115(123)124)133-112(179)86(55-149)145-108(175)84(52-91(159)160)143-103(170)77(45-57(3)4)136-105(172)79(48-64-29-33-67(153)34-30-64)138-98(165)70(24-16-17-40-116)132-111(178)85(54-148)144-104(171)78(129-61(9)151)47-63-27-31-66(152)32-28-63/h11-15,20-23,27-34,53,56-60,70-86,92-93,127,148-150,152-153H,16-19,24-26,35-52,54-55,116H2,1-10H3,(H2,117,154)(H2,118,155)(H2,119,156)(H2,120,161)(H,128,163)(H,129,151)(H,130,162)(H,131,164)(H,132,178)(H,133,179)(H,134,169)(H,135,180)(H,136,172)(H,137,173)(H,138,165)(H,139,174)(H,140,167)(H,141,168)(H,142,166)(H,143,170)(H,144,171)(H,145,175)(H,146,176)(H,147,177)(H,157,158)(H,159,160)(H4,121,122,125)(H4,123,124,126)/t59-,60+,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,92-,93-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098567
PNG
(CHEMBL439690 | phenylhexanoyl-Tyr-Ser-Lys-Tyr-Leu-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C125H184N32O33S/c1-65(2)53-85(112(179)144-84(48-52-191-9)111(178)151-91(59-98(129)165)120(187)157-103(69(8)160)104(130)171)147-116(183)90(58-74-62-137-78-31-20-19-30-77(74)78)150-110(177)83(45-47-97(128)164)145-123(190)102(67(5)6)156-119(186)89(55-71-28-16-11-17-29-71)149-117(184)92(60-100(167)168)152-109(176)82(44-46-96(127)163)140-105(172)68(7)138-106(173)80(33-23-50-135-124(131)132)141-107(174)81(34-24-51-136-125(133)134)143-122(189)95(64-159)155-118(185)93(61-101(169)170)153-113(180)86(54-66(3)4)146-115(182)88(57-73-38-42-76(162)43-39-73)148-108(175)79(32-21-22-49-126)142-121(188)94(63-158)154-114(181)87(56-72-36-40-75(161)41-37-72)139-99(166)35-18-12-15-27-70-25-13-10-14-26-70/h10-11,13-14,16-17,19-20,25-26,28-31,36-43,62,65-69,79-95,102-103,137,158-162H,12,15,18,21-24,27,32-35,44-61,63-64,126H2,1-9H3,(H2,127,163)(H2,128,164)(H2,129,165)(H2,130,171)(H,138,173)(H,139,166)(H,140,172)(H,141,174)(H,142,188)(H,143,189)(H,144,179)(H,145,190)(H,146,182)(H,147,183)(H,148,175)(H,149,184)(H,150,177)(H,151,178)(H,152,176)(H,153,180)(H,154,181)(H,155,185)(H,156,186)(H,157,187)(H,167,168)(H,169,170)(H4,131,132,135)(H4,133,134,136)/t68-,69+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,102-,103-/m0/s1
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n/an/a 131n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098564
PNG
(CHEMBL262418 | Phenacetyl-Tyr-Ser-Lys-Tyr-Leu-Asp-...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C121H176N32O33S/c1-61(2)48-81(108(175)140-80(43-47-187-9)107(174)147-87(55-94(125)161)116(183)153-99(65(8)156)100(126)167)143-112(179)86(54-70-58-133-74-27-17-16-26-73(70)74)146-106(173)79(40-42-93(124)160)141-119(186)98(63(5)6)152-115(182)85(50-66-22-12-10-13-23-66)145-113(180)88(56-96(163)164)148-105(172)78(39-41-92(123)159)136-101(168)64(7)134-102(169)76(29-20-45-131-120(127)128)137-103(170)77(30-21-46-132-121(129)130)139-118(185)91(60-155)151-114(181)89(57-97(165)166)149-109(176)82(49-62(3)4)142-111(178)84(52-69-33-37-72(158)38-34-69)144-104(171)75(28-18-19-44-122)138-117(184)90(59-154)150-110(177)83(51-68-31-35-71(157)36-32-68)135-95(162)53-67-24-14-11-15-25-67/h10-17,22-27,31-38,58,61-65,75-91,98-99,133,154-158H,18-21,28-30,39-57,59-60,122H2,1-9H3,(H2,123,159)(H2,124,160)(H2,125,161)(H2,126,167)(H,134,169)(H,135,162)(H,136,168)(H,137,170)(H,138,184)(H,139,185)(H,140,175)(H,141,186)(H,142,178)(H,143,179)(H,144,171)(H,145,180)(H,146,173)(H,147,174)(H,148,172)(H,149,176)(H,150,177)(H,151,181)(H,152,182)(H,153,183)(H,163,164)(H,165,166)(H4,127,128,131)(H4,129,130,132)/t64-,65+,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,98-,99-/m0/s1
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n/an/a 249n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098574
PNG
(CHEMBL409896 | phenylbutyryl-Tyr-Ser-Lys-2-Nal-Leu...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCc1ccccc1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C127H182N32O32S/c1-66(2)53-87(114(180)146-86(48-52-192-9)113(179)153-93(60-100(131)166)122(188)159-105(70(8)162)106(132)172)149-118(184)92(59-77-63-139-80-33-19-18-32-79(77)80)152-112(178)85(45-47-99(130)165)147-125(191)104(68(5)6)158-121(187)90(56-72-27-14-11-15-28-72)151-119(185)94(61-102(168)169)154-111(177)84(44-46-98(129)164)142-107(173)69(7)140-108(174)82(35-23-50-137-126(133)134)143-109(175)83(36-24-51-138-127(135)136)145-124(190)97(65-161)157-120(186)95(62-103(170)171)155-115(181)88(54-67(3)4)148-117(183)91(58-74-38-41-75-30-16-17-31-76(75)55-74)150-110(176)81(34-20-21-49-128)144-123(189)96(64-160)156-116(182)89(57-73-39-42-78(163)43-40-73)141-101(167)37-22-29-71-25-12-10-13-26-71/h10-19,25-28,30-33,38-43,55,63,66-70,81-97,104-105,139,160-163H,20-24,29,34-37,44-54,56-62,64-65,128H2,1-9H3,(H2,129,164)(H2,130,165)(H2,131,166)(H2,132,172)(H,140,174)(H,141,167)(H,142,173)(H,143,175)(H,144,189)(H,145,190)(H,146,180)(H,147,191)(H,148,183)(H,149,184)(H,150,176)(H,151,185)(H,152,178)(H,153,179)(H,154,177)(H,155,181)(H,156,182)(H,157,186)(H,158,187)(H,159,188)(H,168,169)(H,170,171)(H4,133,134,137)(H4,135,136,138)/t69-,70+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,104-,105-/m0/s1
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n/an/a 781n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed for inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098569
PNG
(Ac-Nal-Ser-Lys-Nal-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C123H176N32O31S/c1-62(2)48-84(110(175)142-83(43-47-187-10)109(174)149-90(56-97(127)162)118(183)155-101(66(8)158)102(128)167)145-114(179)89(55-75-59-135-77-31-19-18-30-76(75)77)148-108(173)82(40-42-96(126)161)143-121(186)100(64(5)6)154-117(182)87(52-68-24-12-11-13-25-68)147-115(180)91(57-98(163)164)150-107(172)81(39-41-95(125)160)138-103(168)65(7)136-104(169)79(33-22-45-133-122(129)130)139-105(170)80(34-23-46-134-123(131)132)141-120(185)94(61-157)153-116(181)92(58-99(165)166)151-111(176)85(49-63(3)4)144-113(178)88(54-70-36-38-72-27-15-17-29-74(72)51-70)146-106(171)78(32-20-21-44-124)140-119(184)93(60-156)152-112(177)86(137-67(9)159)53-69-35-37-71-26-14-16-28-73(71)50-69/h11-19,24-31,35-38,50-51,59,62-66,78-94,100-101,135,156-158H,20-23,32-34,39-49,52-58,60-61,124H2,1-10H3,(H2,125,160)(H2,126,161)(H2,127,162)(H2,128,167)(H,136,169)(H,137,159)(H,138,168)(H,139,170)(H,140,184)(H,141,185)(H,142,175)(H,143,186)(H,144,178)(H,145,179)(H,146,171)(H,147,180)(H,148,173)(H,149,174)(H,150,172)(H,151,176)(H,152,177)(H,153,181)(H,154,182)(H,155,183)(H,163,164)(H,165,166)(H4,129,130,133)(H4,131,132,134)/t65-,66+,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
Glucagon receptor


(Rattus norvegicus)
BDBM50098568
PNG
(Ac-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C75H116N24O20S/c1-36(2)30-50(68(114)91-49(26-29-120-8)67(113)96-53(33-57(78)104)72(118)99-60(39(6)100)61(79)107)93-69(115)52(32-42-35-86-44-19-13-12-18-43(42)44)95-66(112)48(23-25-56(77)103)92-73(119)59(37(3)4)98-71(117)51(31-41-16-10-9-11-17-41)94-70(116)54(34-58(105)106)97-65(111)47(22-24-55(76)102)89-62(108)38(5)87-63(109)46(21-15-28-85-75(82)83)90-64(110)45(88-40(7)101)20-14-27-84-74(80)81/h9-13,16-19,35-39,45-54,59-60,86,100H,14-15,20-34H2,1-8H3,(H2,76,102)(H2,77,103)(H2,78,104)(H2,79,107)(H,87,109)(H,88,101)(H,89,108)(H,90,110)(H,91,114)(H,92,119)(H,93,115)(H,94,116)(H,95,112)(H,96,113)(H,97,111)(H,98,117)(H,99,118)(H,105,106)(H4,80,81,84)(H4,82,83,85)/t38-,39+,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-,60-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
IC50 value of the compound was expressed as inhibition of [125]glucagon specific binding.


J Med Chem 44: 1372-9 (2001)


Article DOI: 10.1021/jm000453e
BindingDB Entry DOI: 10.7270/Q2VH5N3N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%