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PubMed code 11392531

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100300
PNG
(2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...)
Show SMILES Clc1ccc(Sc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2N3S/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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PubMed
n/an/a<1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100278
PNG
(2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...)
Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC
Show InChI InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100286
PNG
(4-Imidazol-1-ylmethyl-2-(naphthalen-2-yloxy)-benzo...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccc2ccccc2c1
Show InChI InChI=1S/C21H15N3O/c22-13-19-6-5-16(14-24-10-9-23-15-24)11-21(19)25-20-8-7-17-3-1-2-4-18(17)12-20/h1-12,15H,14H2
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n/an/a 1.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100279
PNG
(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Show SMILES CCC1(CCCCN(C)C1=O)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C26H28N4O2/c1-3-26(11-4-5-13-29(2)25(26)31)22-7-6-8-23(16-22)32-24-15-20(9-10-21(24)17-27)18-30-14-12-28-19-30/h6-10,12,14-16,19H,3-5,11,13,18H2,1-2H3
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n/an/a 2.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50100279
PNG
(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Show SMILES CCC1(CCCCN(C)C1=O)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C26H28N4O2/c1-3-26(11-4-5-13-29(2)25(26)31)22-7-6-8-23(16-22)32-24-15-20(9-10-21(24)17-27)18-30-14-12-28-19-30/h6-10,12,14-16,19H,3-5,11,13,18H2,1-2H3
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n/an/a 4.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100279
PNG
(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Show SMILES CCC1(CCCCN(C)C1=O)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C26H28N4O2/c1-3-26(11-4-5-13-29(2)25(26)31)22-7-6-8-23(16-22)32-24-15-20(9-10-21(24)17-27)18-30-14-12-28-19-30/h6-10,12,14-16,19H,3-5,11,13,18H2,1-2H3
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n/an/a 7.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100305
PNG
(2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2N3O/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100296
PNG
(2-(Biphenyl-3-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c24-15-21-10-9-18(16-26-12-11-25-17-26)13-23(21)27-22-8-4-7-20(14-22)19-5-2-1-3-6-19/h1-14,17H,16H2
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n/an/a 9.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100292
PNG
(2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzon...)
Show SMILES O=C(c1ccccc1)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C24H17N3O2/c25-15-21-10-9-18(16-27-12-11-26-17-27)13-23(21)29-22-8-4-7-20(14-22)24(28)19-5-2-1-3-6-19/h1-14,17H,16H2
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n/an/a 13n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100303
PNG
(4-Imidazol-1-ylmethyl-2-(3-phenoxy-phenoxy)-benzon...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H17N3O2/c24-15-19-10-9-18(16-26-12-11-25-17-26)13-23(19)28-22-8-4-7-21(14-22)27-20-5-2-1-3-6-20/h1-14,17H,16H2
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50100278
PNG
(2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...)
Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC
Show InChI InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3
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n/an/a 14n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100308
PNG
(4-Imidazol-1-ylmethyl-2-(3-phenylamino-phenoxy)-be...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(Nc2ccccc2)c1
Show InChI InChI=1S/C23H18N4O/c24-15-19-10-9-18(16-27-12-11-25-17-27)13-23(19)28-22-8-4-7-21(14-22)26-20-5-2-1-3-6-20/h1-14,17,26H,16H2
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100300
PNG
(2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...)
Show SMILES Clc1ccc(Sc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2N3S/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 23n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100309
PNG
(2-(3-tert-Butyl-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES CC(C)(C)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C21H21N3O/c1-21(2,3)18-5-4-6-19(12-18)25-20-11-16(7-8-17(20)13-22)14-24-10-9-23-15-24/h4-12,15H,14H2,1-3H3
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n/an/a 27n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100283
PNG
(2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzon...)
Show SMILES C#Cc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C19H13N3O/c1-2-15-4-3-5-18(10-15)23-19-11-16(6-7-17(19)12-20)13-22-9-8-21-14-22/h1,3-11,14H,13H2
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n/an/a 27n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100311
PNG
(2-(3,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1Cl
Show InChI InChI=1S/C17H11Cl2N3O/c18-15-4-3-14(8-16(15)19)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 28n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100299
PNG
(CHEMBL423109 | N-[3-(2-Cyano-5-imidazol-1-ylmethyl...)
Show SMILES O=C(Nc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1)c1ccccc1
Show InChI InChI=1S/C24H18N4O2/c25-15-20-10-9-18(16-28-12-11-26-17-28)13-23(20)30-22-8-4-7-21(14-22)27-24(29)19-5-2-1-3-6-19/h1-14,17H,16H2,(H,27,29)
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n/an/a 38n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100304
PNG
(2-(4-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1
Show InChI InChI=1S/C17H12ClN3O/c18-15-3-5-16(6-4-15)22-17-9-13(1-2-14(17)10-19)11-21-8-7-20-12-21/h1-9,12H,11H2
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n/an/a 38n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100298
PNG
(2-(3-Bromo-phenoxy)-4-imidazol-1-ylmethyl-benzonit...)
Show SMILES Brc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C17H12BrN3O/c18-15-2-1-3-16(9-15)22-17-8-13(4-5-14(17)10-19)11-21-7-6-20-12-21/h1-9,12H,11H2
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n/an/a 38n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100290
PNG
(3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl...)
Show SMILES O=C(Nc1ccccc1)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C24H18N4O2/c25-15-20-10-9-18(16-28-12-11-26-17-28)13-23(20)30-22-8-4-5-19(14-22)24(29)27-21-6-2-1-3-7-21/h1-14,17H,16H2,(H,27,29)
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n/an/a 38n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100289
PNG
(4-Imidazol-1-ylmethyl-2-(3-methoxy-phenoxy)-benzon...)
Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C18H15N3O2/c1-22-16-3-2-4-17(10-16)23-18-9-14(5-6-15(18)11-19)12-21-8-7-20-13-21/h2-10,13H,12H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100294
PNG
(2-(2-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Clc1ccccc1Oc1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C17H12ClN3O/c18-15-3-1-2-4-16(15)22-17-9-13(5-6-14(17)10-19)11-21-8-7-20-12-21/h1-9,12H,11H2
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n/an/a 41n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100287
PNG
(2-(3-Acetyl-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES CC(=O)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C19H15N3O2/c1-14(23)16-3-2-4-18(10-16)24-19-9-15(5-6-17(19)11-20)12-22-8-7-21-13-22/h2-10,13H,12H2,1H3
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n/an/a 45n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100302
PNG
(2-(3-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Clc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C17H12ClN3O/c18-15-2-1-3-16(9-15)22-17-8-13(4-5-14(17)10-19)11-21-7-6-20-12-21/h1-9,12H,11H2
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n/an/a 53n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100307
PNG
(2-(2-Biphenyl-4-yl-ethoxy)-4-imidazol-1-ylmethyl-b...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H21N3O/c26-17-24-11-8-21(18-28-14-13-27-19-28)16-25(24)29-15-12-20-6-9-23(10-7-20)22-4-2-1-3-5-22/h1-11,13-14,16,19H,12,15,18H2
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n/an/a 86n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50100300
PNG
(2-(2,4-Dichloro-phenylsulfanyl)-4-imidazol-1-ylmet...)
Show SMILES Clc1ccc(Sc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2N3S/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 96n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100276
PNG
(2-(2,5-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...)
Show SMILES COc1ccc(OC)c(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C19H17N3O3/c1-23-16-5-6-17(24-2)19(10-16)25-18-9-14(3-4-15(18)11-20)12-22-8-7-21-13-22/h3-10,13H,12H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100293
PNG
(2-(Biphenyl-2-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c24-15-20-11-10-18(16-26-13-12-25-17-26)14-23(20)27-22-9-5-4-8-21(22)19-6-2-1-3-7-19/h1-14,17H,16H2
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n/an/a 110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100291
PNG
(2-(3-Cyano-phenoxy)-4-imidazol-1-ylmethyl-benzonit...)
Show SMILES N#Cc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C18H12N4O/c19-10-14-2-1-3-17(8-14)23-18-9-15(4-5-16(18)11-20)12-22-7-6-21-13-22/h1-9,13H,12H2
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100310
PNG
(4-Imidazol-1-ylmethyl-2-(naphthalen-1-yloxy)-benzo...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc2ccccc12
Show InChI InChI=1S/C21H15N3O/c22-13-18-9-8-16(14-24-11-10-23-15-24)12-21(18)25-20-7-3-5-17-4-1-2-6-19(17)20/h1-12,15H,14H2
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n/an/a 150n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100306
PNG
(2-(3-Fluoro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Fc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C17H12FN3O/c18-15-2-1-3-16(9-15)22-17-8-13(4-5-14(17)10-19)11-21-7-6-20-12-21/h1-9,12H,11H2
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n/an/a 180n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100282
PNG
(4-Imidazol-1-ylmethyl-2-(3-phenyl-propoxy)-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCCc1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-19-9-8-18(15-23-11-10-22-16-23)13-20(19)24-12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,13,16H,4,7,12,15H2
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n/an/a 200n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100277
PNG
(2-(3-Benzyl-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C24H19N3O/c25-16-22-10-9-21(17-27-12-11-26-18-27)15-24(22)28-23-8-4-7-20(14-23)13-19-5-2-1-3-6-19/h1-12,14-15,18H,13,17H2
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100281
PNG
(4-Imidazol-1-ylmethyl-2-phenoxy-benzonitrile | CHE...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccccc1
Show InChI InChI=1S/C17H13N3O/c18-11-15-7-6-14(12-20-9-8-19-13-20)10-17(15)21-16-4-2-1-3-5-16/h1-10,13H,12H2
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit


(Rattus norvegicus-Rattus norvegicus (rat))
BDBM50100305
PNG
(2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2N3O/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 260n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in cultured v-Ha-ras-transformed RAT1 cells


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100303
PNG
(4-Imidazol-1-ylmethyl-2-(3-phenoxy-phenoxy)-benzon...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H17N3O2/c24-15-19-10-9-18(16-26-12-11-25-17-26)13-23(19)28-22-8-4-7-21(14-22)27-20-5-2-1-3-6-20/h1-14,17H,16H2
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n/an/a 280n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100305
PNG
(2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2N3O/c18-14-3-4-16(15(19)8-14)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 280n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100295
PNG
(4-Imidazol-1-ylmethyl-2-(4-methoxy-phenoxy)-benzon...)
Show SMILES COc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1
Show InChI InChI=1S/C18H15N3O2/c1-22-16-4-6-17(7-5-16)23-18-10-14(2-3-15(18)11-19)12-21-9-8-20-13-21/h2-10,13H,12H2,1H3
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n/an/a 290n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100312
PNG
(4-Imidazol-1-ylmethyl-2-(2-methoxy-phenoxy)-benzon...)
Show SMILES COc1ccccc1Oc1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C18H15N3O2/c1-22-16-4-2-3-5-17(16)23-18-10-14(6-7-15(18)11-19)12-21-9-8-20-13-21/h2-10,13H,12H2,1H3
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n/an/a 340n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100297
PNG
(4-Imidazol-1-ylmethyl-2-(4-phenyl-butoxy)-benzonit...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCCCc1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-15-20-10-9-19(16-24-12-11-23-17-24)14-21(20)25-13-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-12,14,17H,4-5,8,13,16H2
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n/an/a 380n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100313
PNG
(2-(2,4-Dichloro-benzenesulfinyl)-4-imidazol-1-ylme...)
Show SMILES Clc1ccc(c(Cl)c1)S(=O)c1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C17H11Cl2N3OS/c18-14-3-4-16(15(19)8-14)24(23)17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 390n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100297
PNG
(4-Imidazol-1-ylmethyl-2-(4-phenyl-butoxy)-benzonit...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCCCc1ccccc1
Show InChI InChI=1S/C21H21N3O/c22-15-20-10-9-19(16-24-12-11-23-17-24)14-21(20)25-13-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-12,14,17H,4-5,8,13,16H2
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n/an/a 440n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100285
PNG
(4-{5-[4-(3-Chloro-phenyl)-2-(2-methanesulfonyl-eth...)
Show SMILES Cc1ncn(Cc2ccc(cc2)C#N)c1CN1CC(=O)N(CC1CCS(C)(=O)=O)c1cccc(Cl)c1
Show InChI InChI=1S/C26H28ClN5O3S/c1-19-25(31(18-29-19)14-21-8-6-20(13-28)7-9-21)16-30-17-26(33)32(23-5-3-4-22(27)12-23)15-24(30)10-11-36(2,34)35/h3-9,12,18,24H,10-11,14-17H2,1-2H3
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n/an/a 475n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100286
PNG
(4-Imidazol-1-ylmethyl-2-(naphthalen-2-yloxy)-benzo...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccc2ccccc2c1
Show InChI InChI=1S/C21H15N3O/c22-13-19-6-5-16(14-24-10-9-23-15-24)11-21(19)25-20-8-7-17-3-1-2-4-18(17)12-20/h1-12,15H,14H2
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n/an/a 520n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100309
PNG
(2-(3-tert-Butyl-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES CC(C)(C)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C21H21N3O/c1-21(2,3)18-5-4-6-19(12-18)25-20-11-16(7-8-17(20)13-22)14-24-10-9-23-15-24/h4-12,15H,14H2,1-3H3
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n/an/a 520n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100296
PNG
(2-(Biphenyl-3-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c24-15-21-10-9-18(16-26-12-11-25-17-26)13-23(21)27-22-8-4-7-20(14-22)19-5-2-1-3-6-19/h1-14,17H,16H2
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n/an/a 520n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100277
PNG
(2-(3-Benzyl-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C24H19N3O/c25-16-22-10-9-21(17-27-12-11-26-18-27)15-24(22)28-23-8-4-7-20(14-23)13-19-5-2-1-3-6-19/h1-12,14-15,18H,13,17H2
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n/an/a 600n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in cultured v-Ha-ras-transformed RAT1 cells


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100308
PNG
(4-Imidazol-1-ylmethyl-2-(3-phenylamino-phenoxy)-be...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc(Nc2ccccc2)c1
Show InChI InChI=1S/C23H18N4O/c24-15-19-10-9-18(16-27-12-11-25-17-27)13-23(19)28-22-8-4-7-21(14-22)26-20-5-2-1-3-6-20/h1-14,17,26H,16H2
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n/an/a 630n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100293
PNG
(2-(Biphenyl-2-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c24-15-20-11-10-18(16-26-13-12-25-17-26)14-23(20)27-22-9-5-4-8-21(22)19-6-2-1-3-7-19/h1-14,17H,16H2
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n/an/a 740n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100292
PNG
(2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzon...)
Show SMILES O=C(c1ccccc1)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C24H17N3O2/c25-15-21-10-9-18(16-27-12-11-26-17-27)13-23(21)29-22-8-4-7-20(14-22)24(28)19-5-2-1-3-6-19/h1-14,17H,16H2
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n/an/a 840n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100280
PNG
(4-Imidazol-1-ylmethyl-2-phenethyloxy-benzonitrile ...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCc1ccccc1
Show InChI InChI=1S/C19H17N3O/c20-13-18-7-6-17(14-22-10-9-21-15-22)12-19(18)23-11-8-16-4-2-1-3-5-16/h1-7,9-10,12,15H,8,11,14H2
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n/an/a 860n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100304
PNG
(2-(4-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1
Show InChI InChI=1S/C17H12ClN3O/c18-15-3-5-16(6-4-15)22-17-9-13(1-2-14(17)10-19)11-21-8-7-20-12-21/h1-9,12H,11H2
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n/an/a 920n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100294
PNG
(2-(2-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Clc1ccccc1Oc1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C17H12ClN3O/c18-15-3-1-2-4-16(15)22-17-9-13(5-6-14(17)10-19)11-21-8-7-20-12-21/h1-9,12H,11H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100311
PNG
(2-(3,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1Cl
Show InChI InChI=1S/C17H11Cl2N3O/c18-15-4-3-14(8-16(15)19)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100288
PNG
(2-(Biphenyl-4-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c24-15-21-7-6-18(16-26-13-12-25-17-26)14-23(21)27-22-10-8-20(9-11-22)19-4-2-1-3-5-19/h1-14,17H,16H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100301
PNG
(2-Benzyloxy-4-imidazol-1-ylmethyl-benzonitrile | C...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-11-17-7-6-16(12-21-9-8-20-14-21)10-18(17)22-13-15-4-2-1-3-5-15/h1-10,14H,12-13H2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100299
PNG
(CHEMBL423109 | N-[3-(2-Cyano-5-imidazol-1-ylmethyl...)
Show SMILES O=C(Nc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1)c1ccccc1
Show InChI InChI=1S/C24H18N4O2/c25-15-20-10-9-18(16-28-12-11-26-17-28)13-23(20)30-22-8-4-7-21(14-22)27-24(29)19-5-2-1-3-6-19/h1-14,17H,16H2,(H,27,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100313
PNG
(2-(2,4-Dichloro-benzenesulfinyl)-4-imidazol-1-ylme...)
Show SMILES Clc1ccc(c(Cl)c1)S(=O)c1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C17H11Cl2N3OS/c18-14-3-4-16(15(19)8-14)24(23)17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in cultured v-Ha-ras-transformed RAT1 cells


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100283
PNG
(2-(3-Ethynyl-phenoxy)-4-imidazol-1-ylmethyl-benzon...)
Show SMILES C#Cc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C19H13N3O/c1-2-15-4-3-5-18(10-15)23-19-11-16(6-7-17(19)12-20)13-22-9-8-21-14-22/h1,3-11,14H,13H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100298
PNG
(2-(3-Bromo-phenoxy)-4-imidazol-1-ylmethyl-benzonit...)
Show SMILES Brc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C17H12BrN3O/c18-15-2-1-3-16(9-15)22-17-8-13(4-5-14(17)10-19)11-21-7-6-20-12-21/h1-9,12H,11H2
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n/an/a 2.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100282
PNG
(4-Imidazol-1-ylmethyl-2-(3-phenyl-propoxy)-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCCc1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-19-9-8-18(15-23-11-10-22-16-23)13-20(19)24-12-4-7-17-5-2-1-3-6-17/h1-3,5-6,8-11,13,16H,4,7,12,15H2
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n/an/a 3.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100302
PNG
(2-(3-Chloro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Clc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C17H12ClN3O/c18-15-2-1-3-16(9-15)22-17-8-13(4-5-14(17)10-19)11-21-7-6-20-12-21/h1-9,12H,11H2
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n/an/a 3.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100310
PNG
(4-Imidazol-1-ylmethyl-2-(naphthalen-1-yloxy)-benzo...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1cccc2ccccc12
Show InChI InChI=1S/C21H15N3O/c22-13-18-9-8-16(14-24-11-10-23-15-24)12-21(18)25-20-7-3-5-17-4-1-2-6-19(17)20/h1-12,15H,14H2
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n/an/a 3.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100290
PNG
(3-(2-Cyano-5-imidazol-1-ylmethyl-phenoxy)-N-phenyl...)
Show SMILES O=C(Nc1ccccc1)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C24H18N4O2/c25-15-20-10-9-18(16-28-12-11-26-17-28)13-23(20)30-22-8-4-5-19(14-22)24(29)27-21-6-2-1-3-7-21/h1-14,17H,16H2,(H,27,29)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100288
PNG
(2-(Biphenyl-4-yloxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H17N3O/c24-15-21-7-6-18(16-26-13-12-25-17-26)14-23(21)27-22-10-8-20(9-11-22)19-4-2-1-3-5-19/h1-14,17H,16H2
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n/an/a 3.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100289
PNG
(4-Imidazol-1-ylmethyl-2-(3-methoxy-phenoxy)-benzon...)
Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C18H15N3O2/c1-22-16-3-2-4-17(10-16)23-18-9-14(5-6-15(18)11-19)12-21-8-7-20-13-21/h2-10,13H,12H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-trans...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100295
PNG
(4-Imidazol-1-ylmethyl-2-(4-methoxy-phenoxy)-benzon...)
Show SMILES COc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1
Show InChI InChI=1S/C18H15N3O2/c1-22-16-4-6-17(7-5-16)23-18-10-14(2-3-15(18)11-19)12-21-9-8-20-13-21/h2-10,13H,12H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100281
PNG
(4-Imidazol-1-ylmethyl-2-phenoxy-benzonitrile | CHE...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1Oc1ccccc1
Show InChI InChI=1S/C17H13N3O/c18-11-15-7-6-14(12-20-9-8-19-13-20)10-17(15)21-16-4-2-1-3-5-16/h1-10,13H,12H2
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n/an/a 3.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100306
PNG
(2-(3-Fluoro-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES Fc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C17H12FN3O/c18-15-2-1-3-16(9-15)22-17-8-13(4-5-14(17)10-19)11-21-7-6-20-12-21/h1-9,12H,11H2
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n/an/a 4.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100284
PNG
(2-(2,4-Dichloro-benzenesulfonyl)-4-imidazol-1-ylme...)
Show SMILES Clc1ccc(c(Cl)c1)S(=O)(=O)c1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C17H11Cl2N3O2S/c18-14-3-4-16(15(19)8-14)25(23,24)17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100287
PNG
(2-(3-Acetyl-phenoxy)-4-imidazol-1-ylmethyl-benzoni...)
Show SMILES CC(=O)c1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C19H15N3O2/c1-14(23)16-3-2-4-18(10-16)24-19-9-15(5-6-17(19)11-20)12-22-8-7-21-13-22/h2-10,13H,12H2,1H3
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n/an/a 6.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100301
PNG
(2-Benzyloxy-4-imidazol-1-ylmethyl-benzonitrile | C...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCc1ccccc1
Show InChI InChI=1S/C18H15N3O/c19-11-17-7-6-16(12-21-9-8-20-14-21)10-18(17)22-13-15-4-2-1-3-5-15/h1-10,14H,12-13H2
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n/an/a 6.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100280
PNG
(4-Imidazol-1-ylmethyl-2-phenethyloxy-benzonitrile ...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCc1ccccc1
Show InChI InChI=1S/C19H17N3O/c20-13-18-7-6-17(14-22-10-9-21-15-22)12-19(18)23-11-8-16-4-2-1-3-5-16/h1-7,9-10,12,15H,8,11,14H2
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n/an/a 7.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radiolabeled FTI from Farnesyltransferase in cultured v-Ha-ras-transformed RAT1 cells


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100284
PNG
(2-(2,4-Dichloro-benzenesulfonyl)-4-imidazol-1-ylme...)
Show SMILES Clc1ccc(c(Cl)c1)S(=O)(=O)c1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C17H11Cl2N3O2S/c18-14-3-4-16(15(19)8-14)25(23,24)17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
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n/an/a 8.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100307
PNG
(2-(2-Biphenyl-4-yl-ethoxy)-4-imidazol-1-ylmethyl-b...)
Show SMILES N#Cc1ccc(Cn2ccnc2)cc1OCCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H21N3O/c26-17-24-11-8-21(18-28-14-13-27-19-28)16-25(24)29-15-12-20-6-9-23(10-7-20)22-4-2-1-3-5-22/h1-11,13-14,16,19H,12,15,18H2
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n/an/a 1.20E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100278
PNG
(2-(2,3-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...)
Show SMILES COc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1OC
Show InChI InChI=1S/C19H17N3O3/c1-23-16-4-3-5-17(19(16)24-2)25-18-10-14(6-7-15(18)11-20)12-22-9-8-21-13-22/h3-10,13H,12H2,1-2H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100291
PNG
(2-(3-Cyano-phenoxy)-4-imidazol-1-ylmethyl-benzonit...)
Show SMILES N#Cc1cccc(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C18H12N4O/c19-10-14-2-1-3-17(8-14)23-18-9-15(4-5-16(18)11-20)12-22-7-6-21-13-22/h1-9,13H,12H2
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100276
PNG
(2-(2,5-Dimethoxy-phenoxy)-4-imidazol-1-ylmethyl-be...)
Show SMILES COc1ccc(OC)c(Oc2cc(Cn3ccnc3)ccc2C#N)c1
Show InChI InChI=1S/C19H17N3O3/c1-23-16-5-6-17(24-2)19(10-16)25-18-9-14(3-4-15(18)11-20)12-22-8-7-21-13-22/h3-10,13H,12H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

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UniChem

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PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50100312
PNG
(4-Imidazol-1-ylmethyl-2-(2-methoxy-phenoxy)-benzon...)
Show SMILES COc1ccccc1Oc1cc(Cn2ccnc2)ccc1C#N
Show InChI InChI=1S/C18H15N3O2/c1-22-16-4-2-3-5-17(16)23-18-10-14(6-7-15(18)11-19)12-21-9-8-20-13-21/h2-10,13H,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...


Bioorg Med Chem Lett 11: 1257-60 (2001)


Article DOI: 10.1016/s0960-894x(01)00162-7
BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%